sctr_human
NAME
7D3S
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
sctr_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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R
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P
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H
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L
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S
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P
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P
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L
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Q
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10 |
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Q
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L
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L
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L
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P
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V
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L
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L
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A
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C
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20 |
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||||||||
A
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A
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H
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S
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T
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G
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A
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L
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P
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R
|
30 |
L
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C
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D
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V
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L
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Q
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V
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L
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W
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E
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40 |
E
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Q
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D
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Q
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C
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L
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Q
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E
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L
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S
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50 |
R
|
E
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Q
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T
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G
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D
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L
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G
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T
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E
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60 |
Q
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P
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V
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P
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G
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C
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E
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G
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M
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W
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70 |
D
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N
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I
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S
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C
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W
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P
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S
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S
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V
|
80 |
P
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G
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R
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M
|
V
|
E
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V
|
E
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C
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P
|
90 |
R
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F
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L
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R
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M
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L
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T
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S
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R
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N
|
100 |
G
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S
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L
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F
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R
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N
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C
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T
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Q
|
D
|
110 |
G
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W
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S
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E
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T
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F
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P
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R
|
P
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N
|
120 |
L
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A
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C
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G
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V
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N
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V
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N
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D
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S
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130 |
TM1 | |||||||||
S
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N
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E
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K
|
R
|
H
|
S
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Y
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L
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L
|
140 |
K
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L
|
K
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V
|
M
|
Y
|
T
|
V
|
G
|
Y
|
150 |
S
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S
|
S
|
L
|
V
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M
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L
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L
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V
|
A
|
160 |
L
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G
|
I
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L
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C
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A
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F
|
R
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R
|
L
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170 |
ICL1 | TM2 | ||||||||
H
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C
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T
|
R
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N
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Y
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I
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H
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M
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H
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180 |
L
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F
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V
|
S
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F
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I
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L
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R
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A
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L
|
190 |
S
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N
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F
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I
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K
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D
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A
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V
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L
|
F
|
200 |
ECL1 | |||||||||
S
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S
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D
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D
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V
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T
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Y
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C
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D
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A
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210 |
TM3 | |||||||||
H
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R
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A
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G
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C
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K
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L
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V
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M
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V
|
220 |
L
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F
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Q
|
Y
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C
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I
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M
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A
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N
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Y
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230 |
S
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W
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L
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L
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V
