Refined structure (7YU3) of Gi1 - LPA1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 222 from structure (62.7%), 132 from model (37.3%)
Residue sidechains - 219 from structure (61.9%), 135 from model (38.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure AF2
G.HN 9 D G.HN.33 Structure AF2
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 290 from structure (86.1%), 47 from model (13.9%)
Residue sidechains - 265 from structure (78.6%), 72 from model (21.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 A - AF2 AF2
N-term 4 I - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 I - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 I - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 Q - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 Q - AF2 AF2
N-term 16 F - AF2 AF2
N-term 17 T - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 M - AF2 AF2
N-term 20 N - AF2 AF2
N-term 21 E - AF2 AF2
N-term 22 P - AF2 AF2
N-term 23 Q - Structure Structure
N-term 24 C - Structure Structure
N-term 25 F - Structure AF2
N-term 26 Y - Structure Structure
N-term 27 N - Structure AF2
N-term 28 E - Structure AF2
N-term 29 S - Structure Structure
N-term 30 I - Structure Structure
N-term 31 A - Structure Structure
N-term 32 F - Structure Structure
N-term 33 F - Structure Structure
N-term 34 Y - Structure Structure
N-term 35 N - Structure Structure
N-term 36 R - Structure Structure
N-term 37 S - Structure Structure
N-term 38 G - Structure Structure
N-term 39 K - Structure Structure
N-term 40 H - Structure Structure
N-term 41 L - Structure Structure
N-term 42 A - Structure Structure
N-term 43 T - Structure Structure
N-term 44 E - Structure AF2
N-term 45 W - Structure Structure
N-term 46 N - Structure Structure
TM1 47 T 1.30x30 Structure AF2
TM1 48 V 1.31x31 Structure Structure
TM1 49 S 1.32x32 Structure Structure
TM1 50 K 1.33x33 Structure AF2
TM1 51 L 1.34x34 Structure Structure
TM1 52 V 1.35x35 Structure Structure
TM1 53 M 1.36x36 Structure Structure
TM1 54 G 1.37x37 Structure Structure
TM1 55 L 1.38x38 Structure Structure
TM1 56 G 1.39x39 Structure Structure
TM1 57 I 1.40x40 Structure Structure
TM1 58 T 1.41x41 Structure Structure
TM1 59 V 1.42x42 Structure Structure
TM1 60 C 1.43x43 Structure Structure
TM1 61 I 1.44x44 Structure AF2
TM1 62 F 1.45x45 Structure Structure
TM1 63 I 1.46x46 Structure Structure
TM1 64 M 1.47x47 Structure Structure
TM1 65 L 1.48x48 Structure AF2
TM1 66 A 1.49x49 Structure Structure
TM1 67 N 1.50x50 Structure Structure
TM1 68 L 1.51x51 Structure AF2
TM1 69 L 1.52x52 Structure Structure
TM1 70 V 1.53x53 Structure Structure
TM1 71 M 1.54x54 Structure Structure
TM1 72 V 1.55x55 Structure AF2
TM1 73 A 1.56x56 Structure Structure
TM1 74 I 1.57x57 Structure AF2
TM1 75 Y 1.58x58 Structure Structure
TM1 76 V 1.59x59 Structure Structure
TM1 77 N 1.60x60 Structure Structure
ICL1 78 R 12.48x48 Structure AF2
ICL1 79 R 12.49x49 Structure AF2
ICL1 80 F 12.50x50 Structure Structure
ICL1 81 H 12.51x51 Structure AF2
TM2 82 F 2.37x37 Structure Structure
TM2 83 P 2.38x38 Structure Structure
TM2 84 I 2.39x39 Structure Structure
TM2 85 Y 2.40x40 Structure Structure
TM2 86 Y 2.41x41 Structure Structure
TM2 87 L 2.42x42 Structure Structure
TM2 88 M 2.43x43 Structure Structure
TM2 89 A 2.44x44 Structure Structure
TM2 90 N 2.45x45 Structure Structure
TM2 91 L 2.46x46 Structure Structure
TM2 92 A 2.47x47 Structure Structure
TM2 93 A 2.48x48 Structure Structure
TM2 94 A 2.49x49 Structure Structure
TM2 95 D 2.50x50 Structure Structure
TM2 96 F 2.51x51 Structure Structure
TM2 97 F 2.52x52 Structure Structure
TM2 98 A 2.53x53 Structure Structure
TM2 99 G 2.54x54 Structure Structure
TM2 100 L 2.55x55 Structure Structure
TM2 101 A 2.56x56 Structure Structure
TM2 102 Y 2.57x57 Structure Structure
TM2 103 F 2.58x58 Structure Structure
TM2 104 Y 2.59x59 Structure Structure
TM2 105 L 2.60x60 Structure Structure
TM2 106 M 2.61x61 Structure Structure
TM2 107 F 2.62x62 Structure Structure
TM2 108 N 2.63x63 Structure Structure
ECL1 109 T - Structure Structure
ECL1 110 G 23.47x47 Structure Structure
ECL1 111 P 23.48x48 Structure Structure
ECL1 112 N 23.49x49 Structure Structure
