ednra_human
NAME
8HCQ
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
ednra_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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E
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T
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L
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C
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L
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R
|
A
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S
|
F
|
10 |
|
|
|
|
|
|
|
|
|
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W
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L
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A
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L
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V
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G
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C
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V
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I
|
S
|
20 |
D
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N
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P
|
E
|
R
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Y
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S
|
T
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N
|
L
|
30 |
S
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N
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H
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V
|
D
|
D
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F
|
T
|
T
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F
|
40 |
R
|
G
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T
|
E
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L
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S
|
F
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L
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V
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T
|
50 |
T
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H
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Q
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P
|
T
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N
|
L
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V
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L
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P
|
60 |
S
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N
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G
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S
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M
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H
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N
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Y
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C
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P
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70 |
TM1 | |||||||||
Q
|
Q
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T
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K
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I
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T
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S
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A
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F
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K
|
80 |
Y
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I
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N
|
T
|
V
|
I
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S
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C
|
T
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I
|
90 |
F
|
I
|
V
|
G
|
M
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V
|
G
|
N
|
A
|
T
|
100 |
L
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L
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R
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I
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I
|
Y
|
Q
|
N
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K
|
C
|
110 |
ICL1 | TM2 | ||||||||
M
|
R
|
N
|
G
|
P
|
N
|
A
|
L
|
I
|
A
|
120 |
S
|
L
|
A
|
L
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G
|
D
|
L
|
I
|
Y
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V
|
130 |
V
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I
|
D
|
L
|
P
|
I
|
N
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V
|
F
|
K
|
140 |
ECL1 | |||||||||
L
|
L
|
A
|
G
|
R
|
W
|
P
|
F
|
D
|
H
|
150 |
TM3 | |||||||||
N
|
D
|
F
|
G
|
V
|
F
|
L
|
C
|
K
|
L
|
160 |
F
|
P
|
F
|
L
|
Q
|
K
|
S
|
S
|
V
|
G
|
170 |
I
|
T
|
V
|
L
|
N
|
L
|
C
|
A
|
L
|
S
|
180 |
V
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D
|
R
|
Y
|
R
|
A
|
V
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A
|
S
|
W
|
190 |
ICL2 | TM4 | ||||||||
S
|
R
|
V
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Q
|
G
|
I
|
G
|
I
|
P
|
L
|
200 |
V
|
T
|
A
|
I
|
E
|
I
|
V
|
S
|
I
|
W
|
210 |
I
|
L
|
S
|
F
|
I
|
L
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A
|
I
|
P
|
E
|
220 |
ECL2 | |||||||||
A
|
I
|
G
|
F
|
V
|
M
|
V
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P
|
F
|
E
|
230 |
Y
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R
|
G
|
E
|
Q
|
H
|
K
|
T
|
C
|
M
|
240 |
TM5 | |||||||||
L
|
N
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A
|
T
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S
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K
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F
|
M
|
E
|
F
|
250 |
Y
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Q
|
D
|
V
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K
|
D
|
W
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W
|
L
|
F
|
260 |
G
|
F
|
Y
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F
|
C
|
M
|
P
|
L
|
V
|
C
|
270 |
T
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A
|
I
|
F
|
Y
|
T
|
L
|
M
|
T
|
C
|
280 |
E
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M
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L
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N
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R
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R
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N
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G
