Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5OLH

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1038/S41598-017-18570-W

PUBLICATION DATE

Jan. 17, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
vipadenant Y9 1.35x35 TM1 polar (hydrogen bond)
vipadenant A63 2.61x60 TM2 Van der Waals
vipadenant A63 2.61x60 TM2 hydrophobic
vipadenant I66 2.64x63 TM2 Van der Waals
vipadenant I66 2.64x63 TM2 hydrophobic
vipadenant L85 3.33x33 TM3 Van der Waals
vipadenant F168 45.52x52 ECL2 aromatic (face-to-face)
vipadenant F168 45.52x52 ECL2 Van der Waals
vipadenant E169 ECL2 polar (charge-assisted hydrogen bond)
vipadenant M177 5.38x40 TM5 hydrophobic
vipadenant M177 5.38x40 TM5 Van der Waals
vipadenant W246 6.48x48 TM6 Van der Waals
vipadenant W246 6.48x48 TM6 hydrophobic
vipadenant L249 6.51x51 TM6 hydrophobic
vipadenant L249 6.51x51 TM6 Van der Waals
vipadenant H250 6.52x52 TM6 aromatic (face-to-edge)
vipadenant H250 6.52x52 TM6 Van der Waals
vipadenant N253 6.55x55 TM6 polar (hydrogen bond)
vipadenant N253 6.55x55 TM6 polar (hydrogen bond)
vipadenant M270 7.35x34 TM7 hydrophobic
vipadenant M270 7.35x34 TM7 Van der Waals
vipadenant Y271 7.36x35 TM7 hydrophobic
vipadenant Y271 7.36x35 TM7 Van der Waals
vipadenant I274 7.39x38 TM7 hydrophobic
vipadenant I274 7.39x38 TM7 Van der Waals

Ligands

vipadenant

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM1
1x35 1.35x35 Y9
TM2
2x60 2.61x60 A63
2x63 2.64x63 I66
TM3
3x33 3.33x33 L85
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274