ECL1 113 T 23.50x50 Structure Structure
ECL1 114 R 23.51x501 Structure Structure
ECL1 115 R 23.52x51 Structure AF2
ECL1 116 L 23.53x52 Structure Structure
TM3 117 T 3.21x21 Structure Structure
TM3 118 V 3.22x22 Structure Structure
TM3 119 S 3.23x23 Structure Structure
TM3 120 T 3.24x24 Structure Structure
TM3 121 W 3.25x25 Structure Structure
TM3 122 L 3.26x26 Structure Structure
TM3 123 L 3.27x27 Structure Structure
TM3 124 R 3.28x28 Structure Structure
TM3 125 Q 3.29x29 Structure Structure
TM3 126 G 3.30x30 Structure Structure
TM3 127 L 3.31x31 Structure Structure
TM3 128 I 3.32x32 Structure Structure
TM3 129 D 3.33x33 Structure Structure
TM3 130 T 3.34x34 Structure Structure
TM3 131 S 3.35x35 Structure Structure
TM3 132 L 3.36x36 Structure Structure
TM3 133 T 3.37x37 Structure Structure
TM3 134 A 3.38x38 Structure Structure
TM3 135 S 3.39x39 Structure Structure
TM3 136 V 3.40x40 Structure Structure
TM3 137 A 3.41x41 Structure Structure
TM3 138 N 3.42x42 Structure Structure
TM3 139 L 3.43x43 Structure Structure
TM3 140 L 3.44x44 Structure Structure
TM3 141 A 3.45x45 Structure Structure
TM3 142 I 3.46x46 Structure Structure
TM3 143 A 3.47x47 Structure Structure
TM3 144 I 3.48x48 Structure Structure
TM3 145 E 3.49x49 Structure Structure
TM3 146 R 3.50x50 Structure Structure
TM3 147 H 3.51x51 Structure Structure
TM3 148 I 3.52x52 Structure Structure
TM3 149 T 3.53x53 Structure Structure
TM3 150 V 3.54x54 Structure Structure
TM3 151 F 3.55x55 Structure Structure
TM3 152 R 3.56x56 Structure Structure
ICL2 153 M 34.50x50 Structure Structure
ICL2 154 Q 34.51x51 Structure Structure
ICL2 155 L 34.52x52 Structure Structure
ICL2 156 H 34.53x53 Structure Structure
ICL2 157 T 34.54x54 Structure Structure
ICL2 158 R 34.55x55 Structure AF2
ICL2 159 M 34.56x56 Structure AF2
TM4 160 S 4.38x38 Structure Structure
TM4 161 N 4.39x39 Structure Structure
TM4 162 R 4.40x40 Structure AF2
TM4 163 R 4.41x41 Structure Structure
TM4 164 V 4.42x42 Structure Structure
TM4 165 V 4.43x43 Structure Structure
TM4 166 V 4.44x44 Structure Structure
TM4 167 V 4.45x45 Structure Structure
TM4 168 I 4.46x46 Structure Structure
TM4 169 V 4.47x47 Structure Structure
TM4 170 V 4.48x48 Structure Structure
TM4 171 I 4.49x49 Structure Structure
TM4 172 W 4.50x50 Structure Structure
TM4 173 T 4.51x51 Structure AF2
TM4 174 M 4.52x52 Structure Structure
TM4 175 A 4.53x53 Structure Structure
TM4 176 I 4.54x54 Structure Structure
TM4 177 V 4.55x55 Structure Structure
TM4 178 M 4.56x56 Structure Structure
TM4 179 G 4.57x57 Structure Structure
TM4 180 A 4.58x58 Structure Structure
TM4 181 I 4.59x59 Structure Structure
TM4 182 P 4.60x60 Structure Structure
TM4 183 S 4.61x61 Structure Structure
TM4 184 V 4.62x62 Structure Structure
TM4 185 G 4.63x63 Structure Structure
ECL2 186 W - Structure Structure
ECL2 187 N - Structure Structure
ECL2 188 C - Structure Structure
ECL2 189 I - Structure Structure
ECL2 190 C - Structure Structure
ECL2 191 D - Structure Structure
ECL2 192 I - Structure Structure
ECL2 193 E - Structure AF2
ECL2 194 N - Structure Structure
ECL2 195 C - Structure Structure
ECL2 196 S - Structure Structure
ECL2 197 N - Structure Structure
ECL2 198 M - Structure Structure
ECL2 199 A - Structure Structure
ECL2 200 P - Structure Structure
ECL2 201 L - Structure Structure
ECL2 202 Y - Structure Structure
TM5 203 S 5.36x36 Structure Structure
TM5 204 D 5.37x37 Structure Structure
TM5 205 S 5.38x38 Structure Structure
TM5 206 Y 5.39x39 Structure Structure
TM5 207 L 5.40x40 Structure Structure
TM5 208 V 5.41x41 Structure Structure
TM5 209 F 5.42x42 Structure Structure
TM5 210 W 5.43x43 Structure Structure
TM5 211 A 5.44x44 Structure Structure
TM5 212 I 5.45x45 Structure Structure
TM5 213 F 5.46x46 Structure Structure
TM5 214 N 5.47x47 Structure Structure
TM5 215 L 5.48x48 Structure Structure
TM5 216 V 5.49x49 Structure Structure
TM5 217 T 5.50x50 Structure Structure
TM5 218 F 5.51x51 Structure Structure
TM5 219 V 5.52x52 Structure Structure
TM5 220 V 5.53x53 Structure Structure
TM5 221 M 5.54x54 Structure Structure
TM5 222 V 5.55x55 Structure Structure
TM5 223 V 5.56x56 Structure Structure