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S
|
L
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290 |
ICL3 | TM6 | ||||||||
R
|
I
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A
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L
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S
|
E
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H
|
L
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K
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Q
|
300 |
R
|
R
|
E
|
V
|
A
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K
|
T
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V
|
F
|
C
|
310 |
L
|
V
|
V
|
I
|
F
|
A
|
L
|
C
|
W
|
F
|
320 |
P
|
L
|
H
|
L
|
S
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R
|
I
|
L
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K
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K
|
330 |
ECL3 | |||||||||
T
|
V
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Y
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N
|
E
|
M
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D
|
K
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N
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R
|
340 |
TM7 | |||||||||
C
|
E
|
L
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L
|
S
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F
|
L
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L
|
L
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M
|
350 |
D
|
Y
|
I
|
G
|
I
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N
|
L
|
A
|
T
|
M
|
360 |
N
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S
|
C
|
I
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N
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P
|
I
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A
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L
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Y
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370 |
H8 | |||||||||
F
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V
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S
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K
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K
|
F
|
K
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N
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C
|
F
|
380 |
Q
|
S
|
C
|
L
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C
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C
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C
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C
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Y
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Q
|
390 |
C-term | |||||||||
S
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K
|
S
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L
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M
|
T
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S
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V
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P
|
M
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400 |
|
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|
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||||||
N
|
G
|
T
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S
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I
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Q
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W
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K
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N
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H
|
410 |
|
|
|
|
|
|
|
|
|
|
D
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Q
|
N
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N
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H
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N
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T
|
D
|
R
|
S
|
420 |
|
|
|
|
|
|
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S
|
H
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K
|
D
|
S
|
M
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N
|
|
|||||||||
N-term | |||||||||
|
S
|
D
|
N
|
P
|
E
|
R
|
Y
|
S
|
T
|
28 |
N
|
L
|
S
|
N
|
H
|
V
|
D
|
D
|
F
|
T
|
38 |
T
|
F
|
R
|
G
|
T
|
E
|
L
|
S
|
F
|
L
|
48 |
V
|
T
|
T
|
H
|
Q
|
P
|
T
|
N
|
L
|
V
|
58 |
L
|
P
|
S
|
N
|
G
|
S
|
M
|
H
|
N
|
Y
|
68 |
TM1 | |||||||||
C
|
P
|
Q
|
Q
|
T
|
K
|
I
|
T
|
S
|
A
|
78 |
F
|
K
|
Y
|
I
|
N
|
T
|
V
|
I
|
S
|
C
|
88 |
T
|
I
|
F
|
I
|
V
|
G
|
M
|
V
|
G
|
N
|
98 |
A
|
T
|
L
|
L
|
R
|
I
|
I
|
Y
|
Q
|
N
|
108 |
ICL1 | TM2 | ||||||||
K
|
C
|
M
|
R
|
N
|
G
|
P
|
N
|
A
|
L
|
118 |
I
|
A
|
S
|
L
|
A
|
L
|
G
|
D
|
L
|
I
|
128 |
Y
|
V
|
V
|
I
|
D
|
L
|
P
|
I
|
N
|
V
|
138 |
ECL1 | |||||||||
F
|
K
|
L
|
L
|
A
|
G
|
R
|
W
|
P
|
F
|
148 |
TM3 | |||||||||
D
|
H
|
N
|
D
|
F
|
G
|
V
|
F
|
L
|
C
|
158 |
K
|
L
|
F
|
P
|
F
|
L
|
Q
|
K
|
S
|
S
|
168 |
V
|
G
|
I
|
T
|
V
|
L
|
N
|
L
|
C
|
A
|
178 |
L
|
S
|
V
|
D
|
R
|
Y
|
R
|
A
|
V
|
A
|
188 |
ICL2 | |||||||||
S
|
W
|
S
|
R
|
V
|
Q
|
G
|
I
|
G
|
I
|
198 |
TM4 | |||||||||
P
|
L
|
V
|
T
|
A
|
I
|
E
|
I
|
V
|
S
|
208 |
I
|
W
|
I
|
L
|
S
|
F
|
I
|
L
|
A
|
I
|
218 |
ECL2 | |||||||||
P
|
E
|
A
|
I
|
G
|
F
|
V
|
M
|
V
|
P
|
228 |
F
|
E
|
Y
|
R
|
G
|
E
|
Q
|
H
|
K
|
T
|
238 |
TM5 | |||||||||
C
|
M
|
L
|
N
|
A
|
T
|
S
|
K
|
F
|
M
|
248 |
E
|
F
|
Y
|
Q
|
D
|
V
|
K
|
D
|
W
|
W
|
258 |
L
|
F
|
G
|
F
|
Y
|
F
|
C
|
M
|
P
|
L
|
268 |
V
|
C
|
T
|
A
|
I
|
F
|
Y
|
T
|
L
|
M
|
278 |
T
|
C
|
E
|
M
|
L
|
N
|
R
|
R
|
N
|
G
|
288 |
ICL3 | TM6 | ||||||||
S
|
L
|
R
|
I
|
A
|
L
|
S
|
E
|
H
|
L
|
298 |
K
|
Q
|
R
|
R
|
E
|
V
|
A
|
K
|
T
|
V
|
308 |
F
|
C
|
L
|
V
|
V
|
I
|
F
|
A
|
L
|
C
|
318 |
W
|
F
|
P
|
L
|
H
|
L
|
S
|
R
|
I
|
L
|
328 |
ECL3 | |||||||||
K
|
K
|
T
|
V
|
Y
|
N
|
E
|
M
|
D
|
K
|
338 |
TM7 | |||||||||
N
|
R
|
C
|
E
|
L
|
L
|
S
|
F
|
L
|
L
|
348 |
L
|
M
|
D
|
Y
|
I
|
G
|
I
|
N
|
L
|
A
|
358 |
T
|
M
|
N
|
S
|
C
|
I
|
N
|
P
|
I
|
A
|
368 |
H8 | |||||||||
L
|
Y
|
F
|
V
|
S
|
K
|
K
|
F
|
K
|
N
|
378 |
C
|
F
|
Q
|
S
|
C
|
L
|
C
|
C
|
C
|
C
|
388 |
C-term | |||||||||
Y
|
Q
|
S
|
K
|
S
|
L
|
M
|
T
|
S
|
V
|
398 |
|
||||||||
P
|
M
|
N
|
G
|
T
|
S
|
I
|
Q
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
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DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|