Refined structure (7CFN) of Gs - GPBA receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 232 from structure (58.9%), 162 from model (41.1%)
Residue sidechains - 221 from structure (56.1%), 173 from model (43.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure AF2
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 274 from structure (89.5%), 32 from model (10.5%)
Residue sidechains - 272 from structure (88.9%), 34 from model (11.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 T - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 G - AF2 AF2
N-term 8 E - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 P - AF2 AF2
N-term 13 I - AF2 AF2
TM1 14 P 1.32x32 AF2 AF2
TM1 15 K 1.33x33 AF2 AF2
TM1 16 G 1.34x34 AF2 AF2
TM1 17 A 1.35x35 AF2 AF2
TM1 18 L 1.36x36 Structure Structure
TM1 19 G 1.37x37 Structure Structure
TM1 20 L 1.38x38 Structure Structure
TM1 21 S 1.39x39 Structure Structure
TM1 22 L 1.40x40 Structure Structure
TM1 23 A 1.41x41 Structure Structure
TM1 24 L 1.42x42 Structure Structure
TM1 25 A 1.43x43 Structure Structure
TM1 26 S 1.44x44 Structure Structure
TM1 27 L 1.45x45 Structure Structure
TM1 28 I 1.46x46 Structure Structure
TM1 29 I 1.47x47 Structure Structure
TM1 30 T 1.48x48 Structure Structure
TM1 31 A 1.49x49 Structure Structure
TM1 32 N 1.50x50 Structure Structure
TM1 33 L 1.51x51 Structure Structure
TM1 34 L 1.52x52 Structure Structure
TM1 35 L 1.53x53 Structure Structure
TM1 36 A 1.54x54 Structure Structure
TM1 37 L 1.55x55 Structure Structure
TM1 38 G 1.56x56 Structure Structure
TM1 39 I 1.57x57 Structure Structure
TM1 40 A 1.58x58 Structure Structure
TM1 41 W 1.59x59 Structure Structure
TM1 42 D 1.60x60 Structure Structure
ICL1 43 R 12.48x48 Structure Structure
ICL1 44 R 12.49x49 Structure Structure
ICL1 45 L 12.50x50 Structure Structure
ICL1 46 R 12.51x51 Structure Structure
TM2 47 S 2.36x36 Structure Structure
TM2 48 P 2.37x37 Structure Structure
TM2 49 P 2.38x38 Structure Structure
TM2 50 A 2.39x39 Structure Structure
TM2 51 G 2.40x40 Structure Structure
TM2 52 C 2.41x41 Structure Structure
TM2 53 F 2.42x42 Structure Structure
TM2 54 F 2.43x43 Structure Structure
TM2 55 L 2.44x44 Structure Structure
TM2 56 S 2.45x45 Structure Structure
TM2 57 L 2.46x46 Structure Structure
TM2 58 L 2.47x47 Structure Structure
TM2 59 L 2.48x48 Structure Structure
TM2 60 A 2.49x49 Structure Structure
TM2 61 G 2.50x50 Structure Structure
TM2 62 L 2.51x51 Structure Structure
TM2 63 L 2.52x52 Structure Structure
TM2 64 T 2.53x53 Structure Structure
TM2 65 G 2.54x54 Structure Structure
TM2 66 L 2.55x55 Structure Structure
TM2 67 A 2.56x56 Structure Structure
TM2 68 L 2.57x57 Structure Structure
TM2 69 P 2.58x58 Structure Structure
TM2 70 T 2.59x59 Structure Structure
TM2 71 L 2.60x60 Structure Structure
TM2 72 P 2.61x61 Structure Structure
TM2 73 G 2.62x62 Structure Structure
TM2 74 L 2.63x63 Structure Structure
ECL1 75 W - Structure Structure
ECL1 76 N - Structure AF2
ECL1 77 Q - Structure Structure
ECL1 78 S - Structure Structure
ECL1 79 R - Structure AF2
ECL1 80 R - Structure Structure
TM3 81 G 3.21x21 Structure Structure
TM3 82 Y 3.22x22 Structure Structure
TM3 83 W 3.23x23 Structure Structure
TM3 84 S 3.24x24 Structure Structure
TM3 85 C 3.25x25 Structure Structure
TM3 86 L 3.26x26 Structure Structure
TM3 87 L 3.27x27 Structure Structure
TM3 88 V 3.28x28 Structure Structure
TM3 89 Y 3.29x29 Structure Structure
TM3 90 L 3.30x30 Structure Structure
TM3 91 A 3.31x31 Structure Structure
TM3 92 P 3.32x32 Structure Structure
TM3 93 N 3.33x33 Structure Structure
TM3 94 F 3.34x34 Structure Structure
TM3 95 S 3.35x35 Structure Structure
TM3 96 F 3.36x36 Structure Structure
TM3 97 L 3.37x37 Structure Structure
TM3 98 S 3.38x38 Structure Structure
TM3 99 L 3.39x39 Structure Structure
