s1pr5_human
NAME
7YXA
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
s1pr5_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
N-term | |||||||||
M
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E
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S
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G
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L
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L
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R
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P
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A
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P
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10 |
V
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S
|
E
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V
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I
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V
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L
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H
|
Y
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N
|
20 |
Y
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T
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G
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K
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L
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R
|
G
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A
|
R
|
Y
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30 |
TM1 | |||||||||
Q
|
P
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G
|
A
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G
|
L
|
R
|
A
|
D
|
A
|
40 |
V
|
V
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C
|
L
|
A
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V
|
C
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A
|
F
|
I
|
50 |
V
|
L
|
E
|
N
|
L
|
A
|
V
|
L
|
L
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V
|
60 |
ICL1 | |||||||||
L
|
G
|
R
|
H
|
P
|
R
|
F
|
H
|
A
|
P
|
70 |
TM2 | |||||||||
M
|
F
|
L
|
L
|
L
|
G
|
S
|
L
|
T
|
L
|
80 |
S
|
D
|
L
|
L
|
A
|
G
|
A
|
A
|
Y
|
A
|
90 |
ECL1 | |||||||||
A
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N
|
I
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L
|
L
|
S
|
G
|
P
|
L
|
T
|
100 |
TM3 | |||||||||
L
|
K
|
L
|
S
|
P
|
A
|
L
|
W
|
F
|
A
|
110 |
R
|
E
|
G
|
G
|
V
|
F
|
V
|
A
|
L
|
T
|
120 |
A
|
S
|
V
|
L
|
S
|
L
|
L
|
A
|
I
|
A
|
130 |
L
|
E
|
R
|
S
|
L
|
T
|
M
|
A
|
R
|
R
|
140 |
ICL2 | TM4 | ||||||||
G
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P
|
A
|
P
|
V
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S
|
S
|
R
|
G
|
R
|
150 |
T
|
L
|
A
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M
|
A
|
A
|
A
|
A
|
W
|
G
|
160 |
V
|
S
|
L
|
L
|
L
|
G
|
L
|
L
|
P
|
A
|
170 |
ECL2 | |||||||||
L
|
G
|
W
|
N
|
C
|
L
|
G
|
R
|
L
|
D
|
180 |
A
|
C
|
S
|
T
|
V
|
L
|
P
|
L
|
Y
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A
|
190 |
TM5 | |||||||||
K
|
A
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Y
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V
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L
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F
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C
|
V
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L
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A
