Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6A94

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-018-0180-Z

PUBLICATION DATE

Feb. 13, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
zotepine W151 3.28x28 TM3 hydrophobic
zotepine D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
zotepine V156 3.33x33 TM3 hydrophobic
zotepine V156 3.33x33 TM3 Van der Waals
zotepine S159 3.36x36 TM3 Van der Waals
zotepine L229 45.52x52 ECL2 Van der Waals
zotepine L229 45.52x52 ECL2 hydrophobic
zotepine V235 5.39x40 TM5 hydrophobic
zotepine V235 5.39x40 TM5 Van der Waals
zotepine G238 5.42x43 TM5 Van der Waals
zotepine S239 5.43x44 TM5 Van der Waals
zotepine S242 5.46x461 TM5 Van der Waals
zotepine F332 6.44x44 TM6 hydrophobic
zotepine F332 6.44x44 TM6 Van der Waals
zotepine W336 6.48x48 TM6 aromatic (face-to-edge)
zotepine W336 6.48x48 TM6 Van der Waals
zotepine F339 6.51x51 TM6 hydrophobic
zotepine F339 6.51x51 TM6 Van der Waals
zotepine F340 6.52x52 TM6 Van der Waals
zotepine F340 6.52x52 TM6 aromatic (edge-to-face)
zotepine V366 7.39x38 TM7 Van der Waals

Ligands

zotepine

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
ECL2
45x52 45.52x52 L229
TM5
5x40 5.39x40 V235
5x43 5.42x43 G238
5x44 5.43x44 S239
5x461 5.46x461 S242
TM6
6x44 6.44x44 F332
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366