Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7S0F

SPECIES

Meleagris gallopavo

RESOLUTION

2.960

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-021-00679-2

PUBLICATION DATE

Nov. 17, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LEVISOPRENALINE W117 3.28x28 TM3 hydrophobic
LEVISOPRENALINE D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
LEVISOPRENALINE V122 3.33x33 TM3 polar (hydrogen bond)
LEVISOPRENALINE V125 3.36x36 TM3 polar (hydrogen bond)
LEVISOPRENALINE T126 3.37x37 TM3 polar (hydrogen bond)
LEVISOPRENALINE F201 45.52x52 ECL2 aromatic (face-to-edge)
LEVISOPRENALINE F201 45.52x52 ECL2 polar (hydrogen bond)
LEVISOPRENALINE S211 5.42x43 TM5 polar (hydrogen bond)
LEVISOPRENALINE S211 5.42x43 TM5 polar (hydrogen bond with backbone)
LEVISOPRENALINE S212 5.43x44 TM5 Van der Waals
LEVISOPRENALINE S215 5.46x461 TM5 polar (hydrogen bond)
LEVISOPRENALINE W303 6.48x48 TM6 Van der Waals
LEVISOPRENALINE F306 6.51x51 TM6 aromatic (edge-to-face)
LEVISOPRENALINE F306 6.51x51 TM6 Van der Waals
LEVISOPRENALINE F307 6.52x52 TM6 polar (hydrogen bond)
LEVISOPRENALINE N310 6.55x55 TM6 polar (hydrogen bond)
LEVISOPRENALINE N310 6.55x55 TM6 polar (hydrogen bond)
LEVISOPRENALINE N329 7.39x38 TM7 polar (hydrogen bond)
LEVISOPRENALINE Y333 7.43x42 TM7 polar (hydrogen bond)

Ligands

LEVISOPRENALINE

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Residue Diagrams

V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 V125
3x37 3.37x37 T126
ECL2
45x52 45.52x52 F201
TM5
5x43 5.42x43 S211
5x44 5.43x44 S212
5x461 5.46x461 S215
TM6
6x48 6.48x48 W303
6x51 6.51x51 F306
6x52 6.52x52 F307
6x55 6.55x55 N310
TM7
7x38 7.39x38 N329
7x42 7.43x42 Y333