TM3 100 L 3.40x40 Structure Structure
TM3 101 A 3.41x41 Structure Structure
TM3 102 N 3.42x42 Structure Structure
TM3 103 L 3.43x43 Structure Structure
TM3 104 L 3.44x44 Structure Structure
TM3 105 L 3.45x45 Structure Structure
TM3 106 V 3.46x46 Structure Structure
TM3 107 H 3.47x47 Structure Structure
TM3 108 G 3.48x48 Structure Structure
TM3 109 E 3.49x49 Structure Structure
TM3 110 R 3.50x50 Structure Structure
TM3 111 Y 3.51x51 Structure Structure
TM3 112 M 3.52x52 Structure Structure
TM3 113 A 3.53x53 Structure Structure
TM3 114 V 3.54x54 Structure Structure
TM3 115 L 3.55x55 Structure Structure
TM3 116 R 3.56x56 Structure Structure
ICL2 117 P - Structure Structure
ICL2 118 L - Structure Structure
ICL2 119 Q - Structure Structure
ICL2 120 P - Structure Structure
ICL2 121 P - Structure Structure
ICL2 122 G - Structure Structure
TM4 123 S 4.41x41 Structure Structure
TM4 124 I 4.42x42 Structure Structure
TM4 125 R 4.43x43 Structure Structure
TM4 126 L 4.44x44 Structure Structure
TM4 127 A 4.45x45 Structure Structure
TM4 128 L 4.46x46 Structure Structure
TM4 129 L 4.47x47 Structure Structure
TM4 130 L 4.48x48 Structure Structure
TM4 131 T 4.49x49 Structure Structure
TM4 132 W 4.50x50 Structure Structure
TM4 133 A 4.51x51 Structure Structure
TM4 134 G 4.52x52 Structure Structure
TM4 135 P 4.53x53 Structure Structure
TM4 136 L 4.54x54 Structure Structure
TM4 137 L 4.55x55 Structure Structure
TM4 138 F 4.56x56 Structure Structure
TM4 139 A 4.57x57 Structure Structure
TM4 140 S 4.58x58 Structure Structure
TM4 141 L 4.59x59 Structure Structure
TM4 142 P 4.60x60 Structure Structure
TM4 143 A 4.61x61 Structure Structure
TM4 144 L 4.62x62 Structure Structure
TM4 145 G 4.63x63 Structure Structure
ECL2 146 W - Structure Structure
ECL2 147 N - Structure Structure
ECL2 148 H - Structure Structure
ECL2 149 W - Structure Structure
ECL2 150 T - Structure Structure
ECL2 151 P - Structure Structure
ECL2 152 G - Structure Structure
ECL2 153 A - Structure Structure
ECL2 154 N - Structure Structure
ECL2 155 C 45.50x50 Structure Structure
ECL2 156 S 45.51x51 Structure Structure
ECL2 157 S 45.52x52 Structure Structure
ECL2 158 Q - Structure Structure
ECL2 159 A - Structure Structure
ECL2 160 I - Structure Structure
ECL2 161 F - Structure Structure
TM5 162 P 5.35x36 Structure Structure
TM5 163 A 5.36x37 Structure Structure
TM5 164 P 5.37x38 Structure Structure
TM5 165 Y 5.38x39 Structure Structure
TM5 166 L 5.39x40 Structure Structure
TM5 167 Y 5.40x41 Structure Structure
TM5 168 L 5.41x42 Structure Structure
TM5 169 E 5.42x43 Structure Structure
TM5 170 V 5.43x44 Structure Structure
TM5 171 Y 5.44x45 Structure Structure
TM5 172 G 5.45x46 Structure Structure
TM5 173 L 5.46x461 Structure Structure
TM5 174 L 5.47x47 Structure Structure
TM5 175 L 5.48x48 Structure Structure
TM5 176 P 5.49x49 Structure Structure
TM5 177 A 5.50x50 Structure Structure
TM5 178 V 5.51x51 Structure Structure
TM5 179 G 5.52x52 Structure Structure
TM5 180 A 5.53x53 Structure Structure
TM5 181 A 5.54x54 Structure Structure
TM5 182 A 5.55x55 Structure Structure
TM5 183 F 5.56x56 Structure Structure
TM5 184 L 5.57x57 Structure Structure
TM5 185 S 5.58x58 Structure Structure
TM5 186 V 5.59x59 Structure Structure
TM5 187 R 5.60x60 Structure Structure
TM5 188 V 5.61x61 Structure Structure
TM5 189 L 5.62x62 Structure Structure
TM5 190 A 5.63x63 Structure Structure
TM5 191 T 5.64x64 Structure Structure
TM5 192 A 5.65x65 Structure Structure
TM5 193 H 5.66x66 Structure Structure
TM5 194 R 5.67x67 Structure Structure
TM5 195 Q 5.68x68 Structure Structure
TM5 196 L 5.69x69 Structure Structure
TM5 197 Q 5.70x70 Structure Structure
TM5 198 D 5.71x71 Structure Structure
TM5 199 I 5.72x72 Structure Structure
TM5 200 C 5.73x73 Structure Structure
