Structure information

CCR2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6GPS

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

10.1016/J.STR.2018.10.027

PUBLICATION DATE

Jan. 2, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MK-0812 V37 1.27x27 TM1 polar (hydrogen bond with backbone)
MK-0812 V37 1.27x27 TM1 polar (hydrogen bond)
MK-0812 I40 1.30x30 TM1 polar (hydrogen bond)
MK-0812 G41 1.31x31 TM1 polar (hydrogen bond)
MK-0812 G41 1.31x31 TM1 polar (hydrogen bond with backbone)
MK-0812 L44 1.34x34 TM1 polar (hydrogen bond)
MK-0812 L45 1.35x35 TM1 polar (hydrogen bond)
MK-0812 Y49 1.39x39 TM1 polar (hydrogen bond)
MK-0812 Y49 1.39x39 TM1 polar (hydrogen bond)
MK-0812 W98 2.60x60 TM2 Van der Waals
MK-0812 W98 2.60x60 TM2 polar (hydrogen bond with backbone)
MK-0812 S101 2.63x63 TM2 Van der Waals
MK-0812 A102 2.64x64 TM2 Van der Waals
MK-0812 A102 2.64x64 TM2 polar (hydrogen bond with backbone)
MK-0812 T117 3.29x29 TM3 polar (hydrogen bond)
MK-0812 Y120 3.32x32 TM3 hydrophobic
MK-0812 Y120 3.32x32 TM3 Van der Waals
MK-0812 H121 3.33x33 TM3 polar (hydrogen bond)
MK-0812 T179 4.64x65 TM4 Van der Waals
MK-0812 C190 45.50x50 ECL2 polar (hydrogen bond with backbone)
MK-0812 C190 45.50x50 ECL2 polar (hydrogen bond)
MK-0812 G191 45.51x51 ECL2 Van der Waals
MK-0812 Q288 7.36x35 TM7 polar (hydrogen bond)
MK-0812 Q288 7.36x35 TM7 polar (hydrogen bond with backbone)
MK-0812 V289 7.37x36 TM7 polar (hydrogen bond)
MK-0812 E291 7.39x38 TM7 polar (charge-charge)
MK-0812 E291 7.39x38 TM7 polar (charge-assisted hydrogen bond)
MK-0812 T292 7.40x39 TM7 polar (hydrogen bond)
MK-0812 M295 7.43x42 TM7 polar (hydrogen bond)

Ligands

MK-0812

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L Q A 1 L N L A I S D L L F L I T L P L W A H S 2 L I I F F I G G F Y G I H Y L G T F L K 3 G V V T S V I T W L V A V F A S V P G 4 Y C I V M I L L P L V L G L I N R M I T H 5 F T I M I V Y F L F W T P Y N I V I L L 6 I P N I C C H T M G L T E T V Q T A Q 7
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ICL1 K K L K ICL1ECL1 E W V F ECL1ICL2 A V F A L K A R ICL2ECL2 K C Q K E D S V Y V C G P Y F ECL2ICL3 R ICL3ECL3 L S N C ECL3N-term M L S T S R S R F I R N T N E S G E E V T T F F D Y D Y G A P C H K F D N-termC-term G C R I A P L Q K P V C G G P G V R P G K N V K V T T Q G L L D G R G K G K S I G R A P E A S L Q D K E G A C-term V K Q I G A Q L L P P L Y S L V F I F G F V G N M L V V L I L I N C C L T D I Y L L N L A I S D L L F L I T L P L W A H S A A N G N A M C K L F T G L Y H I G Y F G G I F F I I L L T I D R Y L A I V H T V T F G V V T S V I T W L V A V F A S V P G I I F T P R G W N N F H T I M R N I L G L V L P L L I M V I C Y S G I L K T L L R C N E K K R H R A V R V I F T I M I V Y F L F W T P Y N I V I L L N T F Q E F F G E S T S Q L D Q A T Q V T E T L G M T H C C I N P I I Y A F V G E K F H I F R S L A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR2
TM1
1x27 1.27x27 V37
1x30 1.30x30 I40
1x31 1.31x31 G41
1x34 1.34x34 L44
1x35 1.35x35 L45
1x39 1.39x39 Y49
TM2
2x60 2.60x60 W98
2x63 2.63x63 S101
2x64 2.64x64 A102
TM3
3x29 3.29x29 T117
3x32 3.32x32 Y120
3x33 3.33x33 H121
TM4
4x65 4.64x65 T179
ECL2
45x50 45.50x50 C190
45x51 45.51x51 G191
TM7
7x35 7.36x35 Q288
7x36 7.37x36 V289
7x38 7.39x38 E291
7x39 7.40x39 T292
7x42 7.43x42 M295