TAAR9 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IW7

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-023-06106-4

PUBLICATION DATE

May 31, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

14 interactions (Click to see)

LIGANDS

2-Phenylethanaminium - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Y 140 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 140 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 137 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 137 - G.H5 I 383 G.H5.15
Polar TM5 Q 227 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 227 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 227 5x68 G.H5 Q 384 G.H5.16
Polar TM6 A 256 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 256 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 256 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 259 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 259 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 138 - G.S3 F 219 G.S3.03
Aromatic TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 Y 391 G.H5.23
Aromatic ICL2 Y 140 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 140 - G.H5 H 387 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 220 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 220 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 223 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 227 5x68 G.H5 L 388 G.H5.20
Ionic TM3 D 136 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM6 K 255 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 255 6x32 G.H5 L 394 G.H5.26
Polar TM3 A 133 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 138 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 138 - G.H5 I 383 G.H5.15
Polar ICL2 L 138 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 138 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 138 - G.S1 H 41 G.S1.02
Polar TM5 Q 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 227 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 227 5x68 G.H5 D 381 G.H5.13
Polar ICL2 P 141 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 141 - G.hns1 R 38 G.hns1.02
Polar ICL2 T 142 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 L 138 - G.H5 C 379 G.H5.11
Hydrophobic TM5 Q 227 5x68 G.H5 L 394 G.H5.26
Polar TM3 V 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 134 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 137 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 142 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 142 - G.hns1 A 39 G.hns1.03
Van-der-waals TM5 I 231 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM6 L 260 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 134 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 388 G.H5.20
Polar TM6 T 259 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 259 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 137 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 137 - G.H5 R 380 G.H5.12
Hydrophobic TM4 T 145 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 145 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM6 K 255 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 255 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL4 Y 315 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 137 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 137 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM5 Q 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 227 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 224 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 V 134 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 138 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 376 G.H5.08
Hydrophobic ICL4 F 314 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 F 314 - G.H5 E 392 G.H5.24
Hydrophobic TM5 A 228 5x69 G.H5 L 394 G.H5.26
Polar TM3 T 135 3x55 G.H5 R 380 G.H5.12
Hydrophobic H8 P 316 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 P 316 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 138 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 138 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 138 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 138 - G.S3 V 217 G.S3.01
Polar ICL2 F 144 - G.hns1 R 38 G.hns1.02