BLT2 receptor (lt4r2_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Leukotriene receptors BLT2 receptor
GENE
LTB4R2 (BLT2R, BLTR2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Leukotriene B4 receptor 2, LTB4-R 2, LTB4-R2, LTB4 receptor JULF2, Leukotriene B4 receptor BLT2, Seven transmembrane receptor BLTR2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
V
|
C
|
Y
|
R
|
P
|
P
|
G
|
N
|
10 |
TM1 | |||||||||
E
|
T
|
L
|
L
|
S
|
W
|
K
|
T
|
S
|
R
|
20 |
A
|
T
|
G
|
T
|
A
|
F
|
L
|
L
|
L
|
A
|
30 |
A
|
L
|
L
|
G
|
L
|
P
|
G
|
N
|
G
|
F
|
40 |
V
|
V
|
W
|
S
|
L
|
A
|
G
|
W
|
R
|
P
|
50 |
ICL1 | TM2 | ||||||||
A
|
R
|
G
|
R
|
P
|
L
|
A
|
A
|
T
|
L
|
60 |
V
|
L
|
H
|
L
|
A
|
L
|
A
|
D
|
G
|
A
|
70 |
V
|
L
|
L
|
L
|
T
|
P
|
L
|
F
|
V
|
A
|
80 |
ECL1 | |||||||||
F
|
L
|
T
|
R
|
Q
|
A
|
W
|
P
|
L
|
G
|
90 |
TM3 | |||||||||
Q
|
A
|
G
|
C
|
K
|
A
|
V
|
Y
|
Y
|
V
|
100 |
C
|
A
|
L
|
S
|
M
|
Y
|
A
|
S
|
V
|
L
|
110 |
L
|
T
|
G
|
L
|
L
|
S
|
L
|
Q
|
R
|
C
|
120 |
ICL2 | |||||||||
L
|
A
|
V
|
T
|
R
|
P
|
F
|
L
|
A
|
P
|
130 |
TM4 | |||||||||
R
|
L
|
R
|
S
|
P
|
A
|
L
|
A
|
R
|
R
|
140 |
L
|
L
|
L
|
A
|
V
|
W
|
L
|
A
|
A
|
L
|
150 |
L
|
L
|
A
|
V
|
P
|
A
|
A
|
V
|
Y
|
R
|
160 |
ECL2 | |||||||||
H
|
L
|
W
|
R
|
D
|
R
|
V
|
C
|
Q
|
L
|
170 |
TM5 | |||||||||
C
|
H
|
P
|
S
|
P
|
V
|
H
|
A
|
A
|
A
|
180 |
H
|
L
|
S
|
L
|
E
|
T
|
L
|
T
|
A
|
F
|
190 |
V
|
L
|
P
|
F
|
G
|
L
|
M
|
L
|
G
|
C
|
200 |
Y
|
S
|
V
|
T
|
L
|
A
|
R
|
L
|
R
|
G
|
210 |
ICL3 | TM6 | ||||||||
A
|
R
|
W
|
G
|
S
|
G
|
R
|
H
|
G
|
A
|
220 |
R
|
V
|
G
|
R
|
L
|
V
|
S
|
A
|
I
|
V
|
230 |
L
|
A
|
F
|
G
|
L
|
L
|
W
|
A
|
P
|
Y
|
240 |
H
|
A
|
V
|
N
|
L
|
L
|
Q
|
A
|
V
|
A
|
250 |
ECL3 | |||||||||
A
|
L
|
A
|
P
|
P
|
E
|
G
|
A
|
L
|
A
|
260 |
TM7 | |||||||||
K
|
L
|
G
|
G
|
A
|
G
|
Q
|
A
|
A
|
R
|
270 |
A
|
G
|
T
|
T
|
A
|
L
|
A
|
F
|
F
|
S
|
280 |
S
|
S
|
V
|
N
|
P
|
V
|
L
|
Y
|
V
|
F
|
290 |
T
|
A
|
G
|
D
|
L
|
L
|
P
|
R
|
A
|
G
|
300 |
C-term | |||||||||
P
|
R
|
F
|
L
|
T
|
R
|
L
|
F
|
E
|
G
|
310 |
S
|
G
|
E
|
A
|
R
|
G
|
G
|
G
|
R
|
S
|
320 |
R
|
E
|
G
|
T
|
M
|
E
|
L
|
R
|
T
|
T
|
330 |
P
|
Q
|
L
|
K
|
V
|
V
|
G
|
Q
|
G
|
R
|
340 |
G
|
N
|
G
|
D
|
P
|
G
|
G
|
G
|
M
|
E
|
350 |
K
|
D
|
G
|
P
|
E
|
W
|
D
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
12-epi LTB4, LTB4, 12S-HPETE, 12R-HETE, 20-hydroxy-LTB4, 15S-HETE, 12S-HETE, 12-hydroxyheptadecatrienoic acid
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available