ada1a_human
NAME
8THK
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
ada1a_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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V
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F
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L
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S
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G
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N
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A
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S
|
D
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10 |
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|
|
||||||
S
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S
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N
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C
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T
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Q
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P
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P
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A
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P
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20 |
TM1 | |||||||||
V
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N
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I
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S
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K
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A
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I
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L
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L
|
G
|
30 |
V
|
I
|
L
|
G
|
G
|
L
|
I
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L
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F
|
G
|
40 |
V
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L
|
G
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N
|
I
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L
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V
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I
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L
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S
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50 |
ICL1 | |||||||||
V
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A
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C
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H
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R
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H
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L
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H
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S
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V
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60 |
TM2 | |||||||||
T
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H
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Y
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Y
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I
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V
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N
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L
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A
|
V
|
70 |
A
|
D
|
L
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L
|
L
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T
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S
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T
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V
|
L
|
80 |
P
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F
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S
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A
|
I
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F
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E
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V
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L
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G
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90 |
ECL1 | TM3 | ||||||||
Y
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W
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A
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F
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G
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R
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V
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F
|
C
|
N
|
100 |
I
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W
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A
|
A
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V
|
D
|
V
|
L
|
C
|
C
|
110 |
T
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A
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S
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I
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M
|
G
|
L
|
C
|
I
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I
|
120 |
S
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I
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D
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R
|
Y
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I
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G
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V
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S
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Y
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130 |
ICL2 | |||||||||
P
|
L
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R
|
Y
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P
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T
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I
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V
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T
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Q
|
140 |
TM4 | |||||||||
R
|
R
|
G
|
L
|
M
|
A
|
L
|
L
|
C
|
V
|
150 |
W
|
A
|
L
|
S
|
L
|
V
|
I
|
S
|
I
|
G
|
160 |
ECL2 | |||||||||
P
|
L
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F
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G
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W
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R
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Q
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P
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A
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P
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170 |
E
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D
|
E
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T
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I
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C
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Q
|
I
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N
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E
|
180 |
TM5 | |||||||||
E
|
P
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G
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Y
|
V
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L
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F
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S
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A
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L
|
190 |
G
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S
|
F
|
Y
|
L
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P
|
L
|
A
|
I
|
I
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200 |
L
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V
|
M
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Y
|
C
|
R
|
V
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Y
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V
|
V
|
210 |
A
|
K
|
R
|
E
|
S
|
R
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G
|
L
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K
|
S
|
220 |
|
|
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|||||||
ICL3 | |||||||||
G
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L
