ccr5_human
NAME
6AKX
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
ccr5_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
|
D
|
Y
|
Q
|
V
|
S
|
S
|
P
|
I
|
Y
|
10 |
D
|
I
|
N
|
Y
|
Y
|
T
|
S
|
E
|
P
|
C
|
20 |
TM1 | |||||||||
Q
|
K
|
I
|
N
|
V
|
K
|
Q
|
I
|
A
|
A
|
30 |
R
|
L
|
L
|
P
|
P
|
L
|
Y
|
S
|
L
|
V
|
40 |
F
|
I
|
F
|
G
|
F
|
V
|
G
|
N
|
M
|
L
|
50 |
|
|||||||||
V
|
I
|
L
|
I
|
L
|
I
|
N
|
C
|
K
|
R
|
60 |
ICL1 | TM2 | ||||||||
L
|
K
|
S
|
M
|
T
|
D
|
I
|
Y
|
L
|
L
|
70 |
N
|
L
|
A
|
I
|
S
|
D
|
L
|
F
|
F
|
L
|
80 |
L
|
T
|
V
|
P
|
F
|
W
|
A
|
H
|
Y
|
A
|
90 |
ECL1 | TM3 | ||||||||
A
|
A
|
Q
|
W
|
D
|
F
|
G
|
N
|
T
|
M
|
100 |
C
|
Q
|
L
|
L
|
T
|
G
|
L
|
Y
|
F
|
I
|
110 |
G
|
F
|
F
|
S
|
G
|
I
|
F
|
F
|
I
|
I
|
120 |
L
|
L
|
T
|
I
|
D
|
R
|
Y
|
L
|
A
|
V
|
130 |
ICL2 | |||||||||
V
|
H
|
A
|
V
|
F
|
A
|
L
|
K
|
A
|
R
|
140 |
TM4 | |||||||||
T
|
V
|
T
|
F
|
G
|
V
|
V
|
T
|
S
|
V
|
150 |
I
|
T
|
W
|
V
|
V
|
A
|
V
|
F
|
A
|
S
|
160 |
|
|||||||||
L
|
P
|
G
|
I
|
I
|
F
|
T
|
R
|
S
|
Q
|
170 |
ECL2 | |||||||||
K
|
E
|
G
|
L
|
H
|
Y
|
T
|
C
|
S
|
S
|
180 |
TM5 | |||||||||
H
|
F
|
P
|
Y
|
S
|
Q
|
Y
|
Q
|
F
|
W
|
190 |
K
|
N
|
F
|
Q
|
T
|
L
|
K
|
I
|
V
|
I
|
200 |
L
|
G
|
L
|
V
|
L
|
P
|
L
|
L
|
V
|
M
|
210 |
V
|
I
|
C
|
Y
|
S
|
G
|
I
|
L
|
K
|
T
|
220 |
|
|
|
||||||||
ICL3 | TM6 | |||||||||
L
|
L
|
R
|
C
|
R
|
N
|
E
|
K
|
K
|
R
|
|
230 |
|
|||||||||
H
|
R
|
A
|
V
|
R
|
L
|
I
|
F
|
T
|
I
|
240 |
M
|
I
|
V
|
Y
|
F
|
L
|
F
|
W
|
A
|
P
|
250 |
Y
|
N
|
I
|
V
|
L
|
L
|
L
|
N
|
T
|
F
|
260 |
ECL3 | TM7 | ||||||||||
Q
|
E
|
F
|
F
|
G
|
L
|
N
|
N
|
C
|
S
|
||
270 |
S
|
S
|
N
|
R
|
L
|
D
|
Q
|
A
|
M
|
Q
|
280 |
V
|
T
|
E
|
T
|
L
|
G
|
M
|
T
|
H
|
C
|
290 |
C
|
I
|
N
|
P
|
I
|
I
|
Y
|
A
|
F
|
V
|
300 |
|
|||||||||
H8 | |||||||||
G
|
E
|
K
|
F
|
R
|
N
|
Y
|
L
|
L
|
V
|
310 |
|
|||||||||
C-term | |||||||||
F
|
F
|
Q
|
K
|
H
|
I
|
A
|
K
|
R
|
F
|
320 |
|
|
|
|
|
|
|
|
|
|
C
|
K
|
C
|
C
|
S
|
I
|
F
|
Q
|
Q
|
E
|
330 |
|
|
|
|
|
|
|
|
|
|
A
|
P
|
E
|
R
|
A
|
S
|
S
|
V
|
Y
|
T
|
340 |
|
|
|
|
|
|
|
|
|
|
R
|
S
|
T
|
G
|
E
|
Q
|
E
|
I
|
S
|
V
|
350 |
|
|
G
|
L
|
|
|
|
|
|
|
|
|
|
|
|
Expression | ||||||||||
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|
|
|
|
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|
|
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|||||||||
N-term | |||||||||
|
D
|
Y
|
Q
|
V
|
S
|
S
|
P
|
I
|
Y
|
10 |
D
|
I
|
N
|
Y
|
Y
|
T
|
S
|
E
|
P
|
C
|
20 |
TM1 | |||||||||
Q
|
K
|
I
|
