TA1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WC8

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.CELL.2023.10.014

PUBLICATION DATE

Dec. 27, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

26 interactions (Click to see)

LIGANDS

CHEMBL476516 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

octopamine, tyramine, β-phenylethylamine, 3-iodothyronamine, dopamine, CHEMBL1160703, (+)-Octopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 252 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM3 A 124 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM5 I 224 5x72 G.h4s6 Y 325 G.h4s6.20
Aromatic ICL2 Y 131 - G.H5 H 354 G.H5.19
Hydrophobic ICL2 Y 131 - G.H5 H 354 G.H5.19
Van-der-waals ICL2 Y 131 - G.H5 H 354 G.H5.19
Hydrophobic TM5 Q 220 5x68 G.H5 L 355 G.H5.20
Hydrophobic ICL2 L 129 - G.H5 R 347 G.H5.12
Hydrophobic ICL2 P 128 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 128 - G.H5 I 350 G.H5.15
Polar TM6 A 249 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 360 G.H5.25
Polar TM3 V 125 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM3 V 125 3x54 G.H5 Q 351 G.H5.16
Van-der-waals TM3 V 125 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM6 K 248 6x32 G.H5 L 361 G.H5.26
Polar TM6 T 252 6x36 G.H5 E 359 G.H5.24
Van-der-waals TM6 T 252 6x36 G.H5 E 359 G.H5.24
Hydrophobic ICL2 P 128 - G.H5 H 354 G.H5.19
Aromatic TM3 R 121 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM6 K 248 6x32 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 129 - G.S3 V 194 G.S3.01
Hydrophobic TM5 Q 220 5x68 G.H5 L 361 G.H5.26
Hydrophobic ICL2 L 129 - G.H5 C 346 G.H5.11
Polar TM5 Q 220 5x68 G.H5 R 352 G.H5.17
Hydrophobic TM5 Q 220 5x68 G.H5 R 352 G.H5.17
Van-der-waals TM5 Q 220 5x68 G.H5 R 352 G.H5.17
Hydrophobic H8 Y 308 8x47 G.H5 Y 358 G.H5.23
Van-der-waals H8 Y 308 8x47 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 129 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 129 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 L 129 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 343 G.H5.08
Hydrophobic TM3 V 125 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM5 A 217 5x65 G.H5 L 360 G.H5.25
Van-der-waals TM5 A 217 5x65 G.H5 L 360 G.H5.25
Hydrophobic TM5 I 224 5x72 G.H5 R 352 G.H5.17
Van-der-waals TM5 I 224 5x72 G.H5 R 352 G.H5.17
Hydrophobic ICL2 P 128 - G.H5 R 347 G.H5.12
Polar TM5 Q 220 5x68 G.H5 Q 351 G.H5.16
Van-der-waals TM5 Q 220 5x68 G.H5 Q 351 G.H5.16
Hydrophobic TM6 L 253 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 360 G.H5.25
Polar H8 W 310 8x49 G.H5 Q 357 G.H5.22
Van-der-waals H8 W 310 8x49 G.H5 Q 357 G.H5.22
Polar TM3 A 124 3x53 G.H5 H 354 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 354 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 354 G.H5.19
Hydrophobic TM5 I 224 5x72 G.H5 L 361 G.H5.26
Van-der-waals TM5 I 224 5x72 G.H5 L 361 G.H5.26
Polar ICL2 L 129 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 L 129 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 129 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 L 129 - G.S3 F 196 G.S3.03
Hydrophobic TM6 K 248 6x32 G.H5 E 359 G.H5.24
Van-der-waals TM6 K 248 6x32 G.H5 E 359 G.H5.24
Hydrophobic H8 P 309 8x48 G.H5 E 359 G.H5.24
Van-der-waals H8 P 309 8x48 G.H5 E 359 G.H5.24
Polar ICL2 Y 131 - G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 128 - G.H5 Q 351 G.H5.16
Van-der-waals ICL2 P 128 - G.H5 Q 351 G.H5.16
Hydrophobic TM3 V 125 3x54 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 R 130 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 R 130 - G.S3 V 194 G.S3.01
Polar ICL2 K 132 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 K 132 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 K 132 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 I 213 5x61 G.H5 L 360 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM4 N 136 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 N 136 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 A 217 5x65 G.H5 L 355 G.H5.20
Hydrophobic ICL2 A 133 - G.hns1 A 32 G.hns1.03
Hydrophobic H8 Y 308 8x47 G.H5 E 359 G.H5.24
Van-der-waals H8 Y 308 8x47 G.H5 E 359 G.H5.24
Polar ICL2 R 130 - G.s2s3 D 192 G.s2s3.01
Van-der-waals ICL2 R 130 - G.s2s3 D 192 G.s2s3.01
Hydrophobic TM3 V 125 3x54 G.H5 H 354 G.H5.19
Van-der-waals TM3 V 125 3x54 G.H5 H 354 G.H5.19
Hydrophobic TM5 I 216 5x64 G.H5 Q 351 G.H5.16