5ht2b_human
NAME
6DS0
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
5ht2b_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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A
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L
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S
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Y
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R
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V
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S
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E
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L
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10 |
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Q
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S
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T
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I
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P
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E
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H
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I
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L
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Q
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20 |
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S
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T
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F
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V
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H
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V
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I
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S
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S
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N
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30 |
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|||||
W
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S
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G
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L
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Q
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T
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E
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S
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I
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P
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40 |
E
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E
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M
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K
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Q
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I
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V
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E
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E
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Q
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50 |
TM1 | |||||||||
G
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N
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K
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L
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H
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W
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A
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A
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L
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L
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60 |
I
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L
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M
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V
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I
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I
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P
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T
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I
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G
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70 |
G
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N
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T
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L
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V
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I
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L
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A
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V
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S
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80 |
ICL1 | TM2 | ||||||||
L
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E
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K
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K
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L
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Q
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Y
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A
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T
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N
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90 |
Y
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F
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L
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M
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S
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L
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A
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V
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A
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D
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100 |
L
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L
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V
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G
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L
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F
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V
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M
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P
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I
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110 |
A
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L
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L
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T
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I
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M
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F
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E
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A
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M
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120 |
ECL1 | TM3 | ||||||||
W
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P
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L
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P
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L
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V
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L
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C
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P
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A
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130 |
W
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L
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F
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L
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D
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V
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L
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F
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S
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T
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140 |
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|||||||||
A
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S
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I
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M
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H
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L
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C
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A
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I
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S
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150 |
V
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D
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R
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Y
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I
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A
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I
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K
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K
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P
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160 |
ICL2 | TM4 | ||||||||
I
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Q
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A
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N
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Q
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Y
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N
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S
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R
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A
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170 |
T
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A
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F
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I
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K
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I
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T
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V
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V
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W
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180 |
L
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I
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S
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I
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G
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I
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A
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I
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P
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V
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190 |
ECL2 | |||||||||
P
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I
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K
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G
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I
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E
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T
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D
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V
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D
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200 |
N
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P
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N
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N
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I
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T
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C
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V
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L
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T
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210 |
TM5 | |||||||||
K
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E
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R
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F
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G
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D
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F
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M
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L
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F
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220 |
G
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S
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L
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A
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A
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F
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F
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T
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P
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L
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230 |
A
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I
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M
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I
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V
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T
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Y
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F
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L
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T
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240 |
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||||||||
I
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H
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A
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L
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Q
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K
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K
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A
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Y
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L
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250 |
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ICL3 | |||||||||
V
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K
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N
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K
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P
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P
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Q
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R
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L
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T
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260 |
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W
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L
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T
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V
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S
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T
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V
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F
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Q
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R
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270 |
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D
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E
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T
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P
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C
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S
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S
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P
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E
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K
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280 |
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V
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A
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M
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L
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D
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G
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S
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R
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K
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D
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290 |
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K
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A
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L
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P
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N
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S
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G
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D
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E
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T
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300 |
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L
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M
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R
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R
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T
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S
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T
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I
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G
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K
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310 |
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TM6 | |||||||||
K
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S
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V
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Q
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T
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I
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S
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N
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E
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Q
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320 |
R
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A
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S
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K
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V
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L
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G
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I
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V
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F
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330 |
F
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L
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F
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L
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L
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M
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W
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C
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P
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F
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340 |
F
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I
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T
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N
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I
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T
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L
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V
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L
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C
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350 |
ECL3 | TM7 | ||||||||
D
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S
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C
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N
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Q
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T
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T
