Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5EE7

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE17414

PUBLICATION DATE

April 20, 2016

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octaethylene glycol monoethyl ether Y145 1.43x43 TM1 hydrophobic
Octaethylene glycol monoethyl ether Y149 1.47x47 TM1 Van der Waals
Octaethylene glycol monoethyl ether Y149 1.47x47 TM1 polar (hydrogen bond)
Octaethylene glycol monoethyl ether F184 2.57x57 TM2 Van der Waals
Octaethylene glycol monoethyl ether K187 2.60x60 TM2 Van der Waals
Octaethylene glycol monoethyl ether V191 2.64x64 TM2 hydrophobic
Octaethylene glycol monoethyl ether V191 2.64x64 TM2 Van der Waals
Octaethylene glycol monoethyl ether I194 2.67x67 TM2 Van der Waals
Octaethylene glycol monoethyl ether I194 2.67x67 TM2 hydrophobic
Octaethylene glycol monoethyl ether R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Octaethylene glycol monoethyl ether I235 3.40x40 TM3 Van der Waals
Octaethylene glycol monoethyl ether I235 3.40x40 TM3 hydrophobic
Octaethylene glycol monoethyl ether N238 3.43x43 TM3 Van der Waals
Octaethylene glycol monoethyl ether Y239 3.44x44 TM3 Van der Waals
Octaethylene glycol monoethyl ether Y239 3.44x44 TM3 polar (hydrogen bond)
Octaethylene glycol monoethyl ether T296 45.52x52 ECL2 Van der Waals
Octaethylene glycol monoethyl ether M301 ECL2 Van der Waals
Octaethylene glycol monoethyl ether M301 ECL2 polar (hydrogen bond with backbone)
Octaethylene glycol monoethyl ether G302 ECL2 Van der Waals
Octaethylene glycol monoethyl ether F303 ECL2 hydrophobic
Octaethylene glycol monoethyl ether F303 ECL2 Van der Waals
Octaethylene glycol monoethyl ether H361 6.52x52 TM6 Van der Waals
Octaethylene glycol monoethyl ether H361 6.52x52 TM6 polar (hydrogen bond)
Octaethylene glycol monoethyl ether F362 6.53x53 TM6 Van der Waals
Octaethylene glycol monoethyl ether F362 6.53x53 TM6 hydrophobic
Octaethylene glycol monoethyl ether F365 6.56x56 TM6 hydrophobic
Octaethylene glycol monoethyl ether F365 6.56x56 TM6 Van der Waals
Octaethylene glycol monoethyl ether L386 7.43x42 TM7 hydrophobic
Octaethylene glycol monoethyl ether L386 7.43x42 TM7 Van der Waals
Octaethylene glycol monoethyl ether Q392 7.49x49 TM7 polar (hydrogen bond)
Octaethylene glycol monoethyl ether Q392 7.49x49 TM7 Van der Waals

Ligands

Octaethylene glycol monoethyl ether

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x50 2.57x57 F184
2x53 2.60x60 K187
2x57 2.64x64 V191
2x60 2.67x67 I194
2x65 2.72x72 R199
TM3
3x36 3.40x40 I235
3x39 3.43x43 N238
3x40 3.44x44 Y239
ECL2
45x52 45.52x52 T296
TM6
6x47 6.52x52 H361
6x48 6.53x53 E362
6x51 6.56x56 F365
TM7
7x38 7.43x42 L386
7x45 7.49x49 Q392