Refined structure (9IJE) of Gs - β3-adrenoceptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 224 from structure (56.9%), 170 from model (43.1%)
Residue sidechains - 197 from structure (50.0%), 197 from model (50.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure AF2
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure AF2
G.HN 20 R G.HN.37 Structure AF2
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure AF2
G.HN 23 N G.HN.40 Structure AF2
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure AF2
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure AF2
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure AF2
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure AF2
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure AF2
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure AF2
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure AF2
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure AF2
G.H5 370 E G.H5.02 Structure AF2
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure AF2
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 252 from structure (72.4%), 96 from model (27.6%)
Residue sidechains - 245 from structure (70.4%), 103 from model (29.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 W - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 H - AF2 AF2
N-term 7 E - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 A - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 W - AF2 AF2
N-term 15 P - AF2 AF2
N-term 16 D - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 T - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 P - AF2 AF2
N-term 23 N - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 A - AF2 AF2
N-term 26 N - AF2 AF2
N-term 27 T - AF2 AF2
N-term 28 S - AF2 AF2
N-term 29 G - AF2 AF2
TM1 30 L 1.25x25 AF2 AF2
TM1 31 P 1.26x26 AF2 AF2
TM1 32 G 1.27x27 AF2 AF2
TM1 33 V 1.28x28 AF2 AF2
TM1 34 P 1.29x29 AF2 AF2
TM1 35 W 1.30x30 AF2 AF2
TM1 36 E 1.31x31 AF2 AF2
TM1 37 A 1.32x32 AF2 AF2
TM1 38 A 1.33x33 AF2 AF2
TM1 39 L 1.34x34 AF2 AF2
TM1 40 A 1.35x35 AF2 AF2
TM1 41 G 1.36x36 AF2 AF2
TM1 42 A 1.37x37 Structure Structure
TM1 43 L 1.38x38 Structure Structure
TM1 44 L 1.39x39 Structure Structure
TM1 45 A 1.40x40 Structure Structure
TM1 46 L 1.41x41 Structure Structure
TM1 47 A 1.42x42 Structure Structure
TM1 48 V 1.43x43 Structure Structure
TM1 49 L 1.44x44 Structure Structure
TM1 50 A 1.45x45 Structure Structure
TM1 51 T 1.46x46 Structure Structure
TM1 52 V 1.47x47 Structure Structure
TM1 53 G 1.48x48 Structure Structure
TM1 54 G 1.49x49 Structure Structure
TM1 55 N 1.50x50 Structure Structure
TM1 56 L 1.51x51 Structure Structure
TM1 57 L 1.52x52 Structure Structure
TM1 58 V 1.53x53 Structure Structure
TM1 59 I 1.54x54 Structure Structure
TM1 60 V 1.55x55 Structure Structure
TM1 61 A 1.56x56 Structure Structure
TM1 62 I 1.57x57 Structure Structure
TM1 63 A 1.58x58 Structure Structure
TM1 64 W 1.59x59 Structure Structure
TM1 65 T 1.60x60 Structure Structure
ICL1 66 P 12.48x48 Structure Structure
ICL1 67 R 12.49x49 Structure Structure
ICL1 68 L 12.50x50 Structure Structure
ICL1 69 Q 12.51x51 Structure Structure
TM2 70 T 2.37x37 Structure Structure
TM2 71 M 2.38x38 Structure Structure
TM2 72 T 2.39x39 Structure Structure
TM2 73 N 2.40x40 Structure Structure