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E
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G
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L
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Y
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L
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240 |
ICL2 | |||||||||
H
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T
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L
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L
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A
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I
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S
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F
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F
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S
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250 |
TM4 | |||||||||
E
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R
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K
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Y
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L
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Q
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G
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F
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V
|
A
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260 |
F
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G
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W
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G
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S
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P
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A
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I
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F
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V
|
270 |
A
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L
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W
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A
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I
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A
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R
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H
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F
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L
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280 |
ECL2 | |||||||||
E
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D
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V
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G
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C
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W
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D
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I
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N
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A
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290 |
TM5 | |||||||||
N
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A
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S
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I
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W
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W
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I
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I
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R
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G
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300 |
P
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V
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I
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L
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S
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I
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L
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I
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N
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F
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310 |
I
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L
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F
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I
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N
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I
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L
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R
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I
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L
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320 |
ICL3 | |||||||||
M
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R
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K
|
L
|
R
|
T
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Q
|
E
|
T
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R
|
330 |
TM6 | |||||||||
G
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N
|
E
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V
|
S
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H
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Y
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K
|
R
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L
|
340 |
A
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R
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S
|
T
|
L
|
L
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L
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I
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P
|
L
|
350 |
F
|
G
|
I
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H
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Y
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I
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V
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F
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A
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F
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360 |
ECL3 | TM7 | ||||||||
S
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P
|
E
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D
|
A
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M
|
E
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I
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Q
|
L
|
370 |
F
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F
|
E
|
L
|
A
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L
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G
|
S
|
F
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Q
|
380 |
G
|
L
|
V
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V
|
A
|
V
|
L
|
Y
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C
|
F
|
390 |
H8 | |||||||||
L
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N
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G
|
E
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V
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Q
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L
|
E
|
V
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Q
|
400 |
K
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K
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W
|
Q
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Q
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W
|
H
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L
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R
|
E
|
410 |
F
|
P
|
L
|
H
|
P
|
V
|
A
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S
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F
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S
|
420 |
C-term | |||||||||
N
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S
|
T
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K
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A
|
S
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H
|
L
|
E
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Q
|
430 |
S
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Q
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G
|
T
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C
|
R
|
T
|
S
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I
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I
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440 |
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|||||||||
N-term | |||||||||
|
H
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S
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T
|
G
|
A
|
L
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P
|
R
|
L
|
31 |
C
|
D
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V
|
L
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Q
|
V
|
L
|
W
|
E
|
E
|
41 |
Q
|
D
|
Q
|
C
|
L
|
Q
|
E
|
L
|
S
|
R
|
51 |
E
|
Q
|
T
|
G
|
D
|
L
|
G
|
T
|
E
|
Q
|
61 |
P
|
V
|
P
|
G
|
C
|
E
|
G
|
M
|
W
|
D
|
71 |
N
|
I
|
S
|
C
|
W
|
P
|
S
|
S
|
V
|
P
|
81 |
G
|
R
|
M
|
V
|
E
|
V
|
E
|
C
|
P
|
R
|
91 |
F
|
L
|
R
|
M
|
L
|
T
|
S
|
R
|
N
|
G
|
101 |
S
|
L
|
F
|
R
|
N
|
C
|
T
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Q
|
D
|
G
|
111 |
W
|
S
|
E
|
T
|
F
|
P
|
R
|
P
|
N
|
L
|
121 |
A
|
C
|
G
|
V
|
N
|
V
|
N
|
D
|
S
|
S
|
131 |
TM1 | |||||||||
N
|
E
|
K
|
R
|
H
|
S
|
Y
|
L
|
L
|
K
|
141 |
L
|
K
|
V
|
M
|
Y
|
T
|
V
|
G
|
Y
|
S
|
151 |
S
|
S
|
L
|
V
|
M
|
L
|
L
|
V
|
A
|
L
|
161 |
ICL1 | |||||||||
G
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I
|
L
|
C
|
A
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F
|
R
|
R
|
L
|
H
|
171 |
TM2 | |||||||||
C
|
T
|
R
|
N
|
Y
|
I
|
H
|
M
|
H
|
L
|
181 |
F
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V
|
S
|
F
|
I
|
L
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R
|
A
|
L
|
S
|
191 |
N
|
F
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I
|
K
|
D
|
A
|
V
|
L
|
F
|
S
|
201 |
ECL1 | |||||||||
S
|
D
|
D
|
V
|
T
|
Y
|
C
|
D
|
A
|
H
|
211 |
TM3 | |||||||||
R
|
A
|
G
|
C
|
K
|
L
|
V
|
M
|
V
|
L
|
221 |
F
|
Q
|
Y
|
C
|
I
|
M
|
A
|
N
|
Y
|
S
|
231 |
W
|
L
|
L
|
V
|
E
|
G
|
L
|
Y
|
L
|
H
|
241 |
ICL2 | |||||||||
T
|
L
|
L
|
A
|
I
|
S
|
F
|
F
|
S
|
E
|
251 |
TM4 | |||||||||
R
|
K
|
Y
|
L
|
Q
|
G
|
F
|
V
|
A
|
F
|
261 |
G
|
W
|
G
|
S
|
P
|
A
|
I
|
F
|
V
|
A
|
271 |
L
|
W
|
A
|
I
|
A
|
R
|
H
|
F
|
L
|
E
|
281 |
ECL2 | |||||||||
D
|
V
|
G
|
C
|
W
|
D
|
I
|
N
|
A
|
N
|
291 |
TM5 | |||||||||
A
|
S
|
I
|
W
|
W
|
I
|
I
|
R
|
G
|
P
|
301 |
V
|
I
|
L
|
S
|
I
|
L
|
I
|
N
|
F
|
I
|
311 |
L
|
F
|
I
|
N
|
I
|
L
|
R
|
I
|
L
|
M
|
321 |
ICL3 | |||||||||
R
|
K
|
L
|
R
|
T
|
Q
|
E
|
T
|
R
|
G
|
331 |
TM6 | |||||||||
N
|
E
|
V
|
S
|
H
|
Y
|
K
|
R
|
L
|
A
|
341 |
R
|
S
|
T
|
L
|
L
|
L
|
I
|
P
|
L
|
F
|
351 |
G
|
I
|
H
|
Y
|
I
|
V
|
F
|
A
|
F
|
S
|
361 |
ECL3 | TM7 | ||||||||
P
|
E
|
D
|
A
|
M
|
E
|
I
|
Q
|
L
|
F
|
371 |
F
|
E
|
L
|
A
|
L
|
G
|
S
|
F
|
Q
|
G
|
381 |
L
|
V
|
V
|
A
|
V
|
L
|
Y
|
C
|
F
|
L
|
391 |
H8 | |||||||||
N
|
G
|
E
|
V
|
Q
|
L
|
E
|
V
|
Q
|
K
|
401 |
K
|
W
|
Q
|
Q
|
W
|
H
|
L
|
R
|
E
|
F
|
411 |
P
|
L
|
H
|
P
|
V
|
A
|
S
|
F
|
S
|
N
|
421 |
C-term | |||||||||
S
|
T
|
K
|
A
|
S
|
H
|
L
|
E
|
Q
|
S
|
431 |
Q
|
G
|
T
|
C
|
R
|
T
|
S
|
I
|
I
|
440 |
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|