NTS1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Rattus norvegicus

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

March 29, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

neurotensin - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig

PHYSIOLOGICAL LIGANDS

neurotensin, neuromedin N



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 P 174 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 235 G.H5.15
Hydrophobic TM2 L 106 2x43 G.H5 N 244 G.H5.24
Van-der-waals TM2 L 106 2x43 G.H5 N 244 G.H5.24
Hydrophobic TM3 I 171 3x54 G.H5 L 245 G.H5.25
Polar TM7 N 370 7x54 G.H5 N 244 G.H5.24
Hydrophobic ICL2 P 174 34x50 G.H5 K 232 G.H5.12
Hydrophobic TM2 V 102 2x39 G.H5 E 242 G.H5.22
Van-der-waals TM2 V 102 2x39 G.H5 E 242 G.H5.22
Hydrophobic TM3 R 167 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 167 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 175 34x51 G.S1 L 34 G.S1.02
Van-der-waals ICL2 F 175 34x51 G.S1 L 34 G.S1.02
Polar TM6 G 306 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 G 306 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 G 306 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM2 V 102 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 V 102 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM6 L 303 6x30 G.H5 L 240 G.H5.20
Van-der-waals TM6 L 303 6x30 G.H5 L 240 G.H5.20
Hydrophobic TM6 L 303 6x30 G.H5 V 246 G.H5.26
Van-der-waals TM6 L 303 6x30 G.H5 V 246 G.H5.26
Hydrophobic ICL2 F 175 34x51 G.H5 K 232 G.H5.12
Van-der-waals ICL2 F 175 34x51 G.H5 K 232 G.H5.12
Hydrophobic TM6 L 310 6x37 G.H5 L 245 G.H5.25
Polar TM3 R 167 3x50 G.H5 N 244 G.H5.24
Polar TM7 Y 369 7x53 G.H5 N 244 G.H5.24
Van-der-waals TM7 Y 369 7x53 G.H5 N 244 G.H5.24
Hydrophobic ICL2 K 178 34x54 G.S1 L 34 G.S1.02
Van-der-waals ICL2 K 178 34x54 G.S1 L 34 G.S1.02
Hydrophobic ICL2 K 178 34x54 G.H5 I 235 G.H5.15
Polar ICL1 S 100 - G.H5 E 242 G.H5.22
Van-der-waals ICL1 S 100 - G.H5 E 242 G.H5.22
Hydrophobic ICL2 F 175 34x51 G.S3 V 79 G.S3.01
Aromatic ICL2 F 175 34x51 G.H5 F 228 G.H5.08
Hydrophobic ICL2 F 175 34x51 G.H5 F 228 G.H5.08
Van-der-waals ICL2 F 175 34x51 G.H5 F 228 G.H5.08
Hydrophobic ICL2 F 175 34x51 G.H5 C 231 G.H5.11
Hydrophobic ICL2 T 179 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 R 167 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 167 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM6 G 306 6x33 G.H5 V 246 G.H5.26
Hydrophobic TM3 I 171 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM3 E 166 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 171 3x54 G.H5 N 239 G.H5.19
Hydrophobic TM6 H 305 6x32 G.H5 V 246 G.H5.26
Hydrophobic TM5 L 264 5x65 G.H5 L 240 G.H5.20
Polar C-term S 373 - G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 175 34x51 G.H5 I 235 G.H5.15
Van-der-waals ICL2 F 175 34x51 G.H5 I 235 G.H5.15
Polar C-term S 373 - G.H5 N 244 G.H5.24
Hydrophobic C-term S 373 - G.H5 N 244 G.H5.24
Van-der-waals C-term S 373 - G.H5 N 244 G.H5.24
Hydrophobic TM3 I 171 3x54 G.H5 L 236 G.H5.16
Van-der-waals TM3 I 171 3x54 G.H5 L 236 G.H5.16
Polar ICL2 K 178 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 A 170 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 170 3x53 G.H5 Y 243 G.H5.23
Polar TM3 A 170 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 239 G.H5.19
Polar TM6 H 305 6x32 G.H5 L 245 G.H5.25
Hydrophobic TM6 H 305 6x32 G.H5 L 245 G.H5.25
Van-der-waals TM6 H 305 6x32 G.H5 L 245 G.H5.25