oprk_human
NAME
7YIT
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
oprk_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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D
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S
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P
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I
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Q
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I
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F
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R
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G
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10 |
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|
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|
|
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E
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P
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G
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P
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T
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C
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A
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P
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S
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A
|
20 |
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|
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|
|
|
|
|
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C
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L
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P
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P
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N
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S
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S
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A
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W
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F
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30 |
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|
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|
|
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P
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G
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W
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A
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E
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P
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D
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S
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N
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G
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40 |
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|
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S
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A
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G
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S
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E
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D
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A
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Q
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L
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E
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50 |
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|||||||
TM1 | |||||||||
P
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A
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H
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I
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S
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P
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A
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I
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P
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V
|
60 |
I
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I
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T
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A
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V
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Y
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S
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V
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V
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F
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70 |
V
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V
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G
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L
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V
|
G
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N
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S
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L
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V
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80 |
M
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F
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V
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I
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I
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R
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Y
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T
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K
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M
|
90 |
ICL1 | TM2 | ||||||||
K
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T
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A
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T
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N
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I
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Y
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I
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F
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N
|
100 |
L
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A
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L
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A
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D
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A
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L
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V
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T
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T
|
110 |
T
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M
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P
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F
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Q
|
S
|
T
|
V
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Y
|
L
|
120 |
ECL1 | TM3 | ||||||||
M
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N
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S
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W
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P
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F
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G
|
D
|
V
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L
|
130 |
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|||||||||
C
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K
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I
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V
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I
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S
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I
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D
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Y
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Y
|
140 |
N
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M
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F
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T
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S
|
I
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F
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T
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L
|
T
|
150 |
M
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M
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S
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V
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D
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R
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Y
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I
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A
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V
|
160 |
ICL2 | |||||||||
C
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H
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P
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V
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K
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A
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L
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D
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F
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R
|
170 |
TM4 | |||||||||
T
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P
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L
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K
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A
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K
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I
|
I
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N
|
I
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180 |
C
|
I
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W
|
L
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L
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S
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S
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S
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V
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G
|
190 |
I
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S
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A
|
I
|
V
|
L
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G