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K
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T
|
D
|
K
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S
|
D
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S
|
E
|
230 |
|
|
|
|
|
|
|
|
|
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Q
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V
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T
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L
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R
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I
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H
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R
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K
|
N
|
240 |
|
|
|
|
|
|
|
|
|
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A
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P
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A
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G
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G
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S
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G
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M
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A
|
S
|
250 |
|
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|
|
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|||||
A
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K
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T
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K
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T
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H
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F
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S
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V
|
R
|
260 |
TM6 | |||||||||
L
|
L
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K
|
F
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S
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R
|
E
|
K
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K
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A
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270 |
A
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K
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T
|
L
|
G
|
I
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V
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V
|
G
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C
|
280 |
F
|
V
|
L
|
C
|
W
|
L
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P
|
F
|
F
|
L
|
290 |
V
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M
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P
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I
|
G
|
S
|
F
|
F
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P
|
D
|
300 |
ECL3 | TM7 | ||||||||
F
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K
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P
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S
|
E
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T
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V
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F
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K
|
I
|
310 |
V
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F
|
W
|
L
|
G
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Y
|
L
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N
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S
|
C
|
320 |
I
|
N
|
P
|
I
|
I
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Y
|
P
|
C
|
S
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S
|
330 |
H8 | |||||||||
Q
|
E
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F
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K
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K
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A
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F
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Q
|
N
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V
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340 |
C-term | |||||||||
L
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R
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I
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Q
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C
|
L
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C
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R
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K
|
Q
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350 |
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|
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|
|
|
|
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S
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S
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K
|
H
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A
|
L
|
G
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Y
|
T
|
L
|
360 |
|
|
|
|
|
|
|
|
|
|
H
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P
|
P
|
S
|
Q
|
A
|
V
|
E
|
G
|
Q
|
370 |
|
|
|
|
|
|
|
|
|
|
H
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K
|
D
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M
|
V
|
R
|
I
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P
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V
|
G
|
380 |
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|
|
|
|
|
|
S
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R
|
E
|
T
|
F
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Y
|
R
|
I
|
S
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K
|
390 |
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|
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|
|
|
|
|
|
T
|
D
|
G
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V
|
C
|
E
|
W
|
K
|
F
|
F
|
400 |
|
|
|
|
|
|
|
|
|
|
S
|
S
|
M
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P
|
R
|
G
|
S
|
A
|
R
|
I
|
410 |
|
|
|
|
|
|
|
|
|
|
T
|
V
|
S
|
K
|
D
|
Q
|
S
|
S
|
C
|
T
|
420 |
|
|
|
|
|
|
|
|
|
|
T
|
A
|
R
|
V
|
R
|
S
|
K
|
S
|
F
|
L
|
430 |
|
|
|
|
|
|
|
|
|
|
Q
|
V
|
C
|
C
|
C
|
V
|
G
|
P
|
S
|
T
|
440 |
|
|
|
|
|
|
|
|
|
|
P
|
S
|
L
|
D
|
K
|
N
|
H
|
Q
|
V
|
P
|
450 |
|
|
|
|
|
|
|
|
|
|
T
|
I
|
K
|
V
|
H
|
T
|
I
|
S
|
L
|
S
|
460 |
|
|
|
|
|
|
E
|
N
|
G
|
E
|
E
|
V
|
|
|||||||||
N-term | TM1 | ||||||||
|
T
|
Q
|
P
|
P
|
A
|
P
|
V
|
N
|
I
|
23 |
S
|
K
|
A
|
I
|
L
|
L
|
G
|
V
|
I
|
L
|
33 |
G
|
G
|
L
|
I
|
L
|
F
|
G
|
V
|
L
|
G
|
43 |
N
|
I
|
L
|
V
|
I
|
L
|
S
|
V
|
A
|
C
|
53 |
ICL1 | TM2 | ||||||||
H
|
R
|
H
|
L
|
H
|
S
|
V
|
T
|
H
|
Y
|
63 |
Y
|
I
|
V
|
N
|
L
|
A
|
V
|
A
|
D
|
L
|
73 |
L
|
L
|
T
|
S
|
T
|
V
|
L
|
P
|
F
|
S
|
83 |
A
|
I
|
F
|
E
|
V
|
L
|
G
|
Y
|
W
|
A
|
93 |
ECL1 | TM3 | ||||||||
F
|
G
|
R
|
V
|
F
|
C
|
N
|
I
|
W
|
A
|
103 |
A
|
V
|
D
|
V
|
L
|
C
|
C
|
T
|
A
|
S
|
113 |
I
|
M
|
G
|
L
|
C
|
I
|
I
|
S
|
I
|
D
|
123 |
R
|
Y
|
I
|
G
|
V
|
S
|
Y
|
P
|
L
|
R
|
133 |
ICL2 | TM4 | ||||||||
Y
|
P
|
T
|
I
|
V
|
T
|
Q
|
R
|
R
|
G
|
143 |
L
|
M
|
A
|
L
|
L
|
C
|
V
|
W
|
A
|
L
|
153 |
S
|
L
|
V
|
I
|
S
|
I
|
G
|
P
|
L
|
F
|
163 |
ECL2 | |||||||||
G
|
W
|
R
|
Q
|
P
|
A
|
P
|
E
|
D
|
E
|
173 |
TM5 | |||||||||
T
|
I
|
C
|
Q
|
I
|
N
|
E
|
E
|
P
|
G
|
183 |
Y
|
V
|
L
|
F
|
S
|
A
|
L
|
G
|
S
|
F
|
193 |
Y
|
L
|
P
|
L
|
A
|
I
|
I
|
L
|
V
|
M
|
203 |
Y
|
C
|
R
|
V
|
Y
|
V
|
V
|
A
|
K
|
R
|
213 |
E
|
S
|
R
|
G
|
L
|
K
|
S
|
G
|
L
|
K
|
223 |
|
|||||||||
ICL3 | |||||||||
T
|
D
|
K
|
S
|
|
H
|
F
|
S
|
V
|
R
|
260 |
TM6 | |||||||||
L
|
L
|
K
|
F
|
S
|
R
|
E
|
K
|
K
|
A
|
270 |
A
|
K
|
T
|
L
|
G
|
I
|
V
|
V
|
G
|
C
|
280 |
F
|
V
|
L
|
C
|
W
|
L
|
P
|
F
|
F
|
L
|
290 |
V
|
M
|
P
|
I
|
G
|
S
|
F
|
F
|
P
|
D
|
300 |
ECL3 | TM7 | ||||||||
F
|
K
|
P
|
S
|
E
|
T
|
V
|
F
|
K
|
I
|
310 |
V
|
F
|
W
|
L
|
G
|
Y
|
L
|
N
|
S
|
C
|
320 |
I
|
N
|
P
|
I
|
I
|
Y
|
P
|
C
|
S
|
S
|
330 |
H8 | |||||||||
Q
|
E
|
F
|
K
|
K
|
A
|
F
|
Q
|
N
|
V
|
340 |
|
|||||||||||||||||||||
C-term | |||||||||||||||||||||
L
|
R
|
I
|
Q
|
C
|
L
|
C
|
R
|
K
|
Q
|
|
|||||||||||
350 |
SCHEMATIC
Perspective:
Wild-type
Construct
|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|