GPCRdb

substance P

Agent/drug
Bioactivity

substance P

SMILES	None
InChIKey	ADNPLDHMAVUMIW-CUZNLEPHSA-N
Sequence	RPKPQQFFGLM

Chemical Properties

Hydrogen bond acceptors	None
Hydrogen bond donors	None
Rotatable bonds	None
Molecular weight (Da)

Database connections

Guide To Pharmacology ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7RMI 7P00 7RMH 7RMG 7P02 7VDM 8U26

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NK₁	NK1R	Human	Tachykinin	A	pKi	8.50	9.40	10.30	Guide to Pharmacology
NK₁	NK1R	Human	Tachykinin	A	pKd	8.60	8.60	8.60	Guide to Pharmacology
NK₁	NK1R	Guinea pig	Tachykinin	A	pKi	7.30	7.30	7.30	ChEMBL
NK₁	NK1R	Rat	Tachykinin	A	pKi	8.96	8.96	8.96	ChEMBL
NK₁	NK1R	Human	Tachykinin	A	pKi	8.80	8.80	8.80	ChEMBL
NK₁	NK1R	Human	Tachykinin	A	pKi	8.55	9.66	10.38	PDSP Ki database
NK₁	NK1R	Guinea pig	Tachykinin	A	pKi	9.62	9.93	10.23	PDSP Ki database
NK₁	NK1R	Rat	Tachykinin	A	pKi	8.99	9.63	10.27	PDSP Ki database
NK₂	NK2R	Human	Tachykinin	A	pKi	5.90	6.40	6.90	Guide to Pharmacology
NK₂	NK2R	Human	Tachykinin	A	pKi	6.89	6.89	6.89	PDSP Ki database
NK₂	NK2R	Human	Tachykinin	A	pKi	6.99	6.99	6.99	ChEMBL
NK₃	NK3R	Human	Tachykinin	A	pKi	5.00	5.50	6.00	Guide to Pharmacology
NK₃	NK3R	Mouse	Tachykinin	A	pKi	5.30	5.30	5.30	Guide to Pharmacology
NK₃	NK3R	Human	Tachykinin	A	pKi	5.89	5.89	5.89	PDSP Ki database

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

ghrelin	GHSR	Human	Ghrelin	A	pEC50	7.18	7.18	7.18	ChEMBL
MRGPRX2	MRGX2	Human	A orphans	A	pEC50	5.97	5.97	5.97	Guide to Pharmacology
NK₁	NK1R	Guinea pig	Tachykinin	A	pIC50	10.15	10.15	10.15	ChEMBL
NK₁	NK1R	Guinea pig	Tachykinin	A	pEC50	8.25	8.52	9.00	ChEMBL
NK₁	NK1R	Rat	Tachykinin	A	pIC50	8.82	9.50	9.92	ChEMBL
NK₁	NK1R	Human	Tachykinin	A	pIC50	8.77	9.16	9.92	ChEMBL
NK₁	NK1R	Human	Tachykinin	A	pEC50	9.00	9.42	10.24	ChEMBL
NK₂	NK2R	Golden hamster	Tachykinin	A	pIC50	6.83	6.83	6.83	ChEMBL
NK₂	NK2R	Rat	Tachykinin	A	pIC50	6.70	6.70	6.70	ChEMBL
NK₂	NK2R	Rat	Tachykinin	A	pEC50	6.78	7.52	9.00	ChEMBL
NK₂	NK2R	Human	Tachykinin	A	pIC50	6.61	6.61	6.61	ChEMBL
NK₃	NK3R	Guinea pig	Tachykinin	A	pIC50	6.14	6.14	6.14	ChEMBL
NK₃	NK3R	Rat	Tachykinin	A	pEC50	5.12	5.12	5.12	ChEMBL
NK₃	NK3R	Rat	Tachykinin	A	pIC50	6.89	6.89	6.89	ChEMBL
NK₃	NK3R	Human	Tachykinin	A	pEC50	6.10	6.10	6.10	ChEMBL
NK₃	NK3R	Human	Tachykinin	A	pIC50	6.90	6.90	6.90	ChEMBL

Showing 1 to 16 of 16 entries

substance P

Drug properties

Molecular type	Peptide
Physiological/Surrogate	Endogenous
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

Guide To Pharmacology ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7RMI 7P00 7RMH 7RMG 7P02 7VDM 8U26

Compound is not listed as a drug.