ADGRL3 - Gq

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WY5

RESOLUTION

2.8 Å

REFERENCE

10.1016/J.MOLCEL.2022.10.009

PUBLICATION DATE

Oct. 26, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 E 1042 - G.hns1 R 39 G.hns1.03
Hydrophobic TM3 M 1036 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 1036 3x57 G.H5 Y 391 G.H5.23
Polar TM3 M 1036 3x57 G.H5 N 387 G.H5.19
Van-der-waals TM3 M 1036 3x57 G.H5 N 387 G.H5.19
Hydrophobic TM5 H 1117 5x64 G.H5 L 384 G.H5.16
Hydrophobic TM6 L 1150 6x45 G.H5 L 393 G.H5.25
Ionic H8 K 1197 8x49 G.H5 E 390 G.H5.22
Polar H8 K 1197 8x49 G.H5 E 390 G.H5.22
Van-der-waals H8 K 1197 8x49 G.H5 E 390 G.H5.22
Polar ICL2 E 1044 - G.HN Q 35 G.HN.52
Polar TM5 H 1117 5x64 G.H5 Q 385 G.H5.17
Van-der-waals TM5 H 1117 5x64 G.H5 Q 385 G.H5.17
Hydrophobic ICL2 V 1040 - G.H5 K 380 G.H5.12
Hydrophobic ICL2 F 1041 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 1041 - G.H5 I 383 G.H5.15
Hydrophobic TM5 M 1114 5x61 G.H5 V 394 G.H5.26
Van-der-waals TM5 M 1114 5x61 G.H5 V 394 G.H5.26
Hydrophobic TM5 M 1114 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 1114 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 1037 3x58 G.H5 N 387 G.H5.19
Polar TM2 R 977 2x46 G.H5 Y 391 G.H5.23
Aromatic TM2 R 977 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 977 2x46 G.H5 Y 391 G.H5.23
Polar H8 Q 1195 8x47 G.H5 N 392 G.H5.24
Hydrophobic ICL2 V 1040 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 1040 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 1041 - G.H5 K 380 G.H5.12
Hydrophobic TM3 L 1033 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 T 1118 - G.H5 V 394 G.H5.26
Van-der-waals ICL3 T 1118 - G.H5 V 394 G.H5.26
Hydrophobic ICL2 F 1041 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 1041 - G.H5 F 376 G.H5.08
Hydrophobic TM3 L 1037 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 1037 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 1041 - G.S1 L 41 G.S1.02
Ionic TM5 H 1117 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 V 1040 - G.H5 L 384 G.H5.16
Hydrophobic TM3 L 1037 3x58 G.H5 L 384 G.H5.16
Ionic ICL2 E 1042 - G.hns1 R 38 G.hns1.02
Polar ICL2 E 1042 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 1042 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 1041 - G.S3 V 217 G.S3.01