TM5 201 R 5.74x74 Structure Structure
TM5 202 L 5.75x75 Structure Structure
TM5 203 E 5.76x76 Structure Structure
TM5 204 R 5.77x77 Structure Structure
TM5 205 A 5.78x78 Structure Structure
TM5 206 V 5.79x79 Structure Structure
TM5 207 C 5.80x80 Structure Structure
ICL3 208 R - Structure Structure
ICL3 209 D - Structure Structure
ICL3 210 E - Structure Structure
ICL3 211 P - Structure Structure
TM6 212 S 6.23x23 Structure Structure
TM6 213 A 6.24x24 Structure Structure
TM6 214 L 6.25x25 Structure Structure
TM6 215 A 6.26x26 Structure Structure
TM6 216 R 6.27x27 Structure Structure
TM6 217 A 6.28x28 Structure Structure
TM6 218 L 6.29x29 Structure Structure
TM6 219 T 6.30x30 Structure Structure
TM6 220 W 6.31x31 Structure Structure
TM6 221 R 6.32x32 Structure Structure
TM6 222 Q 6.33x33 Structure Structure
TM6 223 A 6.34x34 Structure Structure
TM6 224 R 6.35x35 Structure Structure
TM6 225 A 6.36x36 Structure Structure
TM6 226 Q 6.37x37 Structure Structure
TM6 227 A 6.38x38 Structure Structure
TM6 228 G 6.39x39 Structure Structure
TM6 229 A 6.40x40 Structure Structure
TM6 230 M 6.41x41 Structure Structure
TM6 231 L 6.42x42 Structure Structure
TM6 232 L 6.43x43 Structure Structure
TM6 233 F 6.44x44 Structure Structure
TM6 234 G 6.45x45 Structure Structure
TM6 235 L 6.46x46 Structure Structure
TM6 236 C 6.47x47 Structure Structure
TM6 237 W 6.48x48 Structure Structure
TM6 238 G 6.49x49 Structure Structure
TM6 239 P 6.50x50 Structure Structure
TM6 240 Y 6.51x51 Structure Structure
TM6 241 V 6.52x52 Structure Structure
TM6 242 A 6.53x53 Structure Structure
TM6 243 T 6.54x54 Structure Structure
TM6 244 L 6.55x55 Structure Structure
TM6 245 L 6.56x56 Structure Structure
TM6 246 L 6.57x57 Structure Structure
TM6 247 S 6.58x58 Structure Structure
TM6 248 V 6.59x59 Structure Structure
TM6 249 L 6.60x60 Structure Structure
TM6 250 A 6.61x61 Structure Structure
TM6 251 Y 6.62x62 Structure Structure
TM6 252 E 6.63x63 Structure Structure
TM6 253 Q 6.64x64 Structure Structure
ECL3 254 R - Structure Structure
ECL3 255 P - Structure Structure
ECL3 256 P - Structure Structure
ECL3 257 L - Structure Structure
TM7 258 G 7.31x30 Structure Structure
TM7 259 P 7.32x31 Structure Structure
TM7 260 G 7.33x32 Structure Structure
TM7 261 T 7.34x33 Structure Structure
TM7 262 L 7.35x34 Structure Structure
TM7 263 L 7.36x35 Structure Structure
TM7 264 S 7.37x36 Structure Structure
TM7 265 L 7.38x37 Structure Structure
TM7 266 L 7.39x38 Structure Structure
TM7 267 S 7.40x39 Structure Structure
TM7 268 L 7.41x40 Structure Structure
TM7 269 G 7.42x41 Structure Structure
TM7 270 S 7.43x42 Structure Structure
TM7 271 A 7.44x43 Structure Structure
TM7 272 S 7.45x45 Structure Structure
TM7 273 A 7.46x46 Structure Structure
TM7 274 A 7.47x47 Structure Structure
TM7 275 A 7.48x48 Structure Structure
TM7 276 V 7.49x49 Structure Structure
TM7 277 P 7.50x50 Structure Structure
TM7 278 V 7.51x51 Structure Structure
TM7 279 A 7.52x52 Structure Structure
TM7 280 M 7.53x53 Structure Structure
TM7 281 G 7.54x54 Structure Structure
TM7 282 L 7.55x55 Structure Structure
TM7 283 G 7.56x56 Structure Structure
H8 284 D 8.47x47 Structure Structure
H8 285 Q 8.48x48 Structure Structure
H8 286 R 8.49x49 Structure Structure
H8 287 Y 8.50x50 Structure Structure
H8 288 T 8.51x51 Structure Structure
H8 289 A 8.52x52 Structure Structure
H8 290 P 8.53x53 Structure Structure
H8 291 W 8.54x54 Structure Structure
H8 292 R 8.55x55 AF2 AF2
H8 293 A 8.56x56 AF2 AF2
H8 294 A 8.57x57 AF2 AF2
H8 295 A 8.58x58 AF2 AF2
H8 296 Q 8.59x59 AF2 AF2
C-term 297 R - AF2 AF2
C-term 298 C - AF2 AF2
C-term 299 L - AF2 AF2
C-term 300 Q - AF2 AF2
C-term 301 G - AF2 AF2
C-term 302 L - AF2 AF2
C-term 303 W - AF2 AF2
C-term 304 G - AF2 AF2
C-term 305 R - AF2 AF2
