gabr1_human
NAME
6W2Y
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
gabr1_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
|
L
|
L
|
L
|
L
|
L
|
L
|
A
|
P
|
L
|
10 |
|
|
|
|
|
|
|
|
|
|
F
|
L
|
R
|
P
|
P
|
G
|
A
|
G
|
G
|
A
|
20 |
|
|
|
|
|
|
|
|
|
|
Q
|
T
|
P
|
N
|
A
|
T
|
S
|
E
|
G
|
C
|
30 |
Q
|
I
|
I
|
H
|
P
|
P
|
W
|
E
|
G
|
G
|
40 |
I
|
R
|
Y
|
R
|
G
|
L
|
T
|
R
|
D
|
Q
|
50 |
V
|
K
|
A
|
I
|
N
|
F
|
L
|
P
|
V
|
D
|
60 |
Y
|
E
|
I
|
E
|
Y
|
V
|
C
|
R
|
G
|
E
|
70 |
R
|
E
|
V
|
V
|
G
|
P
|
K
|
V
|
R
|
K
|
80 |
C
|
L
|
A
|
N
|
G
|
S
|
W
|
T
|
D
|
M
|
90 |
D
|
T
|
P
|
S
|
R
|
C
|
V
|
R
|
I
|
C
|
100 |
S
|
K
|
S
|
Y
|
L
|
T
|
L
|
E
|
N
|
G
|
110 |
K
|
V
|
F
|
L
|
T
|
G
|
G
|
D
|
L
|
P
|
120 |
A
|
L
|
D
|
G
|
A
|
R
|
V
|
D
|
F
|
R
|
130 |
C
|
D
|
P
|
D
|
F
|
H
|
L
|
V
|
G
|
S
|
140 |
S
|
R
|
S
|
I
|
C
|
S
|
Q
|
G
|
Q
|
W
|
150 |
S
|
T
|
P
|
K
|
P
|
H
|
C
|
Q
|
V
|
N
|
160 |
R
|
T
|
P
|
H
|
S
|
E
|
R
|
R
|
A
|
V
|
170 |
Y
|
I
|
G
|
A
|
L
|
F
|
P
|
M
|
S
|
G
|
180 |
G
|
W
|
P
|
G
|
G
|
Q
|
A
|
C
|
Q
|
P
|
190 |
A
|
V
|
E
|
M
|
A
|
L
|
E
|
D
|
V
|
N
|
200 |
S
|
R
|
R
|
D
|
I
|
L
|
P
|
D
|
Y
|
E
|
210 |
L
|
K
|
L
|
I
|
H
|
H
|
D
|
S
|
K
|
C
|
220 |
D
|
P
|
G
|
Q
|
A
|
T
|
K
|
Y
|
L
|
Y
|
230 |
E
|
L
|
L
|
Y
|
N
|
D
|
P
|
I
|
K
|
I
|
240 |
I
|
L
|
M
|
P
|
G
|
C
|
S
|
S
|
V
|
S
|
250 |
T
|
L
|
V
|
A
|
E
|
A
|
A
|
R
|
M
|
W
|
260 |
N
|
L
|
I
|
V
|
L
|
S
|
Y
|
G
|
S
|
S
|
270 |
S
|
P
|
A
|
L
|
S
|
N
|
R
|
Q
|
R
|
F
|
280 |
P
|
T
|
F
|
F
|
R
|
T
|
H
|
P
|
S
|
A
|
290 |
T
|
L
|
H
|
N
|
P
|
T
|
R
|
V
|
K
|
L
|
300 |
F
|
E
|
K
|
W
|
G
|
W
|
K
|
K
|
I
|
A
|
310 |
T
|
I
|
Q
|
Q
|
T
|
T
|
E
|
V
|
F
|
T
|
320 |
S
|
T
|
L
|
D
|
D
|
L
|
E
|
E
|
R
|
V
|
330 |
K
|
E
|
A
|
G
|
I
|
E
|
I
|
T
|
F
|
R
|
340 |
Q
|
S
|
F
|
F
|
S
|
D
|
P
|
A
|
V
|
P
|
350 |
V
|
K
|
N
|
L
|
K
|
R
|
Q
|
D
|
A
|
R
|
360 |
I
|
I
|
V
|
G
|
L
|
F
|
Y
|
E