TM5 224 L 5.57x57 Structure Structure
TM5 225 Y 5.58x58 Structure Structure
TM5 226 A 5.59x59 Structure Structure
TM5 227 H 5.60x60 Structure Structure
TM5 228 I 5.61x61 Structure Structure
TM5 229 F 5.62x62 Structure Structure
TM5 230 G 5.63x63 Structure Structure
TM5 231 Y 5.64x64 Structure Structure
TM5 232 V 5.65x65 Structure Structure
TM5 233 R 5.66x66 Structure Structure
TM5 234 Q 5.67x67 Structure Structure
TM5 235 R 5.68x68 Structure Structure
TM5 236 T 5.69x69 Structure Structure
TM5 237 M 5.70x70 Structure AF2
TM5 238 R 5.71x71 Structure Structure
TM5 239 M 5.72x72 Structure Structure
TM5 240 S 5.73x73 AF2 AF2
ICL3 241 R - AF2 AF2
ICL3 242 H - AF2 AF2
ICL3 243 S - AF2 AF2
ICL3 244 S - AF2 AF2
TM6 245 G 6.22x22 AF2 AF2
TM6 246 P 6.23x23 AF2 AF2
TM6 247 R 6.24x24 AF2 AF2
TM6 248 R 6.25x25 AF2 AF2
TM6 249 N 6.26x26 AF2 AF2
TM6 250 R 6.27x27 AF2 AF2
TM6 251 D 6.28x28 Structure Structure
TM6 252 T 6.29x29 Structure Structure
TM6 253 M 6.30x30 Structure Structure
TM6 254 M 6.31x31 Structure AF2
TM6 255 S 6.32x32 Structure Structure
TM6 256 L 6.33x33 Structure Structure
TM6 257 L 6.34x34 Structure Structure
TM6 258 K 6.35x35 Structure Structure
TM6 259 T 6.36x36 Structure Structure
TM6 260 V 6.37x37 Structure Structure
TM6 261 V 6.38x38 Structure Structure
TM6 262 I 6.39x39 Structure Structure
TM6 263 V 6.40x40 Structure Structure
TM6 264 L 6.41x41 Structure Structure
TM6 265 G 6.42x42 Structure Structure
TM6 266 A 6.43x43 Structure Structure
TM6 267 F 6.44x44 Structure Structure
TM6 268 I 6.45x45 Structure Structure
TM6 269 I 6.46x46 Structure Structure
TM6 270 C 6.47x47 Structure Structure
TM6 271 W 6.48x48 Structure Structure
TM6 272 T 6.49x49 Structure Structure
TM6 273 P 6.50x50 Structure Structure
TM6 274 G 6.51x51 Structure Structure
TM6 275 L 6.52x52 Structure Structure
TM6 276 V 6.53x53 Structure Structure
TM6 277 L 6.54x54 Structure Structure
TM6 278 L 6.55x55 Structure Structure
TM6 279 L 6.56x56 Structure Structure
TM6 280 L 6.57x57 Structure Structure
TM6 281 D 6.58x58 Structure Structure
TM6 282 V 6.59x59 Structure Structure
TM6 283 C 6.60x60 Structure Structure
TM6 284 C 6.61x61 Structure Structure
ECL3 285 P - Structure Structure
ECL3 286 Q - Structure AF2
ECL3 287 C - Structure Structure
TM7 288 D 7.30x29 Structure Structure
TM7 289 V 7.31x30 Structure Structure
TM7 290 L 7.32x31 Structure Structure
TM7 291 A 7.33x32 Structure Structure
TM7 292 Y 7.34x33 Structure Structure
TM7 293 E 7.35x34 Structure Structure
TM7 294 K 7.36x35 Structure Structure
TM7 295 F 7.37x36 Structure Structure
TM7 296 F 7.38x37 Structure Structure
TM7 297 L 7.39x38 Structure Structure
TM7 298 L 7.40x39 Structure Structure
TM7 299 L 7.41x40 Structure Structure
TM7 300 A 7.42x41 Structure Structure
TM7 301 E 7.43x42 Structure Structure
TM7 302 F 7.44x43 Structure Structure
TM7 303 N 7.45x45 Structure Structure
TM7 304 S 7.46x46 Structure Structure
TM7 305 A 7.47x47 Structure Structure
TM7 306 M 7.48x48 Structure Structure
TM7 307 N 7.49x49 Structure Structure
TM7 308 P 7.50x50 Structure Structure
TM7 309 I 7.51x51 Structure Structure
TM7 310 I 7.52x52 Structure Structure
TM7 311 Y 7.53x53 Structure Structure
TM7 312 S 7.54x54 Structure Structure
TM7 313 Y 7.55x55 Structure Structure
TM7 314 R 7.56x56 Structure Structure
H8 315 D 8.47x47 Structure Structure
H8 316 K 8.48x48 Structure AF2
H8 317 E 8.49x49 Structure AF2
H8 318 M 8.50x50 Structure Structure
H8 319 S 8.51x51 Structure Structure
H8 320 A 8.52x52 Structure Structure
H8 321 T 8.53x53 Structure Structure
H8 322 F 8.54x54 Structure Structure
H8 323 R 8.55x55 Structure Structure
H8 324 Q 8.56x56 AF2 AF2
H8 325 I 8.57x57 AF2 AF2
H8 326 L 8.58x58 AF2 AF2
H8 327 C 8.59x59 AF2 AF2
C-term 328 C - AF2 AF2
C-term 329 Q - AF2 AF2
C-term 330 R - AF2 AF2
C-term 331 S - AF2 AF2
C-term 332 E - AF2 AF2
C-term 333 N - AF2 AF2
C-term 334 P - AF2 AF2
C-term 335 T - AF2 AF2
C-term 336 G - AF2 AF2
C-term 337 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM5 R 235 5x68 G.H5 F 336 G.H5.08