C-term 306 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 Q 222 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 Q 222 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 205 5x78 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 L 218 6x29 G.H5 L 394 G.H5.26
Polar TM6 R 221 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 221 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 221 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 117 - G.H5 I 383 G.H5.15
Hydrophobic TM5 A 192 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 192 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 118 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 118 - G.H5 I 383 G.H5.15
Polar TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 196 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM6 A 225 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 225 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 206 5x79 G.H4 L 346 G.H4.16
Van-der-waals TM5 V 206 5x79 G.H4 L 346 G.H4.16
Ionic H8 R 286 8x49 G.H5 E 392 G.H5.24
Polar H8 R 286 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 R 286 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 R 286 8x49 G.H5 E 392 G.H5.24
Polar TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Polar ICL3 R 208 - G.hgh4 T 319 G.hgh4.09
Van-der-waals ICL3 R 208 - G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 L 202 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM3 V 114 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 114 3x54 G.H5 L 388 G.H5.20
Polar TM6 R 221 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 221 6x32 G.H5 L 394 G.H5.26
Hydrophobic H8 D 284 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 D 284 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 118 - G.S3 V 217 G.S3.01
Hydrophobic TM5 I 199 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 202 5x75 G.H4 R 342 G.H4.12
Hydrophobic ICL2 L 118 - G.H5 R 380 G.H5.12
Hydrophobic TM2 A 50 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 202 5x75 G.S6 P 361 G.S6.03
Polar TM3 A 113 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 H 387 G.H5.19
Aromatic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Ionic TM5 D 198 5x71 G.H5 R 385 G.H5.17
Van-der-waals TM5 D 198 5x71 G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 208 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic ICL2 P 117 - G.H5 Q 384 G.H5.16
Polar H8 Q 285 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 285 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 285 8x48 G.H5 E 392 G.H5.24
Ionic ICL3 R 208 - G.H4 D 343 G.H4.13
Hydrophobic TM3 A 113 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 Q 195 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 195 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 214 6x25 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM5 V 206 5x79 G.H4 D 343 G.H4.13
Hydrophobic ICL2 L 118 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 118 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 P 117 - G.H5 H 387 G.H5.19
Hydrophobic TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 199 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 117 - G.H5 R 380 G.H5.12
Polar TM5 Q 195 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 E 203 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 L 214 6x25 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM5 L 189 5x62 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 189 5x62 G.H5 L 393 G.H5.25
Polar TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 V 114 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 118 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 118 - G.S1 H 41 G.S1.02
Hydrophobic TM6 L 214 6x25 G.h4s6 Y 358 G.h4s6.20