TM2 74 V 2.41x41 Structure Structure
TM2 75 F 2.42x42 Structure Structure
TM2 76 V 2.43x43 Structure Structure
TM2 77 T 2.44x44 Structure Structure
TM2 78 S 2.45x45 Structure Structure
TM2 79 L 2.46x46 Structure Structure
TM2 80 A 2.47x47 Structure Structure
TM2 81 A 2.48x48 Structure Structure
TM2 82 A 2.49x49 Structure Structure
TM2 83 D 2.50x50 Structure Structure
TM2 84 L 2.51x51 Structure Structure
TM2 85 V 2.52x52 Structure Structure
TM2 86 M 2.53x53 Structure Structure
TM2 87 G 2.54x54 Structure Structure
TM2 88 L 2.55x55 Structure Structure
TM2 89 L 2.56x551 Structure Structure
TM2 90 V 2.57x56 Structure Structure
TM2 91 V 2.58x57 Structure Structure
TM2 92 P 2.59x58 Structure Structure
TM2 93 P 2.60x59 Structure Structure
TM2 94 A 2.61x60 Structure Structure
TM2 95 A 2.62x61 Structure Structure
TM2 96 T 2.63x62 Structure Structure
TM2 97 L 2.64x63 Structure Structure
TM2 98 A 2.65x64 Structure Structure
TM2 99 L 2.66x65 Structure AF2
TM2 100 T 2.67x66 Structure Structure
TM2 101 G 2.68x67 Structure Structure
ECL1 102 H 23.49x49 Structure AF2
ECL1 103 W 23.50x50 Structure AF2
ECL1 104 P 23.51x51 Structure Structure
ECL1 105 L 23.52x52 Structure AF2
TM3 106 G 3.21x21 Structure Structure
TM3 107 A 3.22x22 Structure Structure
TM3 108 T 3.23x23 Structure Structure
TM3 109 G 3.24x24 Structure Structure
TM3 110 C 3.25x25 Structure Structure
TM3 111 E 3.26x26 Structure Structure
TM3 112 L 3.27x27 Structure Structure
TM3 113 W 3.28x28 Structure Structure
TM3 114 T 3.29x29 Structure Structure
TM3 115 S 3.30x30 Structure Structure
TM3 116 V 3.31x31 Structure Structure
TM3 117 D 3.32x32 Structure Structure
TM3 118 V 3.33x33 Structure Structure
TM3 119 L 3.34x34 Structure Structure
TM3 120 C 3.35x35 Structure Structure
TM3 121 V 3.36x36 Structure Structure
TM3 122 T 3.37x37 Structure Structure
TM3 123 A 3.38x38 Structure Structure
TM3 124 S 3.39x39 Structure Structure
TM3 125 I 3.40x40 Structure Structure
TM3 126 E 3.41x41 Structure AF2
TM3 127 T 3.42x42 Structure Structure
TM3 128 L 3.43x43 Structure Structure
TM3 129 C 3.44x44 Structure Structure
TM3 130 A 3.45x45 Structure Structure
TM3 131 L 3.46x46 Structure Structure
TM3 132 A 3.47x47 Structure Structure
TM3 133 V 3.48x48 Structure Structure
TM3 134 D 3.49x49 Structure Structure
TM3 135 R 3.50x50 Structure Structure
TM3 136 Y 3.51x51 Structure Structure
TM3 137 L 3.52x52 Structure Structure
TM3 138 A 3.53x53 Structure Structure
TM3 139 V 3.54x54 Structure Structure
TM3 140 T 3.55x55 Structure Structure
TM3 141 N 3.56x56 Structure Structure
ICL2 142 P 34.50x50 Structure Structure
ICL2 143 L 34.51x51 Structure Structure
ICL2 144 R 34.52x52 Structure Structure
ICL2 145 Y 34.53x53 Structure Structure
ICL2 146 G 34.54x54 Structure Structure
ICL2 147 A 34.55x55 Structure Structure
ICL2 148 L 34.56x56 Structure Structure
ICL2 149 V 34.57x57 Structure Structure
TM4 150 T 4.38x38 Structure Structure
TM4 151 K 4.39x39 Structure Structure
TM4 152 R 4.40x40 Structure AF2
TM4 153 C 4.41x41 Structure Structure
TM4 154 A 4.42x42 Structure Structure
TM4 155 R 4.43x43 Structure Structure
TM4 156 T 4.44x44 Structure Structure
TM4 157 A 4.45x45 Structure Structure
TM4 158 V 4.46x46 Structure Structure
TM4 159 V 4.47x47 Structure Structure
TM4 160 L 4.48x48 Structure Structure
TM4 161 V 4.49x49 Structure Structure