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G
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T
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K
|
200 |
ECL2 | |||||||||
V
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R
|
E
|
D
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V
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D
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V
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I
|
E
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C
|
210 |
TM5 | |||||||||
S
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L
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Q
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F
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P
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D
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D
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D
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Y
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S
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220 |
W
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W
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D
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L
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F
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M
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K
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I
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C
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V
|
230 |
F
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I
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F
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A
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F
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V
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I
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P
|
V
|
L
|
240 |
I
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I
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I
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V
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C
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Y
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T
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L
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M
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I
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250 |
ICL3 | |||||||||
L
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R
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L
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K
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S
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V
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R
|
L
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L
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S
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260 |
TM6 | |||||||||
G
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S
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R
|
E
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K
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D
|
R
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N
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L
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R
|
270 |
R
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I
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T
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R
|
L
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V
|
L
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V
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V
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V
|
280 |
A
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V
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F
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V
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V
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C
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W
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T
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P
|
I
|
290 |
H
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I
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F
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I
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L
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V
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E
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A
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L
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G
|
300 |
ECL3 | TM7 | ||||||||
S
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T
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S
|
H
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S
|
T
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A
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A
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L
|
S
|
310 |
S
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Y
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Y
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F
|
C
|
I
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A
|
L
|
G
|
Y
|
320 |
T
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N
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S
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S
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L
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N
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P
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I
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L
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Y
|
330 |
H8 | |||||||||
A
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F
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L
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D
|
E
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N
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F
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K
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R
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C
|
340 |
F
|
R
|
D
|
F
|
C
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F
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P
|
L
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K
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M
|
350 |
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||||||||
C-term | |||||||||
R
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M
|
E
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R
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Q
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S
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T
|
S
|
R
|
V
|
360 |
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|
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|
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|
|
|
R
|
N
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T
|
V
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Q
|
D
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P
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A
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Y
|
L
|
370 |
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|
|
|
|
|
|
|
R
|
D
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I
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D
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G
|
M
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N
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K
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P
|
V
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380 |
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|||||||||
N-term | TM1 | ||||||||
|
I
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S
|
P
|
A
|
I
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P
|
V
|
I
|
I
|
62 |
T
|
A
|
V
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Y
|
S
|
V
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V
|
F
|
V
|
V
|
72 |
G
|
L
|
V
|
G
|
N
|
S
|
L
|
V
|
M
|
F
|
82 |
ICL1 | |||||||||
V
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I
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I
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R
|
Y
|
T
|
K
|
M
|
K
|
T
|
92 |
TM2 | |||||||||
A
|
T
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N
|
I
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Y
|
I
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F
|
N
|
L
|
A
|
102 |
L
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A
|
D
|
A
|
L
|
V
|
T
|
T
|
T
|
M
|
112 |
P
|
F
|
Q
|
S
|
T
|
V
|
Y
|
L
|
M
|
N
|
122 |
ECL1 | TM3 | ||||||||
S
|
W
|
P
|
F
|
G
|
D
|
V
|
L
|
C
|
K
|
132 |
|
|||||||||
I
|
V
|
L
|
S
|
I
|
D
|
Y
|
Y
|
N
|
M
|
142 |
F
|
T
|
S
|
I
|
F
|
T
|
L
|
T
|
M
|
M
|
152 |
S
|
V
|
D
|
R
|
Y
|
I
|
A
|
V
|
C
|
H
|
162 |
ICL2 | |||||||||
P
|
V
|
K
|
A
|
L
|
D
|
F
|
R
|
T
|
P
|
172 |
TM4 | |||||||||
L
|
K
|
A
|
K
|
I
|
I
|
N
|
I
|
C
|
I
|
182 |
W
|
L
|
L
|
S
|
S
|
S
|
V
|
G
|
I
|
S
|
192 |
ECL2 | |||||||||
A
|
I
|
V
|
L
|
G
|
G
|
T
|
K
|
V
|
R
|
202 |
E
|
D
|
V
|
D
|
V
|
I
|
E
|
C
|
S
|
L
|
212 |
TM5 | |||||||||
Q
|
F
|
P
|
D
|
D
|
D
|
Y
|
S
|
W
|
W
|
222 |
D
|
L
|
F
|
M
|
K
|
I
|
C
|
V
|
F
|
I
|
232 |
F
|
A
|
F
|
V
|
I
|
P
|
V
|
L
|
I
|
I
|
242 |
I
|
V
|
C
|
Y
|
T
|
L
|
M
|
I
|
L
|
R
|
252 |
ICL3 | |||||||||
L
|
K
|
S
|
V
|
R
|
L
|
L
|
S
|
G
|
S
|
262 |
TM6 | |||||||||
R
|
E
|
K
|
D
|
R
|
N
|
L
|
R
|
R
|
I
|
272 |
T
|
R
|
L
|
V
|
L
|
V
|
V
|
V
|
A
|
V
|
282 |
F
|
V
|
V
|
C
|
W
|
T
|
P
|
I
|
H
|
I
|
292 |
F
|
I
|
L
|
V
|
E
|
A
|
L
|
G
|
S
|
T
|
302 |
ECL3 | TM7 | ||||||||
S
|
H
|
S
|
T
|
A
|
A
|
L
|
S
|
S
|
Y
|
312 |
Y
|
F
|
C
|
I
|
A
|
L
|
G
|
Y
|
T
|
N
|
322 |
S
|
S
|
L
|
N
|
P
|
I
|
L
|
Y
|
A
|
F
|
332 |
H8 | |||||||||
L
|
D
|
E
|
N
|
F
|
K
|
R
|
C
|
F
|
R
|
342 |
C-term | |||||||||
D
|
F
|
C
|
F
|
P
|
L
|
K
|
M
|
R
|
M
|
352 |
|
||||||
E
|
R
|
Q
|
S
|
T
|
S
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|---|---|
135 | | I | L |
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|