agrd1_human
NAME
7WU2
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
agrd1_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
|
E
|
K
|
L
|
L
|
R
|
L
|
C
|
C
|
W
|
10 |
|
|
|
|
|
|
|
|
|
|
Y
|
S
|
W
|
L
|
L
|
L
|
F
|
Y
|
Y
|
N
|
20 |
|
|
|
|
|
|
|
|
|
|
F
|
Q
|
V
|
R
|
G
|
V
|
Y
|
S
|
R
|
S
|
30 |
|
|
|
|
|
|
|
|
|
|
Q
|
D
|
H
|
P
|
G
|
F
|
Q
|
V
|
L
|
A
|
40 |
|
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|
|
|
|
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|
|
|
S
|
A
|
S
|
H
|
Y
|
W
|
P
|
L
|
E
|
N
|
50 |
|
|
|
|
|
|
|
|
|
|
V
|
D
|
G
|
I
|
H
|
E
|
L
|
Q
|
D
|
T
|
60 |
|
|
|
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|
|
|
|
|
|
T
|
G
|
D
|
I
|
V
|
E
|
G
|
K
|
V
|
N
|
70 |
|
|
|
|
|
|
|
|
|
|
K
|
G
|
I
|
Y
|
L
|
K
|
E
|
E
|
K
|
G
|
80 |
|
|
|
|
|
|
|
|
|
|
V
|
T
|
L
|
L
|
Y
|
Y
|
G
|
R
|
Y
|
N
|
90 |
|
|
|
|
|
|
|
|
|
|
S
|
S
|
C
|
I
|
S
|
K
|
P
|
E
|
Q
|
C
|
100 |
|
|
|
|
|
|
|
|
|
|
G
|
P
|
E
|
G
|
V
|
T
|
F
|
S
|
F
|
F
|
110 |
|
|
|
|
|
|
|
|
|
|
W
|
K
|
T
|
Q
|
G
|
E
|
Q
|
S
|
R
|
P
|
120 |
|
|
|
|
|
|
|
|
|
|
I
|
P
|
S
|
A
|
Y
|
G
|
G
|
Q
|
V
|
I
|
130 |
|
|
|
|
|
|
|
|
|
|
S
|
N
|
G
|
F
|
K
|
V
|
C
|
S
|
S
|
G
|
140 |
|
|
|
|
|
|
|
|
|
|
G
|
R
|
G
|
S
|
V
|
E
|
L
|
Y
|
T
|
R
|
150 |
|
|
|
|
|
|
|
|
|
|
D
|
N
|
S
|
M
|
T
|
W
|
E
|
A
|
S
|
F
|
160 |
|
|
|
|
|
|
|
|
|
|
S
|
P
|
P
|
G
|
P
|
Y
|
W
|
T
|
H
|
V
|
170 |
|
|
|
|
|
|
|
|
|
|
L
|
F
|
T
|
W
|
K
|
S
|
K
|
E
|
G
|
L
|
180 |
|
|
|
|
|
|
|
|
|
|
K
|
V
|
Y
|
V
|
N
|
G
|
T
|
L
|
S
|
T
|
190 |
|
|
|
|
|
|
|
|
|
|
S
|
D
|
P
|
S
|
G
|
K
|
V
|
S
|
R
|
D
|
200 |
|
|
|
|
|
|
|
|
|
|
Y
|
G
|
E
|
S
|
N
|
V
|
N
|
L
|
V
|
I
|
210 |
|
|
|
|
|
|
|
|
|
|
G
|
S
|
E
|
Q
|
D
|
Q
|
A
|
K
|
C
|
Y
|
220 |
|
|
|
|
|
|
|
|
|
|
E
|
N
|
G
|
A
|
F
|
D
|
E
|
F
|
I
|
I
|
230 |
|
|
|
|
|
|
|
|
|
|
W
|
E
|
R
|
A
|
L
|
T
|
P
