Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3UZA

SPECIES

Homo sapiens

RESOLUTION

3.270

PREFERRED CHAIN

A

REFERENCE

10.1021/jm201376w

PUBLICATION DATE

March 21, 2012

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
compound 4g [PMID: 22220592] F168 45.52x52 ECL2 aromatic (edge-to-face)
compound 4g [PMID: 22220592] M177 5.38x40 TM5 hydrophobic
compound 4g [PMID: 22220592] W246 6.48x48 TM6 hydrophobic
compound 4g [PMID: 22220592] L249 6.51x51 TM6 hydrophobic
compound 4g [PMID: 22220592] H250 6.52x52 TM6 aromatic (face-to-edge)
compound 4g [PMID: 22220592] N253 6.55x55 TM6 polar (hydrogen bond)
compound 4g [PMID: 22220592] N253 6.55x55 TM6 polar (hydrogen bond)
compound 4g [PMID: 22220592] I274 7.39x38 TM7 hydrophobic
compound 4g [PMID: 22220592] I274 7.39x38 TM7 Van der Waals
compound 4g [PMID: 22220592] H278 7.43x42 TM7 Van der Waals

Ligands

compound 4g [PMID: 22220592]

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x38 7.39x38 I274
7x42 7.43x42 H278