|
T
|
E
|
370 |
A
|
R
|
K
|
V
|
F
|
C
|
E
|
V
|
Y
|
K
|
380 |
E
|
R
|
L
|
F
|
G
|
K
|
K
|
Y
|
V
|
W
|
390 |
F
|
L
|
I
|
G
|
W
|
Y
|
A
|
D
|
N
|
W
|
400 |
F
|
K
|
I
|
Y
|
D
|
P
|
S
|
I
|
N
|
C
|
410 |
T
|
V
|
D
|
E
|
M
|
T
|
E
|
A
|
V
|
E
|
420 |
G
|
H
|
I
|
T
|
T
|
E
|
I
|
V
|
M
|
L
|
430 |
N
|
P
|
A
|
N
|
T
|
R
|
S
|
I
|
S
|
N
|
440 |
M
|
T
|
S
|
Q
|
E
|
F
|
V
|
E
|
K
|
L
|
450 |
T
|
K
|
R
|
L
|
K
|
R
|
H
|
P
|
E
|
E
|
460 |
T
|
G
|
G
|
F
|
Q
|
E
|
A
|
P
|
L
|
A
|
470 |
Y
|
D
|
A
|
I
|
W
|
A
|
L
|
A
|
L
|
A
|
480 |
L
|
N
|
K
|
T
|
S
|
G
|
G
|
G
|
G
|
R
|
490 |
S
|
G
|
V
|
R
|
L
|
E
|
D
|
F
|
N
|
Y
|
500 |
N
|
N
|
Q
|
T
|
I
|
T
|
D
|
Q
|
I
|
Y
|
510 |
R
|
A
|
M
|
N
|
S
|
S
|
S
|
F
|
E
|
G
|
520 |
V
|
S
|
G
|
H
|
V
|
V
|
F
|
D
|
A
|
S
|
530 |
G
|
S
|
R
|
M
|
A
|
W
|
T
|
L
|
I
|
E
|
540 |
Q
|
L
|
Q
|
G
|
G
|
S
|
Y
|
K
|
K
|
I
|
550 |
G
|
Y
|
Y
|
D
|
S
|
T
|
K
|
D
|
D
|
L
|
560 |
S
|
W
|
S
|
K
|
T
|
D
|
K
|
W
|
I
|
G
|
570 |
G
|
S
|
P
|
P
|
A
|
D
|
Q
|
T
|
L
|
V
|
580 |
I
|
K
|
T
|
F
|
R
|
F
|
L
|
S
|
Q
|
K
|
590 |
TM1 | |||||||||
L
|
F
|
I
|
S
|
V
|
S
|
V
|
L
|
S
|
S
|
600 |
L
|
G
|
I
|
V
|
L
|
A
|
V
|
V
|
C
|
L
|
610 |
ICL1 | |||||||||
S
|
F
|
N
|
I
|
Y
|
N
|
S
|
H
|
V
|
R
|
620 |
TM2 | |||||||||
Y
|
I
|
Q
|
N
|
S
|
Q
|
P
|
N
|
L
|
N
|
630 |
N
|
L
|
T
|
A
|
V
|
G
|
C
|
S
|
L
|
A
|
640 |
L
|
A
|
A
|
V
|
F
|
P
|
L
|
G
|
L
|
D
|
650 |
ECL1 | TM3 | ||||||||
G
|
Y
|
H
|
I
|
G
|
R
|
N
|
Q
|
F
|
P
|
660 |
F
|
V
|
C
|
Q
|
A
|
R
|
L
|
W
|
L
|
L
|
670 |
G
|
L
|
G
|
F
|
S
|
L
|
G
|
Y
|
G
|
S
|
680 |
M
|
F
|
T
|
K
|
I
|
W
|
W
|
V
|
H
|
T
|
690 |
ICL2 | |||||||||
V
|
F
|
T
|
K
|
K
|
E
|
E
|
K
|
K
|
E
|
700 |
TM4 | |||||||||
W
|
R
|
K
|
T
|
L
|
E
|
P
|
W
|
K
|
L
|
710 |
Y
|
A
|
T
|
V
|
G
|
L
|
L
|
V
|
G
|
M
|
720 |
D
|
V
|
L
|
T
|
L
|
A
|
I
|
W
|
Q
|
I
|
730 |
ECL2 | |||||||||
V
|
D
|
P
|
L
|
H
|
R
|
T
|
I
|
E
|
T
|
740 |
F
|
A
|
K
|
