Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6MET

SPECIES

Homo sapiens

RESOLUTION

4.500

PREFERRED CHAIN

B

REFERENCE

10.1038/S41586-018-0804-9

PUBLICATION DATE

Dec. 12, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Envelope glycoprotein gp160 M1 N-term Van der Waals
Envelope glycoprotein gp160 M1 N-term hydrophobic
Envelope glycoprotein gp160 D2 N-term polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 D2 N-term Van der Waals
Envelope glycoprotein gp160 Y3 N-term Van der Waals
Envelope glycoprotein gp160 Y3 N-term hydrophobic
Envelope glycoprotein gp160 V5 N-term hydrophobic
Envelope glycoprotein gp160 V5 N-term Van der Waals
Envelope glycoprotein gp160 D11 N-term polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 D11 N-term polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 N13 N-term Van der Waals
Envelope glycoprotein gp160 Y15 N-term polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 Y15 N-term Van der Waals
Envelope glycoprotein gp160 Y15 N-term polar (hydrogen bond)
Envelope glycoprotein gp160 V25 N-term Van der Waals
Envelope glycoprotein gp160 K26 1.28x28 TM1 Van der Waals
Envelope glycoprotein gp160 A29 1.31x31 TM1 Van der Waals
Envelope glycoprotein gp160 W86 2.60x60 TM2 Van der Waals
Envelope glycoprotein gp160 W86 2.60x60 TM2 hydrophobic
Envelope glycoprotein gp160 Y89 2.63x63 TM2 Van der Waals
Envelope glycoprotein gp160 F109 3.33x33 TM3 Van der Waals
Envelope glycoprotein gp160 F109 3.33x33 TM3 hydrophobic
Envelope glycoprotein gp160 E172 ECL2 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 G173 ECL2 Van der Waals
Envelope glycoprotein gp160 T177 ECL2 polar (hydrogen bond)
Envelope glycoprotein gp160 C178 45.50x50 ECL2 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 C178 45.50x50 ECL2 Van der Waals
Envelope glycoprotein gp160 S179 45.51x51 ECL2 polar (hydrogen bond)
Envelope glycoprotein gp160 S180 45.52x52 ECL2 Van der Waals
Envelope glycoprotein gp160 S180 45.52x52 ECL2 polar (hydrogen bond with backbone)
Envelope glycoprotein gp160 H181 ECL2 Van der Waals
Envelope glycoprotein gp160 F182 ECL2 hydrophobic
Envelope glycoprotein gp160 F182 ECL2 Van der Waals
Envelope glycoprotein gp160 Y187 5.31x32 TM5 hydrophobic
Envelope glycoprotein gp160 Y187 5.31x32 TM5 Van der Waals
Envelope glycoprotein gp160 K191 5.35x36 TM5 Van der Waals
Envelope glycoprotein gp160 Q194 5.38x39 TM5 Van der Waals
Envelope glycoprotein gp160 Y251 6.51x51 TM6 polar (hydrogen bond)
Envelope glycoprotein gp160 L255 6.55x55 TM6 Van der Waals
Envelope glycoprotein gp160 N258 6.58x58 TM6 polar (hydrogen bond)
Envelope glycoprotein gp160 D276 7.32x31 TM7 polar (charge-assisted hydrogen bond)
Envelope glycoprotein gp160 M279 7.35x34 TM7 polar (hydrogen bond)
Envelope glycoprotein gp160 Q280 7.36x35 TM7 Van der Waals
Envelope glycoprotein gp160 E283 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

Envelope glycoprotein gp160

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM1
1x28 1.28x28 K26
1x31 1.31x31 A29
TM2
2x60 2.60x60 W86
2x63 2.63x63 Y89
TM3
3x33 3.33x33 F109
ECL2
45x50 45.50x50 C178
45x51 45.51x51 S179
45x52 45.52x52 S180
TM5
5x32 5.31x32 Y187
5x36 5.35x36 K191
5x39 5.38x39 Q194
TM6
6x51 6.51x51 Y251
6x55 6.55x55 L255
6x58 6.58x58 N258
TM7
7x31 7.32x31 D276
7x34 7.35x34 M279
7x35 7.36x35 Q280
7x38 7.39x38 E283