aa2ar_human
NAME
8GNE
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
aa2ar_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
|
|||||||||
TM1 | |||||||||
M
|
P
|
I
|
M
|
G
|
S
|
S
|
V
|
Y
|
I
|
10 |
T
|
V
|
E
|
L
|
A
|
I
|
A
|
V
|
L
|
A
|
20 |
I
|
L
|
G
|
N
|
V
|
L
|
V
|
C
|
W
|
A
|
30 |
ICL1 | |||||||||
V
|
W
|
L
|
N
|
S
|
N
|
L
|
Q
|
N
|
V
|
40 |
TM2 | |||||||||
T
|
N
|
Y
|
F
|
V
|
V
|
S
|
L
|
A
|
A
|
50 |
A
|
D
|
I
|
A
|
V
|
G
|
V
|
L
|
A
|
I
|
60 |
P
|
F
|
A
|
I
|
T
|
I
|
S
|
T
|
G
|
F
|
70 |
ECL1 | TM3 | ||||||||
C
|
A
|
A
|
C
|
H
|
G
|
C
|
L
|
F
|
I
|
80 |
A
|
C
|
F
|
V
|
L
|
V
|
L
|
T
|
Q
|
S
|
90 |
S
|
I
|
F
|
S
|
L
|
L
|
A
|
I
|
A
|
I
|
100 |
D
|
R
|
Y
|
I
|
A
|
I
|
R
|
I
|
P
|
L
|
110 |
ICL2 | TM4 | ||||||||
R
|
Y
|
N
|
G
|
L
|
V
|
T
|
G
|
T
|
R
|
120 |
A
|
K
|
G
|
I
|
I
|
A
|
I
|
C
|
W
|
V
|
130 |
L
|
S
|
F
|
A
|
I
|
G
|
L
|
T
|
P
|
M
|
140 |
ECL2 | |||||||||
L
|
G
|
W
|
N
|
N
|
C
|
G
|
Q
|
P
|
K
|
150 |
E
|
G
|
K
|
N
|
H
|
S
|
Q
|
G
|
C
|
G
|
160 |
E
|
G
|
Q
|
V
|
A
|
C
|
L
|
F
|
E
|
D
|
170 |
TM5 | |||||||||
V
|
V
|
P
|
M
|
N
|
Y
|
M
|
V
|
Y
|
F
|
180 |
N
|
F
|
F
|
A
|
C
|
V
|
L
|
V
|
P
|
L
|
190 |
L
|
L
|
M
|
L
|
G
|
V
|
Y
|
L
|
R
|
I
|
200 |
|
|
||||||||
F
|
L
|
A
|
A
|
R
|
R
|
Q
|
L
|
K
|
Q
|
210 |
|
|
|
|
|
|
|
|
||
ICL3 | |||||||||
M
|
E
|
S
|
Q
|
P
|
L
|
P
|
G
|
E
|
R
|
220 |
TM6 | |||||||||
A
|
R
|
S
|
T
|
L
|
Q
|
K
|
E
|
V
|
H
|
230 |
A
|
A
|
K
|
S
|
L
|
A
|
I
|
I
|
V
|
G
|
240 |
L
|
F
|
A
|
L
|
C
|
W
|
L
|
P
|
L
|
H
|
250 |
I
|
I
|
N
|
C
|
F
|
T
|
F
|
F
|
C
|
P
|
260 |
ECL3 | TM7 | ||||||||
D
|
C
|
S
|
H
|
A
|
P
|
L
|
W
|
L
|
M
|
270 |
Y
|
L
|
A
|
I
|
V
|
L
|
S
|
H
|
T
|
N
|
280 |
S
|
V
|
V
|
N
|
P
|
F
|
I
|
Y
|
A
|
Y
|
290 |
H8 | |||||||||
R
|
I
|
R
|
E
|
F
|
R
|
Q
|
T
|
F
|
R
|
300 |
K
|
I
|
I
|
R
|
S
|
H
|
V
|
L
|
R
|
Q
|
310 |
|
|
|
|
||||||
C-term | |||||||||
Q
|
E
|
P
|
F
|
K
|
A
|
A
|
G
|
T
|
S
|
320 |
|
|
|
|
|
|
|
|
|
|
A
|
R
|
V
|
L
|
A
|
A
|
H
|
G
|
S
|
D
|
330 |
|
|
|
|
|
|
|
|
|
|
G
|
E
|
Q
|
V
|
S
|
L
|
R
|
L
|
N
|
G
|
340 |
|
|
|
|
|
|
|
|
|
|
H
|
P
|
P
|
G
|
V
|
W
|
A
|
N
|
G
|
S
|
350 |
