β1-adrenoceptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Meleagris gallopavo

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7S0F

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41594-021-00679-2

PUBLICATION DATE

Nov. 17, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

43 interactions (Click to see)

LIGANDS

LEVISOPRENALINE - Agonist chembl_ligand chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Polar ICL2 Q 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 R 155 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 R 155 4x39 G.HN E 28 G.HN.52
Aromatic ICL2 F 147 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 147 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 147 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 147 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 147 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 Q 237 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 292 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 292 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 Q 237 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 Q 237 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 240 5x71 G.H5 D 341 G.H5.13
Polar TM3 A 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 347 G.H5.19
Polar TM4 T 154 4x38 G.HN E 28 G.HN.52
Polar TM5 Q 237 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 237 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 237 5x68 G.H5 D 341 G.H5.13
Aromatic TM6 R 284 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 284 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 284 6x29 G.H5 F 354 G.H5.26
Polar TM6 T 291 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 291 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 291 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 238 5x69 G.H5 F 354 G.H5.26
Van-der-waals TM5 I 238 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM5 Q 237 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 288 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 288 6x33 G.H5 L 353 G.H5.25
Polar TM6 K 287 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 287 6x32 G.H5 G 352 G.H5.24
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 230 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 230 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 287 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 287 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 F 147 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 147 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Polar ICL2 Q 150 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 143 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 F 147 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 147 34x51 G.H5 I 343 G.H5.15
Polar TM6 R 284 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 284 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 A 234 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 291 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 291 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 146 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 146 34x50 G.H5 I 344 G.H5.16