Hydrophobic TM6 R 248 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM5 Y 231 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 Y 231 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM2 I 84 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 T 149 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 155 34x52 G.H5 N 346 G.H5.18
Van-der-waals ICL2 L 155 34x52 G.H5 N 346 G.H5.18
Polar ICL3 S 244 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 S 244 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 S 244 - G.H4 E 308 G.H4.16
Hydrophobic TM3 R 146 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 150 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 153 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 153 34x50 G.H5 I 343 G.H5.15
Polar TM3 R 152 3x56 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 152 3x56 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 152 3x56 G.H5 N 347 G.H5.19
Ionic TM5 R 238 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 238 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 238 5x71 G.H5 D 337 G.H5.09
Hydrophobic ICL3 H 242 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 H 242 - G.H5 F 334 G.H5.06
Ionic TM3 R 152 3x56 G.H5 D 350 G.H5.22
Polar TM3 R 152 3x56 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 152 3x56 G.H5 D 350 G.H5.22
Hydrophobic TM5 M 239 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 M 239 5x72 G.S6 Y 320 G.S6.02
Ionic TM6 R 248 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 248 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 248 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 248 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 155 34x52 G.H5 I 343 G.H5.15
Van-der-waals TM7 R 314 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 232 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 M 239 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM2 I 84 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 I 84 2x39 G.H5 D 350 G.H5.22
Polar TM3 V 150 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 150 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 150 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 153 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 L 256 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 M 239 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 M 239 5x72 G.H5 F 334 G.H5.06
Hydrophobic ICL2 Q 154 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 154 34x51 G.hns1 R 32 G.hns1.03
Polar TM6 R 248 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 M 153 34x50 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 153 34x50 G.S3 L 194 G.S3.01
Hydrophobic TM5 T 236 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 T 236 5x69 G.H5 D 341 G.H5.13
Hydrophobic ICL3 S 243 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 M 239 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM5 V 232 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 156 34x53 G.h2s4 G 217 G.h2s4.03
Polar TM6 R 248 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 L 256 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 256 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 239 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 239 5x72 G.H5 D 337 G.H5.09
Polar TM6 R 248 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 T 252 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM7 R 314 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM7 R 314 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 228 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 259 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 259 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 252 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 252 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 155 34x52 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM5 Y 225 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM3 T 149 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 T 149 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 V 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 348 G.H5.20
Polar TM3 T 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 T 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 T 149 3x53 G.H5 N 347 G.H5.19