Structure information

PAF receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5ZKP

SPECIES

Homo sapiens

RESOLUTION

2.810

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-018-0068-Y

PUBLICATION DATE

June 20, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
foropafant Y22 1.39x39 TM1 hydrophobic
foropafant W73 2.60x60 TM2 aromatic (face-to-face)
foropafant Y77 2.64x64 TM2 polar (hydrogen bond)
foropafant Y77 2.64x64 TM2 Van der Waals
foropafant G94 3.29x29 TM3 Van der Waals
foropafant F97 3.32x32 TM3 Van der Waals
foropafant F97 3.32x32 TM3 aromatic (face-to-edge)
foropafant F98 3.33x33 TM3 Van der Waals
foropafant F98 3.33x33 TM3 aromatic (edge-to-face)
foropafant T101 3.36x36 TM3 Van der Waals
foropafant Y102 3.37x37 TM3 hydrophobic
foropafant Y102 3.37x37 TM3 Van der Waals
foropafant F174 45.51x51 ECL2 hydrophobic
foropafant F174 45.51x51 ECL2 Van der Waals
foropafant Y177 ECL2 Van der Waals
foropafant I191 5.43x43 TM5 hydrophobic
foropafant I191 5.43x43 TM5 Van der Waals
foropafant W255 6.58x58 TM6 hydrophobic
foropafant W255 6.58x58 TM6 Van der Waals
foropafant H275 7.35x34 TM7 Van der Waals
foropafant L279 7.39x38 TM7 hydrophobic
foropafant L279 7.39x38 TM7 Van der Waals

Ligands

foropafant

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Residue Diagrams

G N A I V G L V F I I S Y V I P F L T Y 1 V N L T M A D M L F L I T L P L W I V Y 2 V G L F A V S C Y T N I F F L C G A V N 3 G I S L S L V I W V A I V G A A S Y F L 4 N C F L I I L F V L F F S F V I F I H I 5 V C T V L A V F I I C F V P H H V V Q L P 6 V P D L V C N T S L L C L T V Q H A D 7
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ICL1 P C K K ICL1ECL1 G N W I L ECL1ICL2 P I K T A Q A N ICL2ECL2 D S T N T V P D S A G S G N V T R C F E H Y E K G ECL2ICL3 P V Q Q ICL3ECL3 F Q ECL3N-term M E P H D S S H M N-termC-term S R K C S R A T T D T V T E V V V P F N Q I P G N S L K N C-term D S E F R Y T L F P I V Y S I I F V L G V I A N G Y V L W V F A R L Y F N E I K I F M V N L T M A D M L F L I T L P L W I V Y Y Q N Q P K F L C N V A G C L F F I N T Y C S V A F L G V I T Y N R F Q A V T R T R K R G I S L S L V I W V A I V G A A S Y F L I L S V P V L I I H I F I V F S F F L V F L I I L F C N L V I I R T L L M Q Q R N A E V K R R A L W M V C T V L A V F I I C F V P H H V V Q L P W T L A E L G D S K F H Q A I N D A H Q V T L C L L S T N C V L D P V I Y C F L T K K F R K K F Y H L T E S M R S
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Residue Table


GPCRdb(A)
GPCRdb(A)
PAF receptor
TM1
1x39 1.39x39 Y22
TM2
2x60 2.60x60 W73
2x64 2.64x64 Y77
TM3
3x29 3.29x29 G94
3x32 3.32x32 F97
3x33 3.33x33 F98
3x36 3.36x36 T101
3x37 3.37x37 Y102
ECL2
45x51 45.51x51 F174
TM5
5x43 5.43x43 I191
TM6
6x58 6.58x58 W255
TM7
7x34 7.35x34 H275
7x38 7.39x38 L279