gp174_human
NAME
8KH5
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
gp174_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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|||||||||
N-term | |||||||||
M
|
P
|
A
|
N
|
Y
|
T
|
C
|
T
|
R
|
P
|
10 |
TM1 | |||||||||
D
|
G
|
D
|
N
|
T
|
D
|
F
|
R
|
Y
|
F
|
20 |
I
|
Y
|
A
|
V
|
T
|
Y
|
T
|
V
|
I
|
L
|
30 |
V
|
P
|
G
|
L
|
I
|
G
|
N
|
I
|
L
|
A
|
40 |
L
|
W
|
V
|
F
|
Y
|
G
|
Y
|
M
|
K
|
E
|
50 |
ICL1 | TM2 | ||||||||
T
|
K
|
R
|
A
|
V
|
I
|
F
|
M
|
I
|
N
|
60 |
L
|
A
|
I
|
A
|
D
|
L
|
L
|
Q
|
V
|
L
|
70 |
S
|
L
|
P
|
L
|
R
|
I
|
F
|
Y
|
Y
|
L
|
80 |
ECL1 | TM3 | ||||||||
N
|
H
|
D
|
W
|
P
|
F
|
G
|
P
|
G
|
L
|
90 |
C
|
M
|
F
|
C
|
F
|
Y
|
L
|
K
|
Y
|
V
|
100 |
N
|
M
|
Y
|
A
|
S
|
I
|
Y
|
F
|
L
|
V
|
110 |
C
|
I
|
S
|
V
|
R
|
R
|
F
|
W
|
F
|
L
|
120 |
ICL2 | |||||||||
M
|
Y
|
P
|
F
|
R
|
F
|
H
|
D
|
C
|
K
|
130 |
TM4 | |||||||||
Q
|
K
|
Y
|
D
|
L
|
Y
|
I
|
S
|
I
|
A
|
140 |
G
|
W
|
L
|
I
|
I
|
C
|
L
|
A
|
C
|
V
|
150 |
ECL2 | |||||||||
L
|
F
|
P
|
L
|
L
|
R
|
T
|
S
|
D
|
D
|
160 |
T
|
S
|
G
|
N
|
R
|
T
|
K
|
C
|
F
|
V
|
170 |
TM5 | |||||||||
D
|
L
|
P
|
T
|
R
|
N
|
V
|
N
|
L
|
A
|
180 |
Q
|
S
|
V
|
V
|
M
|
M
|
T
|
I
|
G
|
E
|
190 |
L
|
I
|
G
|
F
|
V
|
T
|
P
|
L
|
L
|
I
|
200 |
V
|
L
|
Y
|
C
|
T
|
W
|
K
|
T
|
V
|
L
|
210 |
ICL3 | |||||||||
S
|
L
|
Q
|
D
|
K
|
Y
|
P
|
M
|
A
|
Q
|
220 |
TM6 | |||||||||
D
|
L
|
G
|
E
|
K
|
Q
|
K
|
A
|
L
|
K
|
230 |
M
|
I
|
L
|
T
|
C
|
A
|
G
|
V
|
F
|
L
|
240 |
I
|
C
|
F
|
A
|
P
|
Y
|
H
|
F
|
S
|
F
|
250 |
P
|
L
|
D
|
F
|
L
|
V
|
K
|
S
|
N
|
E
|
260 |
ECL3 | TM7 | ||||||||
I
|
K
|
S
|
C
|
L
|
A
|
R
|
R
|
V
|
I
|
270 |
L
|
I
|
F
|
H
|
S
|
V
|
A
|
L
|
C
|
L
|
280 |
A
|
S
|
L
|
N
|
S
|
C
|
L
|
D
|
P
|
V
|
290 |
H8 | |||||||||
I
|
Y
|
Y
|
F
|
S
|
T
|
N
|
E
|
F
|
R
|
300 |
R
|
R
|
L
|
S
|
R
|
Q
|
D
|
L
|
H
|
D
|
310 |
C-term | |||||||||
S
|
I
|
Q
|
L
|
H
|
A
|
K
|
S
|
F
|
V
|
320 |
|
|
||||||||
S
|
N
|
H
|
T
|
A
|
S
|
T
|
M
|
T
|
P
|
330 |
|
|
|
E
|
L
|
C
|
|
|||||||||
N-term | |||||||||