TM4 162 W 4.50x50 Structure Structure
TM4 163 V 4.51x51 Structure Structure
TM4 164 V 4.52x52 Structure Structure
TM4 165 S 4.53x53 Structure Structure
TM4 166 A 4.54x54 Structure Structure
TM4 167 A 4.55x55 Structure Structure
TM4 168 V 4.56x56 Structure Structure
TM4 169 S 4.57x57 Structure Structure
TM4 170 F 4.58x58 Structure Structure
TM4 171 A 4.59x59 Structure Structure
TM4 172 P 4.60x60 Structure Structure
TM4 173 I 4.61x61 Structure Structure
TM4 174 M 4.62x62 Structure Structure
TM4 175 S 4.63x63 Structure Structure
TM4 176 Q 4.64x64 AF2 AF2
ECL2 177 W - AF2 AF2
ECL2 178 W - AF2 AF2
ECL2 179 R - AF2 AF2
ECL2 180 V - AF2 AF2
ECL2 181 G - AF2 AF2
ECL2 182 A - AF2 AF2
ECL2 183 D - AF2 AF2
ECL2 184 A - AF2 AF2
ECL2 185 E - AF2 AF2
ECL2 186 A - AF2 AF2
ECL2 187 Q - AF2 AF2
ECL2 188 R - AF2 AF2
ECL2 189 C - AF2 AF2
ECL2 190 H - AF2 AF2
ECL2 191 S - AF2 AF2
ECL2 192 N - AF2 AF2
ECL2 193 P - AF2 AF2
ECL2 194 R - AF2 AF2
ECL2 195 C - AF2 AF2
ECL2 196 C 45.50x50 AF2 AF2
ECL2 197 A 45.51x51 AF2 AF2
ECL2 198 F 45.52x52 AF2 AF2
ECL2 199 A - AF2 AF2
ECL2 200 S - AF2 AF2
TM5 201 N 5.35x36 AF2 AF2
TM5 202 M 5.36x37 Structure Structure
TM5 203 P 5.37x38 Structure Structure
TM5 204 Y 5.38x39 Structure Structure
TM5 205 V 5.39x40 Structure Structure
TM5 206 L 5.40x41 Structure Structure
TM5 207 L 5.41x42 Structure Structure
TM5 208 S 5.42x43 Structure Structure
TM5 209 S 5.43x44 Structure Structure
TM5 210 S 5.44x45 Structure Structure
TM5 211 V 5.45x46 Structure Structure
TM5 212 S 5.46x461 Structure Structure
TM5 213 F 5.47x47 Structure Structure
TM5 214 Y 5.48x48 Structure Structure
TM5 215 L 5.49x49 Structure Structure
TM5 216 P 5.50x50 Structure Structure
TM5 217 L 5.51x51 Structure Structure
TM5 218 L 5.52x52 Structure Structure
TM5 219 V 5.53x53 Structure Structure
TM5 220 M 5.54x54 Structure Structure
TM5 221 L 5.55x55 Structure Structure
TM5 222 F 5.56x56 Structure Structure
TM5 223 V 5.57x57 Structure Structure
TM5 224 Y 5.58x58 Structure Structure
TM5 225 A 5.59x59 Structure Structure
TM5 226 R 5.60x60 Structure Structure
TM5 227 V 5.61x61 Structure Structure
TM5 228 F 5.62x62 Structure Structure
TM5 229 V 5.63x63 Structure Structure
TM5 230 V 5.64x64 Structure Structure
TM5 231 A 5.65x65 Structure Structure
TM5 232 T 5.66x66 Structure Structure
TM5 233 R 5.67x67 Structure Structure
TM5 234 Q 5.68x68 Structure Structure
TM5 235 L 5.69x69 Structure Structure
TM5 236 R 5.70x70 Structure Structure
TM5 237 L 5.71x71 Structure Structure
TM5 238 L 5.72x72 Structure Structure
TM5 239 R 5.73x73 Structure Structure
TM5 240 G 5.74x74 Structure Structure
TM5 241 E 5.75x75 Structure Structure
TM5 242 L 5.76x76 Structure Structure
ICL3 243 G - Structure Structure
ICL3 244 R - Structure Structure
ICL3 245 F - Structure Structure
ICL3 246 P - AF2 AF2
ICL3 247 P - AF2 AF2
ICL3 248 E - AF2 AF2
ICL3 249 E - AF2 AF2
ICL3 274 A - AF2 AF2
ICL3 275 C - AF2 AF2
ICL3 276 G - AF2 AF2
ICL3 277 R - AF2 AF2
ICL3 278 R - AF2 AF2
ICL3 279 P - AF2 AF2
ICL3 280 A - AF2 AF2
TM6 281 R 6.24x24 AF2 AF2
TM6 282 L 6.25x25 AF2 AF2
TM6 283 L 6.26x26 AF2 AF2
TM6 284 P 6.27x27 AF2 AF2
TM6 285 L 6.28x28 AF2 AF2
TM6 286 R 6.29x29 AF2 AF2
TM6 287 E 6.30x30 AF2 AF2
TM6 288 H 6.31x31 AF2 AF2
TM6 289 R 6.32x32 Structure Structure
TM6 290 A 6.33x33 Structure Structure