|
200 |
F
|
V
|
G
|
I
|
L
|
A
|
A
|
I
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C
|
A
|
210 |
L
|
Y
|
A
|
R
|
I
|
Y
|
C
|
Q
|
V
|
R
|
220 |
|
|
|
|
|
|
|
|||
A
|
N
|
A
|
R
|
R
|
L
|
P
|
A
|
R
|
P
|
230 |
|
|
|
|
|
|
|
|
|
|
ICL3 | |||||||||
G
|
T
|
A
|
G
|
T
|
T
|
S
|
T
|
R
|
A
|
240 |
TM6 | |||||||||
R
|
R
|
K
|
P
|
R
|
S
|
L
|
A
|
L
|
L
|
250 |
R
|
T
|
L
|
S
|
V
|
V
|
L
|
L
|
A
|
F
|
260 |
V
|
A
|
C
|
W
|
G
|
P
|
L
|
F
|
L
|
L
|
270 |
L
|
L
|
L
|
D
|
V
|
A
|
C
|
P
|
A
|
R
|
280 |
ECL3 | TM7 | ||||||||
T
|
C
|
P
|
V
|
L
|
L
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Q
|
A
|
D
|
P
|
290 |
F
|
L
|
G
|
L
|
A
|
M
|
A
|
N
|
S
|
L
|
300 |
L
|
N
|
P
|
I
|
I
|
Y
|
T
|
L
|
T
|
N
|
310 |
H8 | |||||||||
R
|
D
|
L
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R
|
H
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A
|
L
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L
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R
|
L
|
320 |
|
|
|
|
|
|
|
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|
|
C-term | |||||||||
V
|
C
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C
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G
|
R
|
H
|
S
|
C
|
G
|
R
|
330 |
|
|
|
|
|
|
|
|
|
|
D
|
P
|
S
|
G
|
S
|
Q
|
Q
|
S
|
A
|
S
|
340 |
|
|
|
|
|
|
|
|
|
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A
|
A
|
E
|
A
|
S
|
G
|
G
|
L
|
R
|
R
|
350 |
|
|
|
|
|
|
|
|
|
|
C
|
L
|
P
|
P
|
G
|
L
|
D
|
G
|
S
|
F
|
360 |
|
|
|
|
|
|
|
|
|
|
S
|
G
|
S
|
E
|
R
|
S
|
S
|
P
|
Q
|
R
|
370 |
|
|
|
|
|
|
|
|
|
|
D
|
G
|
L
|
D
|
T
|
S
|
G
|
S
|
T
|
G
|
380 |
|
|
|
|
|
|
|
|
|
|
S
|
P
|
G
|
A
|
P
|
T
|
A
|
A
|
R
|
T
|
390 |
|
|
|
|
|
|
|
|
L
|
V
|
S
|
E
|
P
|
A
|
A
|
D
|
N-term | |||||||||
M
|
E
|
S
|
G
|
L
|
L
|
R
|
P
|
A
|
P
|
10 |
V
|
S
|
E
|
V
|
I
|
V
|
L
|
H
|
Y
|
N
|
20 |
Y
|
T
|
G
|
K
|
L
|
R
|
G
|
A
|
R
|
Y
|
30 |
TM1 | |||||||||
Q
|
P
|
G
|
A
|
G
|
L
|
R
|
A
|
D
|
A
|
40 |
V
|
V
|
C
|
L
|
A
|
V
|
C
|
A
|
F
|
I
|
50 |
V
|
L
|
E
|
N
|
L
|
A
|
V
|
L
|
L
|
V
|
60 |
ICL1 | |||||||||
L
|
G
|
R
|
H
|
P
|
R
|
F
|
H
|
A
|
P
|
70 |
TM2 | |||||||||
M
|
F
|
L
|
L
|
L
|
G
|
S
|
L
|
T
|
L
|
80 |
S
|
D
|
L
|
L
|
A
|
G
|
A
|
A
|
Y
|
A
|
90 |
ECL1 | |||||||||
A
|
N
|
I
|
L
|
L
|
S
|
G
|
P
|
L
|
T
|
100 |
TM3 | |||||||||
L
|
K
|
L
|
S
|
P
|
A
|
L
|
W
|
F
|
A
|
110 |
R
|
E
|
G
|
G
|
V
|
F
|
V
|
A
|
L
|
T
|
120 |
A
|
S
|
V
|
L
|
S
|
L
|
L
|
A
|
I
|
A
|
130 |
L
|
E
|
R
|
S
|
L
|
T
|
M
|
A
|
R
|
R
|
140 |
ICL2 | TM4 | ||||||||
G
|
P
|
A
|
P
|
V
|
S
|
S
|
R
|
G
|
R
|
150 |
T
|
L
|
A
|
M
|
A
|
A
|
A
|
A
|
W
|
G
|
160 |
V
|
S
|
L
|
L
|
L
|
G
|
L
|
L
|
P
|
A
|
170 |
ECL2 | |||||||||
L
|
G
|
W
|
N
|
C
|
L
|
G
|
R
|
L
|
D
|
180 |
A
|
C
|
S
|
T
|
V
|
L
|
P
|
L
|
Y
|
A
|
190 |
TM5 | |||||||||
K
|
A
|
Y
|
V
|
L
|
F
|
C
|
V
|
L
|
A
|
200 |
F
|
V
|
G
|
I
|
L
|
A
|
A
|
I
|
C
|
A
|
210 |
L
|
Y
|
A
|
R
|
I
|
Y
|
C
|
Q
|
V
|
R
|
220 |
|
|||||||||
TM6 | |||||||||
A
|
N
|
A
|
|
R
|
R
|
K
|
P
|
R
|
S
|
246 |
L
|
A
|
L
|
L
|
R
|
T
|
L
|
S
|
V
|
V
|
256 |
L
|
L
|
A
|
F
|
V
|
A
|
C
|
W
|
G
|
P
|
266 |
L
|
F
|
L
|
L
|
L
|
L
|
L
|
D
|
V
|
A
|
276 |
ECL3 | TM7 | ||||||||
C
|
P
|
A
|
R
|
T
|
C
|
P
|
V
|
L
|
L
|
286 |
Q
|
A
|
D
|
P
|
F
|
L
|
G
|
L
|
A
|
M
|
296 |
A
|
N
|
S
|
L
|
L
|
N
|
P
|
I
|
I
|
Y
|
306 |
H8 | |||||||||
T
|
L
|
T
|
N
|
R
|
D
|
L
|
R
|
H
|
A
|
316 |
|
|||||
L
|
L
|
R
|
L
|
V
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|