|
D
|
E
|
I
|
240 |
|
|
|
|
|
|
|
|
|
|
A
|
M
|
Y
|
F
|
T
|
A
|
A
|
I
|
G
|
K
|
250 |
|
|
|
|
|
|
|
|
|
|
H
|
A
|
L
|
L
|
S
|
S
|
T
|
L
|
P
|
S
|
260 |
|
|
|
|
|
|
|
|
|
|
L
|
F
|
M
|
T
|
S
|
T
|
A
|
S
|
P
|
V
|
270 |
|
|
|
|
|
|
|
|
|
|
M
|
P
|
T
|
D
|
A
|
Y
|
H
|
P
|
I
|
I
|
280 |
|
|
|
|
|
|
|
|
|
|
T
|
N
|
L
|
T
|
E
|
E
|
R
|
K
|
T
|
F
|
290 |
|
|
|
|
|
|
|
|
|
|
Q
|
S
|
P
|
G
|
V
|
I
|
L
|
S
|
Y
|
L
|
300 |
|
|
|
|
|
|
|
|
|
|
Q
|
N
|
V
|
S
|
L
|
S
|
L
|
P
|
S
|
K
|
310 |
|
|
|
|
|
|
|
|
|
|
S
|
L
|
S
|
E
|
Q
|
T
|
A
|
L
|
N
|
L
|
320 |
|
|
|
|
|
|
|
|
|
|
T
|
K
|
T
|
F
|
L
|
K
|
A
|
V
|
G
|
E
|
330 |
|
|
|
|
|
|
|
|
|
|
I
|
L
|
L
|
L
|
P
|
G
|
W
|
I
|
A
|
L
|
340 |
|
|
|
|
|
|
|
|
|
|
S
|
E
|
D
|
S
|
A
|
V
|
V
|
L
|
S
|
L
|
350 |
|
|
|
|
|
|
|
|
|
|
I
|
D
|
T
|
I
|
D
|
T
|
V
|
M
|
G
|
H
|
360 |
|
|
|
|
|
|
|
|
|
|
V
|
S
|
S
|
N
|
L
|
H
|
G
|
S
|
T
|
P
|
370 |
|
|
|
|
|
|
|
|
|
|
Q
|
V
|
T
|
V
|
E
|
G
|
S
|
S
|
A
|
M
|
380 |
|
|
|
|
|
|
|
|
|
|
A
|
E
|
F
|
S
|
V
|
A
|
K
|
I
|
L
|
P
|
390 |
|
|
|
|
|
|
|
|
|
|
K
|
T
|
V
|
N
|
S
|
S
|
H
|
Y
|
R
|
F
|
400 |
|
|
|
|
|
|
|
|
|
|
P
|
A
|
H
|
G
|
Q
|
S
|
F
|
I
|
Q
|
I
|
410 |
|
|
|
|
|
|
|
|
|
|
P
|
H
|
E
|
A
|
F
|
H
|
R
|
H
|
A
|
W
|
420 |
|
|
|
|
|
|
|
|
|
|
S
|
T
|
V
|
V
|
G
|
L
|
L
|
Y
|
H
|
S
|
430 |
|
|
|
|
|
|
|
|
|
|
M
|
H
|
Y
|
Y
|
L
|
N
|
N
|
I
|
W
|
P
|
440 |
|
|
|
|
|
|
|
|
|
|
A
|
H
|
T
|
K
|
I
|
A
|
E
|
A
|
M
|
H
|
450 |
|
|
|
|
|
|
|
|
|
|
H
|
Q
|
D
|
C
|
L
|
L
|
F
|
A
|
T
|
S
|
460 |
|
|
|
|
|
|
|
|
|
|
H
|
L
|
I
|
S
|
L
|
E
|
V
|
S
|
P
|
P
|
470 |
|
|
|
|
|
|
|
|
|
|
P
|
T
|
L
|
S
|
Q
|
N
|
L
|
S
|
G
|
S
|
480 |
|
|
|
|
|
|
|
|
|
|
P
|
L
|
I
|
T
|
V
|
H
|
L
|
K
|
H
|
R
|
490 |
|
|
|
|
|
|
|
|
|
|
L
|
T
|
R
|
K
|
Q
|
H
|
S
|
E
|
A
|
T
|
500 |
|
|
|
|
|
|
|
|
|
|
N
|
S
|
S
|
N
|
R
|
V
|
F
|
V
|
Y
|
C
|
510 |
|
|
|
|
|
|
|
|
|
|
