Refined structure (7XK8) of Gi1 - NMU2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (63.6%), 129 from model (36.4%)
Residue sidechains - 185 from structure (52.3%), 169 from model (47.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure AF2
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure AF2
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure AF2
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 Structure Structure
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure AF2
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure AF2
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure AF2
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure AF2
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure AF2
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure AF2
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure AF2
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure AF2
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure AF2
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure AF2
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure AF2
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 279 from structure (78.4%), 77 from model (21.6%)
Residue sidechains - 237 from structure (66.6%), 119 from model (33.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 M - AF2 AF2
N-term 5 E - AF2 AF2
N-term 6 K - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 Q - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 W - AF2 AF2
N-term 13 I - AF2 AF2
N-term 14 Y - AF2 AF2
N-term 15 Q - AF2 AF2
N-term 16 Q - AF2 AF2
N-term 17 K - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 D - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 F - AF2 AF2
N-term 23 Q - AF2 AF2
N-term 24 K - AF2 AF2
N-term 25 H - AF2 AF2
N-term 26 L - AF2 AF2
N-term 27 N - AF2 AF2
N-term 28 S - AF2 AF2
N-term 29 T - AF2 AF2
N-term 30 E - AF2 AF2
N-term 31 E - AF2 AF2
N-term 32 Y - AF2 AF2
N-term 33 L - AF2 AF2
N-term 34 A - AF2 AF2
N-term 35 F - AF2 AF2
N-term 36 L - AF2 AF2
N-term 37 C - AF2 AF2
N-term 38 G - AF2 AF2
N-term 39 P - AF2 AF2
N-term 40 R - AF2 AF2
TM1 41 R 1.28x28 AF2 AF2
TM1 42 S 1.29x29 AF2 AF2
TM1 43 H 1.30x30 AF2 AF2
TM1 44 F 1.31x31 AF2 AF2
TM1 45 F 1.32x32 Structure Structure
TM1 46 L 1.33x33 Structure Structure
TM1 47 P 1.34x34 Structure Structure
TM1 48 V 1.35x35 Structure Structure
TM1 49 S 1.36x36 Structure Structure
TM1 50 V 1.37x37 Structure AF2
TM1 51 V 1.38x38 Structure Structure
TM1 52 Y 1.39x39 Structure Structure
TM1 53 V 1.40x40 Structure AF2
TM1 54 P 1.41x41 Structure Structure
TM1 55 I 1.42x42 Structure Structure
TM1 56 F 1.43x43 Structure AF2
TM1 57 V 1.44x44 Structure AF2
TM1 58 V 1.45x45 Structure Structure
TM1 59 G 1.46x46 Structure Structure
TM1 60 V 1.47x47 Structure Structure
TM1 61 I 1.48x48 Structure AF2
TM1 62 G 1.49x49 Structure Structure
TM1 63 N 1.50x50 Structure Structure
TM1 64 V 1.51x51 Structure AF2
TM1 65 L 1.52x52 Structure AF2
TM1 66 V 1.53x53 Structure Structure
TM1 67 C 1.54x54 Structure Structure
TM1 68 L 1.55x55 Structure AF2
TM1 69 V 1.56x56 Structure Structure
TM1 70 I 1.57x57 Structure Structure
TM1 71 L 1.58x58 Structure AF2
TM1 72 Q 1.59x59 Structure Structure
TM1 73 H 1.60x60 Structure AF2
ICL1 74 Q 12.48x48 Structure AF2
ICL1 75 A 12.49x49 Structure Structure
