mGlu2 receptor - Gi1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

2

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.6 Å

REFERENCE

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ADX88178 - Agonist pubchem gtoplig chembl_ligand ,

L-glutamic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem ,

JNJ-40411813 - PAM pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

L-glutamic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
A02G.hns1E01G.S1N19D22C23G24L25F26G.H5GproteinQ-R3x53G-R2x36R-H-K12x51A12x52GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.S1G.H5GPCR segments:ICL1TM2ICL2TM3C-term

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null12x5112x5212x532x392x403x493x503x533x54G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.09G.h2s4.05G.S3.01G.S1.02G.S1.01G.hns1.03G.hns1.02Res. Pos.mGlu2 (8JD5)- (8JD5)----------KASGRRIIFKASGRRIIFPLFGCLIDIKNDEVLTAR

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.