E
|
E
|
P
|
K
|
E
|
D
|
I
|
750 |
D
|
V
|
S
|
I
|
L
|
P
|
Q
|
L
|
E
|
H
|
760 |
TM5 | |||||||||
C
|
S
|
S
|
R
|
K
|
M
|
N
|
T
|
W
|
L
|
770 |
G
|
I
|
F
|
Y
|
G
|
Y
|
K
|
G
|
L
|
L
|
780 |
L
|
L
|
L
|
G
|
I
|
F
|
L
|
A
|
Y
|
E
|
790 |
ICL3 | |||||||||
T
|
K
|
S
|
V
|
S
|
T
|
E
|
K
|
I
|
N
|
800 |
TM6 | |||||||||
D
|
H
|
R
|
A
|
V
|
G
|
M
|
A
|
I
|
Y
|
810 |
N
|
V
|
A
|
V
|
L
|
C
|
L
|
I
|
T
|
A
|
820 |
ECL3 | |||||||||
P
|
V
|
T
|
M
|
I
|
L
|
S
|
S
|
Q
|
Q
|
830 |
TM7 | |||||||||
D
|
A
|
A
|
F
|
A
|
F
|
A
|
S
|
L
|
A
|
840 |
|
|
|
|
|
|
||||
I
|
V
|
F
|
S
|
S
|
Y
|
I
|
T
|
L
|
V
|
850 |
|
|
|
|
|
|
|
|
|
|
V
|
L
|
F
|
V
|
P
|
K
|
M
|
R
|
R
|
L
|
860 |
|
|
|
|
|
|
|
|
|
|
H8 | |||||||||
I
|
T
|
R
|
G
|
E
|
W
|
Q
|
S
|
E
|
A
|
870 |
|
|
|
|
|
|
|
|
|
|
Q
|
D
|
T
|
M
|
K
|
T
|
G
|
S
|
S
|
T
|
880 |
|
|
|
|
|
|
|
|
|
|
C-term | |||||||||
N
|
N
|
N
|
E
|
E
|
E
|
K
|
S
|
R
|
L
|
890 |
|
|
|
|
|
|
|
|
|
|
L
|
E
|
K
|
E
|
N
|
R
|
E
|
L
|
E
|
K
|
900 |
|
|
|
|
|
|
|
|
|
|
I
|
I
|
A
|
E
|
K
|
E
|
E
|
R
|
V
|
S
|
910 |
|
|
|
|
|
|
|
|
|
|
E
|
L
|
R
|
H
|
Q
|
L
|
Q
|
S
|
R
|
Q
|
920 |
|
|
|
|
|
|
|
|
|
|
Q
|
L
|
R
|
S
|
R
|
R
|
H
|
P
|
P
|
T
|
930 |
|
|
|
|
|
|
|
|
|
|
P
|
P
|
E
|
P
|
S
|
G
|
G
|
L
|
P
|
R
|
940 |
|
|
|
|
|
|
|
|
|
|
G
|
P
|
P
|
E
|
P
|
P
|
D
|
R
|
L
|
S
|
950 |
|
|
|
|
|
|
|
|
|
|
C
|
D
|
G
|
S
|
R
|
V
|
H
|
L
|
L
|
Y
|
960 |
|
K
|
|
|||||||||
N-term | |||||||||
|
C
|
Q
|
I
|
I
|
H
|
P
|
P
|
W
|
E
|
38 |
G
|
G
|
I
|
R
|
Y
|
R
|
G
|
L
|
T
|
R
|
48 |
D
|
Q
|
V
|
K
|
A
|
I
|
N
|
F
|
L
|
P
|
58 |
V
|
D
|
Y
|
E
|
I
|
E
|
Y
|
V
|
C
|
R
|
68 |
G
|
E
|
R
|
E
|
V
|
V
|
G
|
P
|
K
|
V
|
78 |
R
|
K
|
C
|
L
|
A
|
N
|
G
|
S
|
W
|
T
|
88 |
D
|
M
|
D
|
T
|
P
|
S
|
R
|
C
|
V
|
R
|
98 |
I
|
C
|
S
|
K
|
S
|
Y
|
L
|
T
|
L
|
E
|
108 |
N
|
G
|
K
|
V
|
F
|
L
|
T
|
G
|
G
|
D
|
118 |
L
|
P
|
A
|
L
|
D
|
G
|
A
|
R
|
V
|
D
|
128 |
F
|
R
|
C
|
