OXE receptor (oxer1_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Leukotriene receptors OXE receptor
GENE
OXER1 (GPR170, TG1019)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Oxoeicosanoid receptor 1, 5-oxo-ETE G-protein coupled receptor, G-protein coupled receptor 170, G-protein coupled receptor R527, G-protein coupled receptor TG1019
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
L
|
C
|
H
|
R
|
G
|
G
|
Q
|
L
|
I
|
10 |
V
|
P
|
I
|
I
|
P
|
L
|
C
|
P
|
E
|
H
|
20 |
S
|
C
|
R
|
G
|
R
|
R
|
L
|
Q
|
N
|
L
|
30 |
L
|
S
|
G
|
P
|
W
|
P
|
K
|
Q
|
P
|
M
|
40 |
E
|
L
|
H
|
N
|
L
|
S
|
S
|
P
|
S
|
P
|
50 |
S
|
L
|
S
|
S
|
S
|
V
|
L
|
P
|
P
|
S
|
60 |
F
|
S
|
P
|
S
|
P
|
S
|
S
|
A
|
P
|
S
|
70 |
A
|
F
|
T
|
T
|
V
|
G
|
G
|
S
|
S
|
G
|
80 |
G
|
P
|
C
|
H
|
P
|
T
|
S
|
S
|
S
|
L
|
90 |
TM1 | |||||||||
V
|
S
|
A
|
F
|
L
|
A
|
P
|
I
|
L
|
A
|
100 |
L
|
E
|
F
|
V
|
L
|
G
|
L
|
V
|
G
|
N
|
110 |
S
|
L
|
A
|
L
|
F
|
I
|
F
|
C
|
I
|
H
|
120 |
ICL1 | TM2 | ||||||||
T
|
R
|
P
|
W
|
T
|
S
|
N
|
T
|
V
|
F
|
130 |
L
|
V
|
S
|
L
|
V
|
A
|
A
|
D
|
F
|
L
|
140 |
L
|
I
|
S
|
N
|
L
|
P
|
L
|
R
|
V
|
D
|
150 |
ECL1 | |||||||||
Y
|
Y
|
L
|
L
|
H
|
E
|
T
|
W
|
R
|
F
|
160 |
TM3 | |||||||||
G
|
A
|
A
|
A
|
C
|
K
|
V
|
N
|
L
|
F
|
170 |
M
|
L
|
S
|
T
|
N
|
R
|
T
|
A
|
S
|
V
|
180 |
V
|
F
|
L
|
T
|
A
|
I
|
A
|
L
|
N
|
R
|
190 |
ICL2 | |||||||||
Y
|
L
|
K
|
V
|
V
|
Q
|
P
|
H
|
H
|
V
|
200 |
TM4 | |||||||||
L
|
S
|
R
|
A
|
S
|
V
|
G
|
A
|
A
|
A
|
210 |
R
|
V
|
A
|
G
|
G
|
L
|
W
|
V
|
G
|
I
|
220 |
L
|
L
|
L
|
N
|
G
|
H
|
L
|
L
|
L
|
S
|
230 |
ECL2 | |||||||||
T
|
F
|
S
|
G
|
P
|
S
|
C
|
L
|
S
|
Y
|
240 |
TM5 | |||||||||
R
|
V
|
G
|
T
|
K
|
P
|
S
|
A
|
S
|
L
|
250 |
R
|
W
|
H
|
Q
|
A
|
L
|
Y
|
L
|
L
|
E
|
260 |
F
|
F
|
L
|
P
|
L
|
A
|
L
|
I
|
L
|
F
|
270 |
A
|
I
|
V
|
S
|
I
|
G
|
L
|
T
|
I
|
R
|
280 |
ICL3 | TM6 | ||||||||
N
|
R
|
G
|
L
|
G
|
G
|
Q
|
A
|
G
|
P
|
290 |
Q
|
R
|
A
|
M
|
R
|
V
|
L
|
A
|
M
|
V
|
300 |
V
|
A
|
V
|
Y
|
T
|
I
|
C
|
F
|
L
|
P
|
310 |
S
|
I
|
I
|
F
|
G
|
M
|
A
|
S
|
M
|
V
|
320 |
ECL3 | |||||||||
A
|
F
|
W
|
L
|
S
|
A
|
C
|
R
|
S
|
L
|
330 |
TM7 | |||||||||
D
|
L
|
C
|
T
|
Q
|
L
|
F
|
H
|
G
|
S
|
340 |
L
|
A
|
F
|
T
|
Y
|
L
|
N
|
S
|
V
|
L
|
350 |
H8 | |||||||||
D
|
P
|
V
|
L
|
Y
|
C
|
F
|
S
|
S
|
P
|
360 |
N
|
F
|
L
|
H
|
Q
|
S
|
R
|
A
|
L
|
L
|
370 |
C-term | |||||||||
G
|
L
|
T
|
R
|
G
|
R
|
Q
|
G
|
P
|
V
|
380 |
S
|
D
|
E
|
S
|
S
|
Y
|
Q
|
P
|
S
|
R
|
390 |
Q
|
W
|
R
|
Y
|
R
|
E
|
A
|
S
|
R
|
K
|
400 |
A
|
E
|
A
|
I
|
G
|
K
|
L
|
K
|
V
|
Q
|
410 |
G
|
E
|
V
|
S
|
L
|
E
|
K
|
E
|
G
|
S
|
420 |
S
|
Q
|
G
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-oxo-12-HETE, 5-oxo-C20:3, 5-oxo-15-HETE, 5S-HETE, 5-oxo-ETE, 5-oxo-ODE, 5S-HPETE, 5-oxo-20-HETE
STRUCTURE MODELS
STRUCTURES
No structures available