A
|
F
|
L
|
D
|
F
|
S
|
S
|
G
|
E
|
G
|
520 |
|
|
|
|
|
|
|
|
|
|
V
|
W
|
S
|
N
|
H
|
G
|
C
|
A
|
L
|
T
|
530 |
|
|
|
|
|
|
|
|
|
|
R
|
G
|
N
|
L
|
T
|
Y
|
S
|
V
|
C
|
R
|
540 |
|
|
|
|
||||||
C
|
T
|
H
|
L
|
T
|
N
|
F
|
A
|
I
|
L
|
550 |
M
|
Q
|
V
|
V
|
P
|
L
|
E
|
L
|
A
|
R
|
560 |
TM1 | |||||||||
G
|
H
|
Q
|
V
|
A
|
L
|
S
|
S
|
I
|
S
|
570 |
Y
|
V
|
G
|
C
|
S
|
L
|
S
|
V
|
L
|
C
|
580 |
L
|
V
|
A
|
T
|
L
|
V
|
T
|
F
|
A
|
V
|
590 |
ICL1 | |||||||||
L
|
S
|
S
|
V
|
S
|
T
|
I
|
R
|
N
|
Q
|
600 |
TM2 | |||||||||
R
|
Y
|
H
|
I
|
H
|
A
|
N
|
L
|
S
|
F
|
610 |
A
|
V
|
L
|
V
|
A
|
Q
|
V
|
L
|
L
|
L
|
620 |
ECL1 | |||||||||
I
|
S
|
F
|
R
|
L
|
E
|
P
|
G
|
T
|
T
|
630 |
TM3 | |||||||||
P
|
C
|
Q
|
V
|
M
|
A
|
V
|
L
|
L
|
H
|
640 |
Y
|
F
|
F
|
L
|
S
|
A
|
F
|
A
|
W
|
M
|
650 |
L
|
V
|
E
|
G
|
L
|
H
|
L
|
Y
|
S
|
M
|
660 |
ICL2 | |||||||||
V
|
I
|
K
|
V
|
F
|
G
|
S
|
E
|
D
|
S
|
670 |
TM4 | |||||||||
K
|
H
|
R
|
Y
|
Y
|
Y
|
G
|
M
|
G
|
W
|
680 |
G
|
F
|
P
|
L
|
L
|
I
|
C
|
I
|
I
|
S
|
690 |
ECL2 | |||||||||
L
|
S
|
F
|
A
|
M
|
D
|
S
|
Y
|
G
|
T
|
700 |
S
|
N
|
N
|
C
|
W
|
L
|
S
|
L
|
A
|
S
|
710 |
TM5 | |||||||||
G
|
A
|
I
|
W
|
A
|
F
|
V
|
A
|
P
|
A
|
720 |
L
|
F
|
V
|
I
|
V
|
V
|
N
|
I
|
G
|
I
|
730 |
L
|
I
|
A
|
V
|
T
|
R
|
V
|
I
|
S
|
Q
|
740 |
I
|
S
|
A
|
D
|
N
|
Y
|
K
|
I
|
H
|
G
|
750 |
TM6 | |||||||||
D
|
P
|
S
|
A
|
F
|
K
|
L
|
T
|
A
|
K
|
760 |
A
|
V
|
A
|
V
|
L
|
L
|
P
|
I
|
L
|
G
|
770 |
T
|
S
|
W
|
V
|
F
|
G
|
V
|
L
|
A
|
V
|
780 |
ECL3 | TM7 | ||||||||
N
|
G
|
C
|
A
|
V
|
V
|
F
|
Q
|
Y
|
M
|
790 |
F
|
A
|
T
|
L
|
N
|
S
|
L
|
Q
|
G
|
L
|
800 |
F
|
I
|
F
|
L
|
F
|
H
|
C
|
L
|
L
|
N
|
810 |
H8 | |||||||||
S
|
E
|
V
|
R
|
A
|
A
|
F
|
K
|
H
|
K
|
820 |
|
|
|
|||||||
T
|
K
|
V
|
W
|
S
|
L
|
T
|
S
|
S
|
S
|
830 |
|
|
|
|
|
|
|
|
|
|
C-term | |||||||||
A
|
R
|
T
|
S
|
N
|
A
|
K
|
P
|
F
|
H
|
