TA1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WC6

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.CELL.2023.10.014

PUBLICATION DATE

Dec. 27, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

15 interactions (Click to see)

LIGANDS

2-Phenylethanaminium - Agonist pubchem

PHYSIOLOGICAL LIGANDS

3-iodothyronamine, β-phenylethylamine, tyramine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 216 5x65 G.H5 L 355 G.H5.20
Hydrophobic ICL2 P 127 - G.H5 Q 351 G.H5.16
Van-der-waals ICL2 P 127 - G.H5 Q 351 G.H5.16
Hydrophobic TM5 Q 219 5x68 G.H5 L 355 G.H5.20
Polar TM5 Q 219 5x68 G.H5 Q 351 G.H5.16
Polar TM5 S 222 5x71 G.H5 R 352 G.H5.17
Aromatic TM3 R 120 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 127 - G.H5 R 347 G.H5.12
Hydrophobic TM5 I 223 5x72 G.h4s6 Y 325 G.h4s6.20
Van-der-waals TM5 I 223 5x72 G.h4s6 Y 325 G.h4s6.20
Hydrophobic TM6 T 249 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM5 I 212 5x61 G.H5 L 360 G.H5.25
Van-der-waals TM5 I 212 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM5 I 223 5x72 G.H5 R 352 G.H5.17
Van-der-waals TM5 I 223 5x72 G.H5 R 352 G.H5.17
Polar ICL2 L 128 - G.S1 H 34 G.S1.02
Polar TM3 V 124 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM3 V 124 3x54 G.H5 Q 351 G.H5.16
Van-der-waals TM3 V 124 3x54 G.H5 Q 351 G.H5.16
Hydrophobic ICL2 P 127 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 127 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 L 128 - G.H5 C 346 G.H5.11
Hydrophobic TM3 V 124 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 355 G.H5.20
Hydrophobic ICL2 P 127 - G.H5 H 354 G.H5.19
Hydrophobic TM5 Q 219 5x68 G.H5 L 361 G.H5.26
Hydrophobic TM6 A 246 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 A 246 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM5 A 216 5x65 G.H5 L 360 G.H5.25
Van-der-waals TM5 A 216 5x65 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 128 - G.H5 I 350 G.H5.15
Polar TM3 C 125 3x55 G.H5 Q 351 G.H5.16
Hydrophobic ICL2 L 128 - G.S3 F 196 G.S3.03
Hydrophobic ICL2 R 129 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 R 129 - G.S3 V 194 G.S3.01
Hydrophobic ICL2 L 128 - G.S3 V 194 G.S3.01
Hydrophobic TM6 L 250 6x37 G.H5 L 360 G.H5.25
Polar TM3 A 123 3x53 G.H5 H 354 G.H5.19
Van-der-waals TM3 A 123 3x53 G.H5 H 354 G.H5.19
Polar TM3 C 125 3x55 G.H5 R 347 G.H5.12
Hydrophobic ICL2 L 128 - G.H5 R 347 G.H5.12
Van-der-waals ICL2 L 128 - G.H5 R 347 G.H5.12
Hydrophobic ICL2 A 132 - G.hns1 A 32 G.hns1.03
Polar TM5 Q 219 5x68 G.H5 R 352 G.H5.17
Hydrophobic TM5 Q 219 5x68 G.H5 R 352 G.H5.17
Van-der-waals TM5 Q 219 5x68 G.H5 R 352 G.H5.17
Polar TM4 N 135 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM3 A 123 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 123 3x53 G.H5 Y 358 G.H5.23
Hydrophobic ICL4 F 304 - G.H5 E 359 G.H5.24
Van-der-waals ICL4 F 304 - G.H5 E 359 G.H5.24
Polar ICL2 K 131 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 K 131 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 K 131 - G.hns1 R 31 G.hns1.02
Polar TM6 K 245 6x32 G.H5 L 361 G.H5.26
Hydrophobic TM6 K 245 6x32 G.H5 L 361 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 L 361 G.H5.26
Hydrophobic TM3 V 124 3x54 G.H5 L 360 G.H5.25
Polar ICL2 Y 130 - G.H5 Y 358 G.H5.23
Hydrophobic H8 Y 305 8x47 G.H5 Y 358 G.H5.23
Van-der-waals H8 Y 305 8x47 G.H5 Y 358 G.H5.23
Hydrophobic TM5 I 215 5x64 G.H5 Q 351 G.H5.16
Aromatic ICL2 Y 130 - G.H5 H 354 G.H5.19
Hydrophobic ICL2 Y 130 - G.H5 H 354 G.H5.19
Van-der-waals ICL2 Y 130 - G.H5 H 354 G.H5.19
Hydrophobic H8 P 306 8x48 G.H5 E 359 G.H5.24
Van-der-waals H8 P 306 8x48 G.H5 E 359 G.H5.24
Ionic TM6 K 245 6x32 G.H5 E 359 G.H5.24
Hydrophobic TM6 K 245 6x32 G.H5 E 359 G.H5.24
Hydrophobic ICL2 L 128 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 128 - G.H5 F 343 G.H5.08
Hydrophobic TM3 V 124 3x54 G.H5 Y 358 G.H5.23