D
|
P
|
D
|
F
|
H
|
L
|
V
|
138 |
G
|
S
|
S
|
R
|
S
|
I
|
C
|
S
|
Q
|
G
|
148 |
Q
|
W
|
S
|
T
|
P
|
K
|
P
|
H
|
C
|
Q
|
158 |
V
|
N
|
R
|
T
|
P
|
H
|
S
|
E
|
R
|
R
|
168 |
A
|
V
|
Y
|
I
|
G
|
A
|
L
|
F
|
P
|
M
|
178 |
S
|
G
|
G
|
W
|
P
|
G
|
G
|
Q
|
A
|
C
|
188 |
Q
|
P
|
A
|
V
|
E
|
M
|
A
|
L
|
E
|
D
|
198 |
V
|
N
|
S
|
R
|
R
|
D
|
I
|
L
|
P
|
D
|
208 |
Y
|
E
|
L
|
K
|
L
|
I
|
H
|
H
|
D
|
S
|
218 |
K
|
C
|
D
|
P
|
G
|
Q
|
A
|
T
|
K
|
Y
|
228 |
L
|
Y
|
E
|
L
|
L
|
Y
|
N
|
D
|
P
|
I
|
238 |
K
|
I
|
I
|
L
|
M
|
P
|
G
|
C
|
S
|
S
|
248 |
V
|
S
|
T
|
L
|
V
|
A
|
E
|
A
|
A
|
R
|
258 |
M
|
W
|
N
|
L
|
I
|
V
|
L
|
S
|
Y
|
G
|
268 |
S
|
S
|
S
|
P
|
A
|
L
|
S
|
N
|
R
|
Q
|
278 |
R
|
F
|
P
|
T
|
F
|
F
|
R
|
T
|
H
|
P
|
288 |
S
|
A
|
T
|
L
|
H
|
N
|
P
|
T
|
R
|
V
|
298 |
K
|
L
|
F
|
E
|
K
|
W
|
G
|
W
|
K
|
K
|
308 |
I
|
A
|
T
|
I
|
Q
|
Q
|
T
|
T
|
E
|
V
|
318 |
F
|
T
|
S
|
T
|
L
|
D
|
D
|
L
|
E
|
E
|
328 |
R
|
V
|
K
|
E
|
A
|
G
|
I
|
E
|
I
|
T
|
338 |
F
|
R
|
Q
|
S
|
F
|
F
|
S
|
D
|
P
|
A
|
348 |
V
|
P
|
V
|
K
|
N
|
L
|
K
|
R
|
Q
|
D
|
358 |
A
|
R
|
I
|
I
|
V
|
G
|
L
|
F
|
Y
|
E
|
368 |
T
|
E
|
A
|
R
|
K
|
V
|
F
|
C
|
E
|
V
|
378 |
Y
|
K
|
E
|
R
|
L
|
F
|
G
|
K
|
K
|
Y
|
388 |
V
|
W
|
F
|
L
|
I
|
G
|
W
|
Y
|
A
|
D
|
398 |
N
|
W
|
F
|
K
|
I
|
Y
|
D
|
P
|
S
|
I
|
408 |
N
|
C
|
T
|
V
|
D
|
E
|
M
|
T
|
E
|
A
|
418 |
V
|
E
|
G
|
H
|
I
|
T
|
T
|
E
|
I
|
V
|
428 |
M
|
L
|
N
|
P
|
A
|
N
|
T
|
R
|
S
|
I
|
438 |
S
|
N
|
M
|
T
|
S
|
Q
|
E
|
F
|
V
|
E
|
448 |
K
|
L
|
T
|
K
|
R
|
L
|
K
|
R
|
H
|
P
|
458 |
E
|
E
|
T
|
G
|
G
|
F
|
Q
|
E
|
A
|
P
|
468 |
L
|
A
|
Y
|
D
|
A
|
I
|
W
|
A
|
L
|
A
|
478 |
L
|
A
|
L
|
N
|
K
|
T
|
S
|
G
|
G
|
G
|
488 |
G
|
R
|
S
|
G
|
V
|
R
|
L
|
E
|
D
|
F
|
498 |
N
|
Y
|
N
|
N
|
Q
|
T
|
I
|
T
|
D
|
Q
|
508 |
I
|
Y
|
R
|
A
|
M
|
N
|
S
|
S
|
S
|
F
|
518 |
E
|
G
|
V
|
S
|
G
|
H
|
V
|
V
|
F
|
D
|
528 |
A
|
S
|
G
|
S
|
R
|
M