N
|
V
|
K
|
Q
|
I
|
A
|
A
|
30 |
R
|
L
|
L
|
P
|
P
|
L
|
Y
|
S
|
L
|
V
|
40 |
F
|
I
|
F
|
G
|
F
|
V
|
G
|
N
|
M
|
L
|
50 |
|
|||||||||
V
|
I
|
L
|
I
|
L
|
I
|
N
|
Y
|
K
|
R
|
60 |
ICL1 | TM2 | ||||||||
L
|
K
|
S
|
M
|
T
|
D
|
I
|
Y
|
L
|
L
|
70 |
N
|
L
|
A
|
I
|
S
|
D
|
L
|
F
|
F
|
L
|
80 |
L
|
T
|
V
|
P
|
F
|
W
|
A
|
H
|
Y
|
A
|
90 |
ECL1 | TM3 | ||||||||
A
|
A
|
Q
|
W
|
D
|
F
|
G
|
N
|
T
|
M
|
100 |
C
|
Q
|
L
|
L
|
T
|
G
|
L
|
Y
|
F
|
I
|
110 |
G
|
F
|
F
|
S
|
G
|
I
|
F
|
F
|
I
|
I
|
120 |
L
|
L
|
T
|
I
|
D
|
R
|
Y
|
L
|
A
|
V
|
130 |
ICL2 | |||||||||
V
|
H
|
A
|
V
|
F
|
A
|
L
|
K
|
A
|
R
|
140 |
TM4 | |||||||||
T
|
V
|
T
|
F
|
G
|
V
|
V
|
T
|
S
|
V
|
150 |
I
|
T
|
W
|
V
|
V
|
A
|
V
|
F
|
A
|
S
|
160 |
|
|||||||||
L
|
P
|
N
|
I
|
I
|
F
|
T
|
R
|
S
|
Q
|
170 |
ECL2 | |||||||||
K
|
E
|
G
|
L
|
H
|
Y
|
T
|
C
|
S
|
S
|
180 |
TM5 | |||||||||
H
|
F
|
P
|
Y
|
S
|
Q
|
Y
|
Q
|
F
|
W
|
190 |
K
|
N
|
F
|
Q
|
T
|
L
|
K
|
I
|
V
|
I
|
200 |
L
|
G
|
L
|
V
|
L
|
P
|
L
|
L
|
V
|
M
|
210 |
V
|
I
|
C
|
Y
|
S
|
G
|
I
|
L
|
K
|
T
|
220 |
|
|||
L
|
L
|
R
|
|
|
|
|
|
|
|
|
|
|
|
Rubredoxin | |||||||||
|
|
|
|
|
|
|
|
|
|
|
|||||||
TM6 | |||||||
E
|
K
|
K
|
R
|
H
|
R
|
D
|
V
|
234 |
R
|
L
|
I
|
F
|
T
|
I
|
M
|
I
|
V
|
Y
|
244 |
F
|
L
|
F
|
W
|
A
|
P
|
Y
|
N
|
I
|
V
|
254 |
L
|
L
|
L
|
N
|
T
|
F
|
Q
|
E
|
F
|
F
|
264 |
ECL3 | TM7 | ||||||||
G
|
L
|
N
|
N
|
C
|
S
|
S
|
S
|
N
|
R
|
274 |
L
|
D
|
Q
|
A
|
M
|
Q
|
V
|
T
|
E
|
T
|
284 |
L
|
G
|
M
|
T
|
H
|
C
|
C
|
I
|
N
|
P
|
294 |
|
|||||||||
H8 | |||||||||
I
|
I
|
Y
|
A
|
F
|
V
|
G
|
E
|
E
|
F
|
304 |
R
|
N
|
Y
|
L
|
L
|
V
|
F
|
F
|
Q
|
K
|
314 |
|
|||||
C-term | |||||
H
|
I
|
A
|
K
|
R
|
|
|
|
|
|
|
|
|
|
|
|
|
Expression | ||||||||||
|
|
|
|
|
|
|
|
|
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
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|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|---|---|
58 | | C | Y |
163 | | G | N |
233 | | A | D |
303 | | K | E |
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
Protein_type: auto
Name: Expression tag
Sequence: None
Deletions:
Positions: C-term_2 None:None
Presence in Crystal:YES
Remarks: None
Protein_type: auto
Name: Expression tag
Sequence: None
Deletions:
Positions: N-term_0 None:None
Presence in Crystal:YES
Remarks: None
Protein_type: fusion
Name: Rubredoxin
Sequence: None
Deletions:
Positions: Within Receptor_1 224:224
Presence in Crystal:YES
Remarks: None
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|