Structure information

FPR2/ALX

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6LW5

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-020-15009-1

PUBLICATION DATE

March 25, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL552527 F5 N-term hydrophobic
CHEMBL552527 P8 N-term hydrophobic
CHEMBL552527 E89 ECL1 polar (charge-assisted hydrogen bond)
CHEMBL552527 H102 3.29x29 TM3 Van der Waals
CHEMBL552527 V105 3.32x32 TM3 Van der Waals
CHEMBL552527 D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
CHEMBL552527 L109 3.36x36 TM3 Van der Waals
CHEMBL552527 L109 3.36x36 TM3 hydrophobic
CHEMBL552527 F110 3.37x37 TM3 Van der Waals
CHEMBL552527 F110 3.37x37 TM3 hydrophobic
CHEMBL552527 L164 4.64x65 TM4 hydrophobic
CHEMBL552527 T177 45.51x51 ECL2 Van der Waals
CHEMBL552527 F178 45.52x52 ECL2 aromatic (face-to-edge)
CHEMBL552527 F178 45.52x52 ECL2 Van der Waals
CHEMBL552527 F180 ECL2 Van der Waals
CHEMBL552527 F180 ECL2 aromatic (edge-to-face)
CHEMBL552527 L198 5.35x36 TM5 hydrophobic
CHEMBL552527 L198 5.35x36 TM5 Van der Waals
CHEMBL552527 R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
CHEMBL552527 R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
CHEMBL552527 W254 6.48x48 TM6 Van der Waals
CHEMBL552527 F257 6.51x51 TM6 hydrophobic
CHEMBL552527 F257 6.51x51 TM6 Van der Waals
CHEMBL552527 A261 6.55x55 TM6 Van der Waals
CHEMBL552527 M271 ECL3 hydrophobic
CHEMBL552527 M271 ECL3 Van der Waals
CHEMBL552527 D281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CHEMBL552527 D281 7.32x31 TM7 polar (hydrogen bond with backbone)
CHEMBL552527 V284 7.35x34 TM7 hydrophobic
CHEMBL552527 V284 7.35x34 TM7 Van der Waals
CHEMBL552527 N285 7.36x35 TM7 polar (hydrogen bond)
CHEMBL552527 F292 7.43x42 TM7 hydrophobic
CHEMBL552527 F292 7.43x42 TM7 Van der Waals

Ligands

CHEMBL552527

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Residue Diagrams

G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7
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ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM3
3x29 3.29x29 H102
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
TM4
4x65 4.64x65 L164
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x55 6.55x55 A261
TM7
7x31 7.32x31 D281
7x34 7.35x34 V284
7x35 7.36x35 N285
7x42 7.43x42 F292