|
A
|
W
|
T
|
L
|
538 |
I
|
E
|
Q
|
L
|
Q
|
G
|
G
|
S
|
Y
|
K
|
548 |
K
|
I
|
G
|
Y
|
Y
|
D
|
S
|
T
|
K
|
D
|
558 |
D
|
L
|
S
|
W
|
S
|
K
|
T
|
D
|
K
|
W
|
568 |
I
|
G
|
G
|
S
|
P
|
P
|
A
|
D
|
Q
|
T
|
578 |
L
|
V
|
I
|
K
|
T
|
F
|
R
|
F
|
L
|
S
|
588 |
TM1 | |||||||||
Q
|
K
|
L
|
F
|
I
|
S
|
V
|
S
|
V
|
L
|
598 |
S
|
S
|
L
|
G
|
I
|
V
|
L
|
A
|
V
|
V
|
608 |
C
|
L
|
S
|
F
|
N
|
I
|
Y
|
N
|
S
|
H
|
618 |
ICL1 | TM2 | ||||||||
V
|
R
|
Y
|
I
|
Q
|
N
|
S
|
Q
|
P
|
N
|
628 |
L
|
N
|
N
|
L
|
T
|
A
|
V
|
G
|
C
|
S
|
638 |
L
|
A
|
L
|
A
|
A
|
V
|
F
|
P
|
L
|
G
|
648 |
ECL1 | |||||||||
L
|
D
|
G
|
Y
|
H
|
I
|
G
|
R
|
N
|
Q
|
658 |
TM3 | |||||||||
F
|
P
|
F
|
V
|
C
|
Q
|
A
|
R
|
L
|
W
|
668 |
L
|
L
|
G
|
L
|
G
|
F
|
S
|
L
|
G
|
Y
|
678 |
G
|
S
|
M
|
F
|
T
|
K
|
I
|
W
|
W
|
V
|
688 |
ICL2 | |||||||||
H
|
T
|
V
|
F
|
T
|
K
|
K
|
E
|
E
|
K
|
698 |
TM4 | |||||||||
K
|
E
|
W
|
R
|
K
|
T
|
L
|
E
|
P
|
W
|
708 |
K
|
L
|
Y
|
A
|
T
|
V
|
G
|
L
|
L
|
V
|
718 |
G
|
M
|
D
|
V
|
L
|
T
|
L
|
A
|
I
|
W
|
728 |
ECL2 | |||||||||
Q
|
I
|
V
|
D
|
P
|
L
|
H
|
R
|
T
|
I
|
738 |
E
|
T
|
F
|
A
|
K
|
E
|
E
|
P
|
K
|
E
|
748 |
D
|
I
|
D
|
V
|
S
|
I
|
L
|
P
|
Q
|
L
|
758 |
TM5 | |||||||||
E
|
H
|
C
|
S
|
S
|
R
|
K
|
M
|
N
|
T
|
768 |
W
|
L
|
G
|
I
|
F
|
Y
|
G
|
Y
|
K
|
G
|
778 |
L
|
L
|
L
|
L
|
L
|
G
|
I
|
F
|
L
|
A
|
788 |
ICL3 | |||||||||
Y
|
E
|
T
|
K
|
S
|
V
|
S
|
T
|
E
|
K
|
798 |
TM6 | |||||||||
I
|
N
|
D
|
H
|
R
|
A
|
V
|
G
|
M
|
A
|
808 |
I
|
Y
|
N
|
V
|
A
|
V
|
L
|
C
|
L
|
I
|
818 |
T
|
A
|
P
|
V
|
T
|
M
|
I
|
L
|
S
|
S
|
828 |
ECL3 | TM7 | ||||||||
Q
|
Q
|
D
|
A
|
A
|
F
|
A
|
F
|
A
|
S
|
838 |
|
||||||
L
|
A
|
I
|
V
|
F
|
S
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
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|
|
|
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|
|
DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|