ICL1 76 M 12.50x50 Structure AF2
ICL1 77 K 12.51x51 Structure AF2
TM2 78 T 2.37x37 Structure Structure
TM2 79 P 2.38x38 Structure Structure
TM2 80 T 2.39x39 Structure Structure
TM2 81 N 2.40x40 Structure AF2
TM2 82 Y 2.41x41 Structure Structure
TM2 83 Y 2.42x42 Structure Structure
TM2 84 L 2.43x43 Structure Structure
TM2 85 F 2.44x44 Structure AF2
TM2 86 S 2.45x45 Structure Structure
TM2 87 L 2.46x46 Structure Structure
TM2 88 A 2.47x47 Structure Structure
TM2 89 V 2.48x48 Structure Structure
TM2 90 S 2.49x49 Structure Structure
TM2 91 D 2.50x50 Structure AF2
TM2 92 L 2.51x51 Structure Structure
TM2 93 L 2.52x52 Structure Structure
TM2 94 V 2.53x53 Structure Structure
TM2 95 L 2.54x54 Structure Structure
TM2 96 L 2.55x55 Structure Structure
TM2 97 L 2.56x551 Structure Structure
TM2 98 G 2.57x56 Structure Structure
TM2 99 M 2.58x57 Structure Structure
TM2 100 P 2.59x58 Structure Structure
TM2 101 L 2.60x59 Structure Structure
TM2 102 E 2.61x60 Structure Structure
TM2 103 V 2.62x61 Structure Structure
TM2 104 Y 2.63x62 Structure Structure
TM2 105 E 2.64x63 Structure Structure
TM2 106 M 2.65x64 Structure AF2
TM2 107 W 2.66x65 Structure Structure
TM2 108 R 2.67x66 Structure Structure
TM2 109 N 2.68x67 Structure Structure
ECL1 110 Y - Structure Structure
ECL1 111 P 23.49x49 Structure Structure
ECL1 112 F 23.50x50 Structure AF2
ECL1 113 L 23.51x51 Structure Structure
ECL1 114 F 23.52x52 Structure Structure
TM3 115 G 3.21x21 Structure Structure
TM3 116 P 3.22x22 Structure Structure
TM3 117 V 3.23x23 Structure AF2
TM3 118 G 3.24x24 Structure Structure
TM3 119 C 3.25x25 Structure Structure
TM3 120 Y 3.26x26 Structure Structure
TM3 121 F 3.27x27 Structure AF2
TM3 122 K 3.28x28 Structure Structure
TM3 123 T 3.29x29 Structure Structure
TM3 124 A 3.30x30 Structure Structure
TM3 125 L 3.31x31 Structure Structure
TM3 126 F 3.32x32 Structure Structure
TM3 127 E 3.33x33 Structure Structure
TM3 128 T 3.34x34 Structure Structure
TM3 129 V 3.35x35 Structure Structure
TM3 130 C 3.36x36 Structure Structure
TM3 131 F 3.37x37 Structure AF2
TM3 132 A 3.38x38 Structure Structure
TM3 133 S 3.39x39 Structure Structure
TM3 134 I 3.40x40 Structure Structure
TM3 135 L 3.41x41 Structure Structure
TM3 136 S 3.42x42 Structure Structure
TM3 137 I 3.43x43 Structure Structure
TM3 138 T 3.44x44 Structure Structure
TM3 139 T 3.45x45 Structure Structure
TM3 140 V 3.46x46 Structure Structure
TM3 141 S 3.47x47 Structure Structure
TM3 142 V 3.48x48 Structure Structure
TM3 143 E 3.49x49 Structure Structure
TM3 144 R 3.50x50 Structure Structure
TM3 145 Y 3.51x51 Structure Structure
TM3 146 V 3.52x52 Structure Structure
TM3 147 A 3.53x53 Structure Structure
TM3 148 I 3.54x54 Structure Structure
TM3 149 L 3.55x55 Structure Structure
TM3 150 H 3.56x56 Structure Structure
ICL2 151 P 34.50x50 Structure Structure
ICL2 152 F 34.51x51 Structure Structure
ICL2 153 R 34.52x52 Structure Structure
ICL2 154 A 34.53x53 Structure Structure
ICL2 155 K 34.54x54 Structure AF2
ICL2 156 L 34.55x55 Structure Structure
ICL2 157 Q 34.56x56 Structure AF2
ICL2 158 S 34.57x57 Structure Structure
TM4 159 T 4.38x38 Structure Structure
TM4 160 R 4.39x39 Structure Structure
TM4 161 R 4.40x40 Structure AF2
TM4 162 R 4.41x41 Structure Structure
TM4 163 A 4.42x42 Structure Structure
TM4 164 L 4.43x43 Structure Structure