TM6 291 L 6.34x34 Structure Structure
TM6 292 C 6.35x35 Structure Structure
TM6 293 T 6.36x36 Structure Structure
TM6 294 L 6.37x37 Structure Structure
TM6 295 G 6.38x38 Structure Structure
TM6 296 L 6.39x39 Structure Structure
TM6 297 I 6.40x40 Structure Structure
TM6 298 M 6.41x41 Structure Structure
TM6 299 G 6.42x42 Structure Structure
TM6 300 T 6.43x43 Structure Structure
TM6 301 F 6.44x44 Structure Structure
TM6 302 T 6.45x45 Structure Structure
TM6 303 L 6.46x46 Structure Structure
TM6 304 C 6.47x47 Structure Structure
TM6 305 W 6.48x48 Structure Structure
TM6 306 L 6.49x49 Structure Structure
TM6 307 P 6.50x50 Structure Structure
TM6 308 F 6.51x51 Structure Structure
TM6 309 F 6.52x52 Structure Structure
TM6 310 L 6.53x53 Structure Structure
TM6 311 A 6.54x54 Structure Structure
TM6 312 N 6.55x55 Structure Structure
TM6 313 V 6.56x56 Structure Structure
TM6 314 L 6.57x57 Structure Structure
TM6 315 R 6.58x58 Structure Structure
TM6 316 A 6.59x59 Structure Structure
TM6 317 L 6.60x60 Structure Structure
TM6 318 G 6.61x61 Structure Structure
TM6 319 G 6.62x62 Structure Structure
ECL3 320 P - Structure Structure
ECL3 321 S - Structure Structure
ECL3 322 L - Structure Structure
ECL3 323 V - Structure Structure
TM7 324 P 7.31x30 Structure Structure
TM7 325 G 7.32x31 Structure Structure
TM7 326 P 7.33x32 Structure Structure
TM7 327 A 7.34x33 Structure Structure
TM7 328 F 7.35x34 Structure Structure
TM7 329 L 7.36x35 Structure Structure
TM7 330 A 7.37x36 Structure Structure
TM7 331 L 7.38x37 Structure Structure
TM7 332 N 7.39x38 Structure Structure
TM7 333 W 7.40x39 Structure Structure
TM7 334 L 7.41x40 Structure Structure
TM7 335 G 7.42x41 Structure Structure
TM7 336 Y 7.43x42 Structure Structure
TM7 337 A 7.44x43 Structure Structure
TM7 338 N 7.45x45 Structure Structure
TM7 339 S 7.46x46 Structure Structure
TM7 340 A 7.47x47 Structure Structure
TM7 341 F 7.48x48 Structure Structure
TM7 342 N 7.49x49 Structure Structure
TM7 343 P 7.50x50 Structure Structure
TM7 344 L 7.51x51 Structure Structure
TM7 345 I 7.52x52 Structure Structure
TM7 346 Y 7.53x53 Structure Structure
TM7 347 C 7.54x54 Structure Structure
TM7 348 R 7.55x55 Structure Structure
H8 349 S 8.47x47 Structure Structure
H8 350 P 8.48x48 Structure Structure
H8 351 D 8.49x49 Structure Structure
H8 352 F 8.50x50 Structure Structure
H8 353 R 8.51x51 Structure Structure
H8 354 S 8.52x52 Structure Structure
H8 355 A 8.53x53 Structure Structure
H8 356 F 8.54x54 Structure Structure
H8 357 R 8.55x55 Structure Structure
H8 358 R 8.56x56 Structure Structure
H8 359 L 8.57x57 Structure Structure
H8 360 L 8.58x58 Structure Structure
H8 361 C 8.59x59 Structure Structure
H8 362 R 8.60x60 Structure AF2
C-term 363 C - AF2 AF2
C-term 364 G - AF2 AF2
C-term 365 R - AF2 AF2
C-term 366 R - AF2 AF2
C-term 367 L - AF2 AF2
C-term 368 P - AF2 AF2
C-term 369 P - AF2 AF2
C-term 370 E - AF2 AF2
C-term 371 P - AF2 AF2
C-term 372 C - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 138 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 142 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 A 231 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 235 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 235 5x69 G.H5 L 394 G.H5.26