840 |
|
|
|
|
|
|
|
|
|
|
S
|
D
|
L
|
M
|
N
|
G
|
T
|
R
|
P
|
G
|
850 |
|
|
|
|
|
|
|
|
|
|
M
|
A
|
S
|
T
|
K
|
L
|
S
|
P
|
W
|
D
|
860 |
|
|
|
|
|
|
|
|
|
|
K
|
S
|
S
|
H
|
S
|
A
|
H
|
R
|
V
|
D
|
870 |
|
|
|
|
L
|
S
|
A
|
V
|
|
|||||||||
N-term | |||||||||
|
T
|
N
|
F
|
A
|
I
|
L
|
M
|
Q
|
V
|
553 |
TM1 | |||||||||
V
|
P
|
L
|
E
|
L
|
A
|
R
|
G
|
H
|
Q
|
563 |
V
|
A
|
L
|
S
|
S
|
I
|
S
|
Y
|
V
|
G
|
573 |
C
|
S
|
L
|
S
|
V
|
L
|
C
|
L
|
V
|
A
|
583 |
T
|
L
|
V
|
T
|
F
|
A
|
V
|
L
|
S
|
S
|
593 |
ICL1 | TM2 | ||||||||
V
|
S
|
T
|
I
|
R
|
N
|
Q
|
R
|
Y
|
H
|
603 |
I
|
H
|
A
|
N
|
L
|
S
|
F
|
A
|
V
|
L
|
613 |
V
|
A
|
Q
|
V
|
L
|
L
|
L
|
I
|
S
|
F
|
623 |
ECL1 | TM3 | ||||||||
R
|
L
|
E
|
P
|
G
|
T
|
T
|
P
|
C
|
Q
|
633 |
V
|
M
|
A
|
V
|
L
|
L
|
H
|
Y
|
F
|
F
|
643 |
L
|
S
|
A
|
F
|
A
|
W
|
M
|
L
|
V
|
E
|
653 |
G
|
L
|
H
|
L
|
Y
|
S
|
M
|
V
|
I
|
K
|
663 |
ICL2 | TM4 | ||||||||
V
|
F
|
G
|
S
|
E
|
D
|
S
|
K
|
H
|
R
|
673 |
Y
|
Y
|
Y
|
G
|
M
|
G
|
W
|
G
|
F
|
P
|
683 |
L
|
L
|
I
|
C
|
I
|
I
|
S
|
L
|
S
|
F
|
693 |
ECL2 | |||||||||
A
|
M
|
D
|
S
|
Y
|
G
|
T
|
S
|
N
|
N
|
703 |
TM5 | |||||||||
C
|
W
|
L
|
S
|
L
|
A
|
S
|
G
|
A
|
I
|
713 |
W
|
A
|
F
|
V
|
A
|
P
|
A
|
L
|
F
|
V
|
723 |
I
|
V
|
V
|
N
|
I
|
G
|
I
|
L
|
I
|
A
|
733 |
V
|
T
|
R
|
V
|
I
|
S
|
Q
|
I
|
S
|
A
|
743 |
ICL3 | TM6 | |||||||||
D
|
N
|
Y
|
K
|
I
|
H
|
G
|
D
|
P
|
S
|
|
753 |
A
|
F
|
K
|
L
|
T
|
A
|
K
|
A
|
V
|
A
|
763 |
V
|
L
|
L
|
P
|
I
|
L
|
G
|
T
|
S
|
W
|
773 |
V
|
F
|
G
|
V
|
L
|
A
|
V
|
N
|
G
|
C
|
783 |
TM7 | |||||||||
A
|
V
|
V
|
F
|
Q
|
Y
|
M
|
F
|
A
|
T
|
793 |
L
|
N
|
S
|
L
|
Q
|
G
|
L
|
F
|
I
|
F
|
803 |
H8 | |||||||||
L
|
F
|
H
|
C
|
L
|
L
|
N
|
S
|
E
|
V
|
813 |
R
|
A
|
A
|
F
|
K
|
H
|
K
|
T
|
K
|
V
|
823 |
|
||||||||
C-term | ||||||||
W
|
S
|
L
|
T
|
|
||||
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|