TM4 165 R 4.44x44 Structure AF2
TM4 166 I 4.45x45 Structure Structure
TM4 167 L 4.46x46 Structure Structure
TM4 168 G 4.47x47 Structure Structure
TM4 169 I 4.48x48 Structure Structure
TM4 170 V 4.49x49 Structure Structure
TM4 171 W 4.50x50 Structure Structure
TM4 172 G 4.51x51 Structure Structure
TM4 173 F 4.52x52 Structure Structure
TM4 174 S 4.53x53 Structure Structure
TM4 175 V 4.54x54 Structure Structure
TM4 176 L 4.55x55 Structure AF2
TM4 177 F 4.56x56 Structure Structure
TM4 178 S 4.57x57 Structure Structure
TM4 179 L 4.58x59 Structure Structure
TM4 180 P 4.59x60 Structure Structure
TM4 181 N 4.60x61 Structure Structure
TM4 182 T 4.61x62 Structure Structure
TM4 183 S 4.62x63 Structure Structure
TM4 184 I 4.63x64 Structure Structure
TM4 185 H 4.64x65 Structure Structure
ECL2 186 G - Structure Structure
ECL2 187 I - Structure Structure
ECL2 188 K - Structure Structure
ECL2 189 F - Structure Structure
ECL2 190 H - Structure AF2
ECL2 191 Y - Structure Structure
ECL2 192 F - Structure Structure
ECL2 193 P - Structure Structure
ECL2 194 N - Structure Structure
ECL2 195 G - Structure Structure
ECL2 196 S - Structure Structure
ECL2 197 L - Structure Structure
ECL2 198 V - Structure Structure
ECL2 199 P - Structure Structure
ECL2 200 G - Structure Structure
ECL2 201 S - Structure Structure
ECL2 202 A - Structure Structure
ECL2 203 T - Structure Structure
ECL2 204 C 45.50x50 Structure Structure
ECL2 205 T 45.51x51 Structure Structure
ECL2 206 V 45.52x52 Structure Structure
ECL2 207 I - Structure AF2
ECL2 208 K - Structure AF2
ECL2 209 P - Structure Structure
ECL2 210 M - Structure Structure
ECL2 211 W - Structure Structure
TM5 212 I 5.34x34 Structure Structure
TM5 213 Y 5.35x35 Structure Structure
TM5 214 N 5.36x36 Structure Structure
TM5 215 F 5.37x37 Structure Structure
TM5 216 I 5.38x38 Structure Structure
TM5 217 I 5.39x39 Structure AF2
TM5 218 Q 5.40x40 Structure Structure
TM5 219 V 5.41x41 Structure Structure
TM5 220 T 5.42x42 Structure Structure
TM5 221 S 5.43x43 Structure Structure
TM5 222 F 5.44x44 Structure Structure
TM5 223 L 5.45x45 Structure Structure
TM5 224 F 5.46x46 Structure Structure
TM5 225 Y 5.47x47 Structure Structure
TM5 226 L 5.48x48 Structure Structure
TM5 227 L 5.49x49 Structure Structure
TM5 228 P 5.50x50 Structure Structure
TM5 229 M 5.51x51 Structure Structure
TM5 230 T 5.52x52 Structure Structure
TM5 231 V 5.53x53 Structure Structure
TM5 232 I 5.54x54 Structure Structure
TM5 233 S 5.55x55 Structure Structure
TM5 234 V 5.56x56 Structure Structure
TM5 235 L 5.57x57 Structure Structure
TM5 236 Y 5.58x58 Structure Structure
TM5 237 Y 5.59x59 Structure AF2
TM5 238 L 5.60x60 Structure Structure
TM5 239 M 5.61x61 Structure Structure
TM5 240 A 5.62x62 Structure Structure
TM5 241 L 5.63x63 Structure Structure
TM5 242 R 5.64x64 Structure Structure
TM5 243 L 5.65x65 Structure Structure
TM5 244 K 5.66x66 Structure AF2
TM5 245 K 5.67x67 Structure AF2
TM5 246 D 5.68x68 Structure Structure
TM5 247 K 5.69x69 Structure AF2
TM5 248 S 5.70x70 AF2 AF2
TM5 249 L 5.71x71 AF2 AF2
TM5 250 E 5.72x72 AF2 AF2
TM5 251 A 5.73x73 AF2 AF2
ICL3 252 D - AF2 AF2
ICL3 253 E - AF2 AF2
ICL3 254 G - AF2 AF2
TM6 255 N 6.22x22 AF2 AF2
TM6 256 A 6.23x23 AF2 AF2
TM6 257 N 6.24x24 AF2 AF2
TM6 258 I 6.25x25 Structure Structure
TM6 259 Q 6.26x26 Structure AF2
