Structure information

CXCR2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6LFM

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-020-2492-5

PUBLICATION DATE

Sept. 2, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Interleukin-8 S27 N-term Van der Waals
Interleukin-8 T28 N-term Van der Waals
Interleukin-8 L29 N-term hydrophobic
Interleukin-8 L29 N-term Van der Waals
Interleukin-8 F32 N-term Van der Waals
Interleukin-8 F32 N-term hydrophobic
Interleukin-8 L34 N-term hydrophobic
Interleukin-8 A36 N-term Van der Waals
Interleukin-8 A37 N-term Van der Waals
Interleukin-8 A37 N-term hydrophobic
Interleukin-8 P38 N-term Van der Waals
Interleukin-8 P38 N-term hydrophobic
Interleukin-8 E40 N-term polar (charge-assisted hydrogen bond)
Interleukin-8 V187 ECL2 Van der Waals
Interleukin-8 V187 ECL2 hydrophobic
Interleukin-8 S189 ECL2 Van der Waals
Interleukin-8 N191 ECL2 Van der Waals
Interleukin-8 N191 ECL2 polar (hydrogen bond)
Interleukin-8 V192 ECL2 Van der Waals
Interleukin-8 V192 ECL2 hydrophobic
Interleukin-8 Y197 45.51x51 ECL2 polar (hydrogen bond)
Interleukin-8 Y197 45.51x51 ECL2 Van der Waals
Interleukin-8 Y197 45.51x51 ECL2 polar (hydrogen bond)
Interleukin-8 G201 ECL2 Van der Waals
Interleukin-8 G201 ECL2 polar (hydrogen bond with backbone)
Interleukin-8 N202 ECL2 Van der Waals
Interleukin-8 T204 5.31x32 TM5 Van der Waals
Interleukin-8 R208 5.35x36 TM5 polar (charge-assisted hydrogen bond)
Interleukin-8 T285 7.24x23 TM7 Van der Waals
Interleukin-8 C286 7.25x24 TM7 Van der Waals
Interleukin-8 R289 7.28x27 TM7 polar (charge-assisted hydrogen bond)
Interleukin-8 D293 7.32x31 TM7 Van der Waals
Interleukin-8 L296 7.35x34 TM7 hydrophobic
Interleukin-8 L296 7.35x34 TM7 Van der Waals
Interleukin-8 E300 7.39x38 TM7 Van der Waals

Ligands

Interleukin-8

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Residue Diagrams

S N G L L S L L F V L A Y I I V V F Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F I C L S I W G L S L L L A L P V 4 Y C F L M I L L P V I F G F S Q P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 L P N L C S H L I G L I E T A D L A R 7
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ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R Y ICL2ECL2 R T V Y S S N V S P A C Y E D M G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M E D F N M E S D S F E D F W K G E D L S N Y S Y S S T L P P F L L D A A P C E P E S L N-termC-term G L I S K D S L P K D S R P S F V G S S S G H T S T T L C-term E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F I C L S I W G L S L L L A L P V L L F R N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K L L K H F R H G I L A I
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Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR2
ECL2
45x51 45.51x51 Y197
TM5
5x32 5.31x32 T204
5x36 5.35x36 R208
TM7
7x23 7.24x23 T285
7x24 7.25x24 C286
7x27 7.28x27 R289
7x31 7.32x31 D293
7x34 7.35x34 L296
7x38 7.39x38 E300