|
|
|
|
|
|
|
|
|
|
A
|
P
|
H
|
P
|
E
|
R
|
R
|
P
|
N
|
G
|
360 |
|
|
|
|
|
|
|
|
|
|
Y
|
A
|
L
|
G
|
L
|
V
|
S
|
G
|
G
|
S
|
370 |
|
|
|
|
|
|
|
|
|
|
A
|
Q
|
E
|
S
|
Q
|
G
|
N
|
T
|
G
|
L
|
380 |
|
|
|
|
|
|
|
|
|
|
P
|
D
|
V
|
E
|
L
|
L
|
S
|
H
|
E
|
L
|
390 |
|
|
|
|
|
|
|
|
|
|
K
|
G
|
V
|
C
|
P
|
E
|
P
|
P
|
G
|
L
|
400 |
|
|
|
|
|
|
|
|
|
|
D
|
D
|
P
|
L
|
A
|
Q
|
D
|
G
|
A
|
G
|
410 |
|
|
V
|
S
|
|
|||||||||
TM1 | |||||||||
|
P
|
I
|
M
|
G
|
S
|
S
|
V
|
Y
|
I
|
10 |
T
|
V
|
E
|
L
|
A
|
I
|
A
|
V
|
L
|
A
|
20 |
I
|
L
|
G
|
N
|
V
|
L
|
V
|
C
|
W
|
A
|
30 |
ICL1 | |||||||||
V
|
W
|
L
|
N
|
S
|
N
|
L
|
Q
|
N
|
V
|
40 |
TM2 | |||||||||
T
|
N
|
Y
|
F
|
V
|
V
|
S
|
L
|
A
|
A
|
50 |
A
|
D
|
I
|
A
|
V
|
G
|
V
|
L
|
A
|
I
|
60 |
P
|
F
|
A
|
I
|
T
|
I
|
S
|
T
|
G
|
F
|
70 |
ECL1 | TM3 | ||||||||
C
|
A
|
A
|
C
|
H
|
G
|
C
|
L
|
F
|
I
|
80 |
A
|
C
|
F
|
V
|
L
|
V
|
L
|
T
|
Q
|
S
|
90 |
S
|
I
|
F
|
S
|
L
|
L
|
A
|
I
|
A
|
I
|
100 |
D
|
R
|
Y
|
I
|
A
|
I
|
R
|
I
|
P
|
L
|
110 |
ICL2 | TM4 | ||||||||
R
|
Y
|
N
|
G
|
L
|
V
|
T
|
G
|
T
|
R
|
120 |
A
|
K
|
G
|
I
|
I
|
A
|
I
|
C
|
W
|
V
|
130 |
L
|
S
|
F
|
A
|
I
|
G
|
L
|
T
|
P
|
M
|
140 |
ECL2 | |||||||||
L
|
G
|
W
|
N
|
N
|
C
|
G
|
Q
|
P
|
K
|
150 |
E
|
G
|
K
|
N
|
H
|
S
|
Q
|
G
|
C
|
G
|
160 |
E
|
G
|
Q
|
V
|
A
|
C
|
L
|
F
|
E
|
D
|
170 |
TM5 | |||||||||
V
|
V
|
P
|
M
|
N
|
Y
|
M
|
V
|
Y
|
F
|
180 |
N
|
F
|
F
|
A
|
C
|
V
|
L
|
V
|
P
|
L
|
190 |
L
|
L
|
M
|
L
|
G
|
V
|
Y
|
L
|
R
|
I
|
200 |
|
|||||||||
F
|
L
|
A
|
A
|
R
|
R
|
Q
|
L
|
|
E
|
219 |
TM6 | |||||||||
R
|
A
|
R
|
S
|
T
|
L
|
Q
|
K
|
E
|
V
|
229 |
H
|
A
|
A
|
K
|
S
|
L
|
A
|
I
|
I
|
V
|
239 |
G
|
L
|
F
|
A
|
L
|
C
|
W
|
L
|
P
|
L
|
249 |
H
|
I
|
I
|
N
|
C
|
F
|
T
|
F
|
F
|
C
|
259 |
ECL3 | TM7 | ||||||||
P
|
D
|
C
|
S
|
H
|
A
|
P
|
L
|
W
|
L
|
269 |
M
|
Y
|
L
|
A
|
I
|
V
|
L
|
S
|
H
|
T
|
279 |
N
|
S
|
V
|
V
|
N
|
P
|
F
|
I
|
Y
|
A
|
289 |
H8 | |||||||||
Y
|
R
|
I
|
R
|
E
|
F
|
R
|
Q
|
T
|
F
|
299 |
R
|
K
|
I
|
I
|
R
|
S
|
H
|
V
|
L
|
R
|
309 |
|
|||||||
Q
|
Q
|
E
|
P
|
F
|
K
|
A
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|