TM6 260 R 6.27x27 Structure AF2
TM6 261 P 6.28x28 Structure Structure
TM6 262 C 6.29x29 Structure Structure
TM6 263 R 6.30x30 Structure Structure
TM6 264 K 6.31x31 Structure AF2
TM6 265 S 6.32x32 Structure Structure
TM6 266 V 6.33x33 Structure Structure
TM6 267 N 6.34x34 Structure Structure
TM6 268 K 6.35x35 Structure Structure
TM6 269 M 6.36x36 Structure Structure
TM6 270 L 6.37x37 Structure Structure
TM6 271 F 6.38x38 Structure AF2
TM6 272 V 6.39x39 Structure Structure
TM6 273 L 6.40x40 Structure Structure
TM6 274 V 6.41x41 Structure Structure
TM6 275 L 6.42x42 Structure AF2
TM6 276 V 6.43x43 Structure Structure
TM6 277 F 6.44x44 Structure Structure
TM6 278 A 6.45x45 Structure Structure
TM6 279 I 6.46x46 Structure AF2
TM6 280 C 6.47x47 Structure Structure
TM6 281 W 6.48x48 Structure Structure
TM6 282 A 6.49x49 Structure Structure
TM6 283 P 6.50x50 Structure Structure
TM6 284 F 6.51x51 Structure Structure
TM6 285 H 6.52x52 Structure Structure
TM6 286 I 6.53x53 Structure Structure
TM6 287 D 6.54x54 Structure Structure
TM6 288 R 6.55x55 Structure Structure
TM6 289 L 6.56x56 Structure Structure
TM6 290 F 6.57x57 Structure AF2
TM6 291 F 6.58x58 Structure Structure
TM6 292 S 6.59x59 Structure Structure
TM6 293 F 6.60x60 Structure Structure
TM6 294 V 6.61x61 Structure Structure
ECL3 295 E - Structure Structure
ECL3 296 E - Structure Structure
ECL3 297 W - Structure Structure
ECL3 298 S - Structure Structure
TM7 299 E 7.25x24 Structure Structure
TM7 300 S 7.26x25 Structure Structure
TM7 301 L 7.27x26 Structure Structure
TM7 302 A 7.28x27 Structure Structure
TM7 303 A 7.29x28 Structure Structure
TM7 304 V 7.30x29 Structure Structure
TM7 305 F 7.31x30 Structure Structure
TM7 306 N 7.32x31 Structure Structure
TM7 307 L 7.33x32 Structure Structure
TM7 308 V 7.34x33 Structure Structure
TM7 309 H 7.35x34 Structure Structure
TM7 310 V 7.36x35 Structure Structure
TM7 311 V 7.37x36 Structure Structure
TM7 312 S 7.38x37 Structure Structure
TM7 313 G 7.39x38 Structure Structure
TM7 314 V 7.40x39 Structure Structure
TM7 315 F 7.41x40 Structure Structure
TM7 316 F 7.42x41 Structure Structure
TM7 317 Y 7.43x42 Structure AF2
TM7 318 L 7.44x43 Structure Structure
TM7 319 S 7.45x45 Structure Structure
TM7 320 S 7.46x46 Structure Structure
TM7 321 A 7.47x47 Structure Structure
TM7 322 V 7.48x48 Structure Structure
TM7 323 N 7.49x49 Structure Structure
TM7 324 P 7.50x50 Structure Structure
TM7 325 I 7.51x51 Structure Structure
TM7 326 I 7.52x52 Structure Structure
TM7 327 Y 7.53x53 Structure Structure
TM7 328 N 7.54x54 Structure Structure
TM7 329 L 7.55x55 Structure Structure
TM7 330 L 7.56x56 Structure Structure
H8 331 S 8.47x47 Structure Structure
H8 332 R 8.48x48 Structure Structure
H8 333 R 8.49x49 Structure Structure
H8 334 F 8.50x50 AF2 AF2
H8 335 Q 8.51x51 AF2 AF2
H8 336 A 8.52x52 AF2 AF2
H8 337 A 8.53x53 AF2 AF2
H8 338 F 8.54x54 AF2 AF2
H8 339 Q 8.55x55 AF2 AF2
H8 340 N 8.56x56 AF2 AF2
H8 341 V 8.57x57 AF2 AF2
H8 342 I 8.58x58 AF2 AF2
H8 343 S 8.59x59 AF2 AF2
H8 344 S 8.60x60 AF2 AF2
H8 345 F 8.61x61 AF2 AF2
H8 346 H 8.62x62 AF2 AF2
C-term 347 K - AF2 AF2
C-term 348 Q - AF2 AF2
C-term 349 W - AF2 AF2
C-term 350 H - AF2 AF2
C-term 351 S - AF2 AF2
C-term 352 Q - AF2 AF2
C-term 353 H - AF2 AF2
C-term 354 D - AF2 AF2
C-term 355 P - AF2 AF2