Polar TM2 T 72 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 72 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 Q 234 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 234 5x68 G.H5 L 388 G.H5.20
Polar TM3 V 139 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 139 3x54 G.H5 Q 384 G.H5.16
Polar ICL3 R 277 - G.H3 N 278 G.H3.14
Hydrophobic ICL2 P 142 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 R 144 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL3 F 245 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 F 245 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 143 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 A 231 5x65 G.H5 L 388 G.H5.20
Polar TM5 Q 234 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 234 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM6 R 289 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 289 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 238 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 238 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 H 288 6x31 G.H5 L 394 G.H5.26
Polar ICL3 R 277 - G.h4s6 S 352 G.h4s6.08
Van-der-waals ICL3 R 277 - G.h4s6 S 352 G.h4s6.08
Hydrophobic TM6 L 294 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL3 F 245 - G.H4 D 343 G.H4.13
Hydrophobic TM6 R 286 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 286 6x29 G.H5 L 394 G.H5.26
Ionic ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Ionic ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Polar TM3 T 140 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 143 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 143 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 142 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 230 5x64 G.H5 Q 384 G.H5.16
Polar TM6 R 286 6x29 G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL3 F 245 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 F 245 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 Y 145 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 143 34x51 G.H5 R 380 G.H5.12
Polar TM6 A 290 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 290 6x33 G.H5 L 393 G.H5.25
Ionic TM5 E 241 5x75 G.H5 R 385 G.H5.17
Polar TM5 E 241 5x75 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 241 5x75 G.H5 R 385 G.H5.17
Hydrophobic TM5 V 227 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 143 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 T 293 6x36 G.H5 L 393 G.H5.25
Ionic TM7 R 348 7x55 G.H5 E 392 G.H5.24
Polar TM3 A 138 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 138 3x53 G.H5 H 387 G.H5.19
Aromatic TM3 R 135 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 139 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 142 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 143 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 143 34x51 G.H5 F 376 G.H5.08
Polar TM5 Q 234 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 234 5x68 G.H5 D 381 G.H5.13
Polar TM5 Q 234 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 234 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL3 F 245 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 F 245 - G.H4 L 346 G.H4.16
Hydrophobic TM6 E 287 6x30 G.H5 L 394 G.H5.26
Polar TM6 T 293 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 293 6x36 G.H5 E 392 G.H5.24