Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5VAI

SPECIES

Oryctolagus cuniculus

RESOLUTION

4.100

PREFERRED CHAIN

R

REFERENCE

10.1038/NATURE22394

PUBLICATION DATE

May 24, 2017

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL410972 L32 N-term polar (hydrogen bond with backbone)
CHEMBL410972 L32 N-term Van der Waals
CHEMBL410972 T35 N-term Van der Waals
CHEMBL410972 W39 N-term Van der Waals
CHEMBL410972 W39 N-term aromatic (face-to-edge)
CHEMBL410972 D68 N-term Van der Waals
CHEMBL410972 Y69 N-term Van der Waals
CHEMBL410972 Y69 N-term hydrophobic
CHEMBL410972 W91 N-term Van der Waals
CHEMBL410972 W91 N-term hydrophobic
CHEMBL410972 L118 N-term Van der Waals
CHEMBL410972 E128 N-term polar (charge-assisted hydrogen bond)
CHEMBL410972 E138 1.33x33 TM1 polar (charge-assisted hydrogen bond)
CHEMBL410972 E139 1.34x34 TM1 Van der Waals
CHEMBL410972 L142 1.37x37 TM1 Van der Waals
CHEMBL410972 L142 1.37x37 TM1 hydrophobic
CHEMBL410972 R190 2.60x60 TM2 Van der Waals
CHEMBL410972 V194 2.64x64 TM2 Van der Waals
CHEMBL410972 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
CHEMBL410972 L201 2.71x71 TM2 Van der Waals
CHEMBL410972 L201 2.71x71 TM2 hydrophobic
CHEMBL410972 M204 2.74x74 TM2 polar (hydrogen bond)
CHEMBL410972 Y205 2.75x75 TM2 hydrophobic
CHEMBL410972 Q211 2.81x81 TM2 Van der Waals
CHEMBL410972 H212 ECL1 aromatic (edge-to-face)
CHEMBL410972 H212 ECL1 Van der Waals
CHEMBL410972 M233 3.36x36 TM3 hydrophobic
CHEMBL410972 M233 3.36x36 TM3 Van der Waals
CHEMBL410972 Q234 3.37x37 TM3 Van der Waals
CHEMBL410972 V237 3.40x40 TM3 Van der Waals
CHEMBL410972 Y241 3.44x44 TM3 Van der Waals
CHEMBL410972 W297 45.51x51 ECL2 Van der Waals
CHEMBL410972 W297 45.51x51 ECL2 polar (hydrogen bond with backbone)
CHEMBL410972 T298 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL410972 T298 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL410972 R299 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL410972 R299 ECL2 polar (hydrogen bond with backbone)
CHEMBL410972 W306 5.36x37 TM5 polar (hydrogen bond)
CHEMBL410972 I309 5.39x39 TM5 hydrophobic
CHEMBL410972 I309 5.39x39 TM5 Van der Waals
CHEMBL410972 I313 5.43x43 TM5 hydrophobic
CHEMBL410972 F381 7.36x35 TM7 hydrophobic
CHEMBL410972 F385 7.40x39 TM7 Van der Waals
CHEMBL410972 F385 7.40x39 TM7 hydrophobic
CHEMBL410972 L388 7.43x42 TM7 Van der Waals
CHEMBL410972 L388 7.43x42 TM7 hydrophobic

Ligands

CHEMBL410972

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

V L A S F S L A Y G V T Y I I Y L S L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F K L Y L S G I W G V P L L F V I P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F 6 I A V M L G Q F S T F S L E T F L K V 7
Download: PNG | SVG
ICL1 R H L H ICL1ECL1 H Q W D G L L S Y Q D S ECL1ICL2 A V F ICL2ECL2 D E G C W T R N S ECL2ICL3 N L M C K T D I ICL3ECL3 V M D E H A R G T ECL3N-term M A G A P S P L R L A L L L L G A V G R A G P R P Q G A T V S L S E T V Q K W R E Y R R Q C Q H F L T E A P P L A T G L F C N R T F D D Y A C W P D G A P G S F V N V S C P W Y L P W A S N V L Q G H V Y R F C T T E G H W L H K D N S S L P W R D L S E C E E S R R G E K S S N-termC-term S M K P L K C P T S S L S S G A T G G S S V Y A A T S Q A C S C-term P E E Q L L S L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q L G C R L V F L L M Q Y C V A A N Y Y W L L V E G A Y L Y T L L A F S E Q R I F K L Y L S I G W G V P L L F V I P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F I R V I C I V V S K L K A K C R L A K S T L T L I P L L G T H E V I F A F L R F V K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L V Q R V Q M E S W E R E H L R D S
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x30 1.34x34 E139
1x33 1.37x37 L142
TM2
2x53 2.60x60 R190
2x57 2.64x64 V194
2x60 2.67x67 K197
2x64 2.71x71 L201
2x67 2.74x74 M204
2x68 2.75x75 Y205
2x74 2.81x81 Q211
TM3
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x51 45.51x51 W297
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x43 5.39x39 I309
5x47 5.43x43 I313
TM7
7x31 7.36x35 F381
7x35 7.40x39 F385
7x38 7.43x42 L388