C-term 356 Q - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 R 333 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM6 C 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 T 80 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 152 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 152 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 243 5x65 G.H5 L 348 G.H5.20
Polar TM6 N 255 6x22 G.S6 H 322 G.S6.04
Hydrophobic TM6 N 255 6x22 G.S6 H 322 G.S6.04
Van-der-waals TM6 N 255 6x22 G.S6 H 322 G.S6.04
Hydrophobic TM6 V 266 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 266 6x33 G.H5 L 353 G.H5.25
Polar H8 S 331 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 S 331 8x47 G.H5 F 354 G.H5.26
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 156 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 L 156 34x55 G.HN E 28 G.HN.52
Hydrophobic TM5 M 239 5x61 G.H5 L 353 G.H5.25
Ionic TM6 R 263 6x30 G.H5 D 341 G.H5.13
Polar TM2 T 80 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 80 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 80 2x39 G.H5 D 350 G.H5.22
Polar H8 R 333 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 R 333 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 R 333 8x49 G.H5 K 349 G.H5.21
Polar TM2 T 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 78 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 78 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 N 255 6x22 G.H5 F 334 G.H5.06
Hydrophobic ICL2 L 156 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 156 34x55 G.hns1 R 32 G.hns1.03
Polar H8 S 331 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 151 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 151 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 I 258 6x25 G.S6 Y 320 G.S6.02
Van-der-waals TM6 I 258 6x25 G.S6 Y 320 G.S6.02
Polar TM6 Q 259 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 263 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 148 3x54 G.H5 I 344 G.H5.16
Polar H8 R 333 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 R 333 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 R 333 8x49 G.H5 F 354 G.H5.26
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 351 G.H5.23
Ionic ICL3 E 253 - G.s2s3 K 192 G.s2s3.01
Polar TM3 E 143 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 143 3x49 G.H5 C 351 G.H5.23
Hydrophobic H8 F 334 8x50 G.H5 G 352 G.H5.24
Hydrophobic ICL2 Q 157 34x56 G.HN E 28 G.HN.52
Van-der-waals ICL2 Q 157 34x56 G.HN E 28 G.HN.52
Hydrophobic TM6 Q 259 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 Q 259 6x26 G.H5 K 345 G.H5.17
Hydrophobic ICL2 F 152 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 152 34x51 G.S3 L 194 G.S3.01
Polar ICL3 E 253 - G.H5 Q 333 G.H5.05
Hydrophobic ICL3 E 253 - G.H5 Q 333 G.H5.05
Van-der-waals ICL3 E 253 - G.H5 Q 333 G.H5.05
Hydrophobic ICL3 E 253 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 E 253 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 151 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 151 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 156 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 156 34x55 G.hns1 A 31 G.hns1.02
Polar TM3 I 148 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 148 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 348 G.H5.20