|
P
|
A
|
N
|
Y
|
T
|
C
|
T
|
R
|
P
|
10 |
TM1 | |||||||||
D
|
G
|
D
|
N
|
T
|
D
|
F
|
R
|
Y
|
F
|
20 |
I
|
Y
|
A
|
V
|
T
|
Y
|
T
|
V
|
I
|
L
|
30 |
V
|
P
|
G
|
L
|
I
|
G
|
N
|
I
|
L
|
A
|
40 |
L
|
W
|
V
|
F
|
Y
|
G
|
Y
|
M
|
K
|
E
|
50 |
ICL1 | TM2 | ||||||||
T
|
K
|
R
|
A
|
V
|
I
|
F
|
M
|
I
|
N
|
60 |
L
|
A
|
I
|
A
|
D
|
L
|
L
|
Q
|
V
|
L
|
70 |
S
|
L
|
P
|
L
|
R
|
I
|
F
|
Y
|
Y
|
L
|
80 |
ECL1 | TM3 | ||||||||
N
|
H
|
D
|
W
|
P
|
F
|
G
|
P
|
G
|
L
|
90 |
C
|
M
|
F
|
C
|
F
|
Y
|
L
|
K
|
Y
|
V
|
100 |
N
|
M
|
Y
|
A
|
S
|
I
|
Y
|
F
|
L
|
V
|
110 |
C
|
I
|
S
|
V
|
R
|
R
|
F
|
W
|
F
|
L
|
120 |
ICL2 | |||||||||
M
|
Y
|
P
|
F
|
R
|
F
|
H
|
D
|
C
|
K
|
130 |
TM4 | |||||||||
Q
|
K
|
Y
|
D
|
L
|
Y
|
I
|
S
|
I
|
A
|
140 |
G
|
W
|
L
|
I
|
I
|
C
|
L
|
A
|
C
|
V
|
150 |
ECL2 | |||||||||
L
|
F
|
P
|
L
|
L
|
R
|
T
|
S
|
D
|
D
|
160 |
T
|
S
|
G
|
N
|
R
|
T
|
K
|
C
|
F
|
V
|
170 |
TM5 | |||||||||
D
|
L
|
P
|
T
|
R
|
N
|
V
|
N
|
L
|
A
|
180 |
Q
|
S
|
V
|
V
|
M
|
M
|
T
|
I
|
G
|
E
|
190 |
L
|
I
|
G
|
F
|
V
|
T
|
P
|
L
|
L
|
I
|
200 |
V
|
L
|
Y
|
C
|
T
|
W
|
K
|
T
|
V
|
L
|
210 |
ICL3 | |||||||||
S
|
L
|
Q
|
D
|
K
|
Y
|
P
|
M
|
A
|
Q
|
220 |
TM6 | |||||||||
D
|
L
|
G
|
E
|
K
|
Q
|
K
|
A
|
L
|
K
|
230 |
M
|
I
|
L
|
T
|
C
|
A
|
G
|
V
|
F
|
L
|
240 |
I
|
C
|
F
|
A
|
P
|
Y
|
H
|
F
|
S
|
F
|
250 |
P
|
L
|
D
|
F
|
L
|
V
|
K
|
S
|
N
|
E
|
260 |
ECL3 | TM7 | ||||||||
I
|
K
|
S
|
C
|
L
|
A
|
R
|
R
|
V
|
I
|
270 |
L
|
I
|
F
|
H
|
S
|
V
|
A
|
L
|
C
|
L
|
280 |
A
|
S
|
L
|
N
|
S
|
C
|
L
|
D
|
P
|
V
|
290 |
H8 | |||||||||
I
|
Y
|
Y
|
F
|
S
|
T
|
N
|
E
|
F
|
R
|
300 |
R
|
R
|
L
|
S
|
R
|
Q
|
D
|
L
|
H
|
D
|
310 |
C-term | |||||||||
S
|
I
|
Q
|
L
|
H
|
A
|
K
|
S
|
F
|
V
|
320 |
|
||||||||
S
|
N
|
H
|
T
|
A
|
S
|
T
|
M
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
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|
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|
|
|
|
|
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|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|