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L
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Q
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M
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360 |
L
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L
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E
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I
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F
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V
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W
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I
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G
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Y
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370 |
V
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S
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S
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G
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V
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N
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P
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L
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V
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Y
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380 |
H8 | |||||||||
T
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L
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F
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N
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K
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T
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F
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R
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D
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A
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390 |
F
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G
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R
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Y
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I
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T
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C
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N
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Y
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R
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400 |
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C-term | |||||||||
A
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T
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K
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S
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V
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K
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T
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L
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R
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K
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410 |
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R
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S
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S
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K
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I
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Y
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F
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R
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N
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P
|
420 |
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M
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A
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E
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N
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S
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K
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F
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F
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K
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K
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430 |
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|
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H
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G
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I
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R
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N
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G
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I
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N
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P
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A
|
440 |
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|
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M
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Y
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Q
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S
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P
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M
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R
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L
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R
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S
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450 |
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S
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T
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I
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Q
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S
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S
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S
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I
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I
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L
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460 |
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L
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D
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T
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L
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L
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L
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T
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E
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N
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E
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470 |
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|
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G
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D
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K
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T
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E
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E
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Q
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V
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S
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Y
|
480 |
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V
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|||||||||
N-term | |||||||||
|
T
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E
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S
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I
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P
|
E
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E
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M
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K
|
44 |
Q
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I
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V
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E
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E
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Q
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G
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N
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K
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L
|
54 |
TM1 | |||||||||
H
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W
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A
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A
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L
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L
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I
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L
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M
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V
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64 |
I
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I
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P
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T
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I
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G
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G
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N
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T
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L
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74 |
V
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I
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L
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A
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V
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S
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L
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E
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K
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K
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84 |
ICL1 | TM2 | ||||||||
L
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Q
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Y
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A
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T
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N
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Y
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F
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L
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M
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94 |
S
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L
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A
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V
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A
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D
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L
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L
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V
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G
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104 |
L
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F
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V
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M
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P
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I
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A
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L
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L
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T
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114 |
ECL1 | |||||||||
I
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M
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F
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E
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A
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M
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W
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P
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L
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P
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124 |
TM3 | |||||||||
L
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V
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L
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C
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P
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A
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W
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L
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F
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L
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134 |
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|||||||||
D
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V
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L
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F
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S
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T
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A
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S
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I
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W
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144 |
H
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L
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C
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A
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I
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S
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V
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D
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R
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Y
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154 |
ICL2 | |||||||||
I
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A
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I
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K
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K
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P
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I
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Q
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A
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N
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164 |
TM4 | |||||||||
Q
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Y
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N
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S
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R
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A
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T
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A
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F
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I
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174 |
K
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I
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T
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V
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V
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W
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L
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I
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S
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I
|
184 |
G
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I
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A
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I
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P
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V
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P
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I
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K
|
G
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194 |
ECL2 | |||||||||
I
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E
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T
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D
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V
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D
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N
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P
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N
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N
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204 |
I
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T
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C
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V
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L
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T
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K
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E
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R
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F
|
214 |
TM5 | |||||||||
G
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D
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F
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M
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L
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F
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G
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S
|
L
|
A
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224 |
A
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F
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F
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T
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P
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L
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A
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I
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M
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I
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234 |
V
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T
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Y
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F
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L
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T
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I
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H
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A
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L
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244 |
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Q
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K
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K
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A
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BRIL (b562R | ||||||||||
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TM6 | |||||||
Q
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T
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I
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S
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N
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E
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Q
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R
|
321 |
A
|
S
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K
|
V
|
L
|
G
|
I
|
V
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F
|
F
|
331 |
L
|
F
|
L
|
L
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M
|
W
|
C
|
P
|
F
|
F
|
341 |
I
|
T
|
N
|
I
|
T
|
L
|
V
|
L
|
C
|
D
|
351 |
ECL3 | TM7 | ||||||||
S
|
C
|
N
|
Q
|
T
|
T
|
L
|
Q
|
M
|
L
|
361 |
L
|
E
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I
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F
|
V
|
W
|
I
|
G
|
Y
|
V
|
371 |
S
|
S
|
G
|
V
|
N
|
P
|
L
|
V
|
Y
|
T
|
381 |
H8 | |||||||||
L
|
F
|
N
|
K
|
T
|
F
|
R
|
D
|
A
|
F
|
391 |
C-term | |||||||||
G
|
R
|
Y
|
I
|
T
|
C
|
N
|
Y
|
R
|
A
|
401 |
|
|||
T
|
K
|
S
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|---|---|
144 | | M | W |
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
Protein_type: fusion
Name: BRIL (b562RIL)
Sequence: None
Deletions:
Positions: Within Receptor_0 249:249
Presence in Crystal:YES
Remarks: None
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|