Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5OLO

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

REFERENCE

10.1038/S41598-017-18570-W

PUBLICATION DATE

Jan. 17, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
tozadenant V84 3.32x32 TM3 hydrophobic
tozadenant F168 45.52x52 ECL2 aromatic (face-to-face)
tozadenant W246 6.48x48 TM6 hydrophobic
tozadenant L249 6.51x51 TM6 hydrophobic
tozadenant N253 6.55x55 TM6 polar (hydrogen bond)
tozadenant N253 6.55x55 TM6 polar (hydrogen bond)
tozadenant T256 6.58x58 TM6 polar (hydrogen bond)
tozadenant T256 6.58x58 TM6 Van der Waals
tozadenant H264 ECL3 Van der Waals
tozadenant H264 ECL3 polar (hydrogen bond)
tozadenant A265 ECL3 Van der Waals
tozadenant A265 ECL3 hydrophobic
tozadenant M270 7.35x34 TM7 hydrophobic
tozadenant M270 7.35x34 TM7 Van der Waals
tozadenant I274 7.39x38 TM7 hydrophobic
tozadenant I274 7.39x38 TM7 Van der Waals

Ligands

tozadenant

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x32 3.32x32 V84
ECL2
45x52 45.52x52 F168
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x55 6.55x55 N253
6x58 6.58x58 T256
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274