Structure information

MT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6ME3

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-019-1141-3

PUBLICATION DATE

April 24, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL15060 M107 3.32x32 TM3 hydrophobic
CHEMBL15060 V111 3.36x36 TM3 hydrophobic
CHEMBL15060 N162 4.60x61 TM4 polar (hydrogen bond)
CHEMBL15060 N162 4.60x61 TM4 Van der Waals
CHEMBL15060 L168 ECL2 Van der Waals
CHEMBL15060 T178 45.51x51 ECL2 Van der Waals
CHEMBL15060 F179 45.52x52 ECL2 hydrophobic
CHEMBL15060 F179 45.52x52 ECL2 Van der Waals
CHEMBL15060 Q181 ECL2 polar (hydrogen bond)
CHEMBL15060 Q181 ECL2 Van der Waals
CHEMBL15060 V191 5.42x43 TM5 Van der Waals
CHEMBL15060 V191 5.42x43 TM5 hydrophobic
CHEMBL15060 L254 6.51x51 TM6 hydrophobic
CHEMBL15060 L254 6.51x51 TM6 Van der Waals
CHEMBL15060 N255 6.52x52 TM6 Van der Waals
CHEMBL15060 Y281 7.39x38 TM7 Van der Waals
CHEMBL15060 Y281 7.39x38 TM7 hydrophobic
CHEMBL15060 A284 7.42x41 TM7 Van der Waals
CHEMBL15060 Y285 7.43x42 TM7 Van der Waals
CHEMBL15060 Y285 7.43x42 TM7 hydrophobic

Ligands

CHEMBL15060

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Residue Diagrams

L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7
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ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x32 3.32x32 M107
3x36 3.36x36 V111
TM4
4x61 4.60x61 N162
ECL2
45x51 45.51x51 T178
45x52 45.52x52 F179
TM5
5x43 5.42x43 V191
TM6
6x51 6.51x51 L254
6x52 6.52x52 N255
TM7
7x38 7.39x38 Y281
7x41 7.42x41 A284
7x42 7.43x42 Y285