Structure information

CRF2 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6PB1

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

P

REFERENCE

10.1016/J.MOLCEL.2020.01.013

PUBLICATION DATE

Feb. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Urocortin Q106 N-term polar (hydrogen bond)
Urocortin Q106 N-term polar (hydrogen bond)
Urocortin R107 N-term polar (charge-assisted hydrogen bond)
Urocortin Y113 1.36x36 TM1 hydrophobic
Urocortin Y113 1.36x36 TM1 Van der Waals
Urocortin L117 1.40x40 TM1 Van der Waals
Urocortin L117 1.40x40 TM1 hydrophobic
Urocortin W166 2.64x64 TM2 polar (hydrogen bond)
Urocortin W166 2.64x64 TM2 Van der Waals
Urocortin L169 2.67x67 TM2 Van der Waals
Urocortin L169 2.67x67 TM2 hydrophobic
Urocortin V172 ECL1 Van der Waals
Urocortin D173 ECL1 Van der Waals
Urocortin H174 ECL1 Van der Waals
Urocortin H177 ECL1 Van der Waals
Urocortin E178 ECL1 polar (charge-assisted hydrogen bond)
Urocortin F191 3.36x36 TM3 hydrophobic
Urocortin F191 3.36x36 TM3 Van der Waals
Urocortin N192 3.37x37 TM3 Van der Waals
Urocortin F199 3.44x44 TM3 hydrophobic
Urocortin F199 3.44x44 TM3 Van der Waals
Urocortin F256 45.52x52 ECL2 Van der Waals
Urocortin F256 45.52x52 ECL2 polar (hydrogen bond with backbone)
Urocortin K258 ECL2 Van der Waals
Urocortin Q269 5.40x40 TM5 Van der Waals
Urocortin Q269 5.40x40 TM5 polar (hydrogen bond)
Urocortin I272 5.43x43 TM5 hydrophobic
Urocortin I272 5.43x43 TM5 Van der Waals
Urocortin Y323 6.53x53 TM6 Van der Waals
Urocortin Y323 6.53x53 TM6 hydrophobic
Urocortin F326 ECL3 Van der Waals
Urocortin F327 ECL3 Van der Waals
Urocortin F327 ECL3 hydrophobic
Urocortin F340 7.38x37 TM7 Van der Waals
Urocortin F340 7.38x37 TM7 hydrophobic
Urocortin I341 7.39x38 TM7 hydrophobic
Urocortin N344 7.42x41 TM7 polar (hydrogen bond)
Urocortin Q348 7.46x45 TM7 Van der Waals

Ligands

Urocortin

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Residue Diagrams

V L A A V S V C H G L Y N V V L A I R Y 1 W N L I T T F I L R N V M W F L L Q L V 2 V F M W F F N T V V F Y N F I T T I C R 3 R K C L F L F G I W C I P F P I I V A W A 4 L F V F N I L L V L I I P G Q Y I Y D V 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S Q L F S N F Y I F M 7
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ICL1 R S I R ICL1ECL1 D H E V H E S N ECL1ICL2 T Y S T E R L ICL2ECL2 N E Q C W F G K E P G D L ECL2ICL3 S T T ICL3ECL3 N P G E D ECL3N-term M D A A L L H S L L E A N C S L A L A E E L L L D G W G P P L D P E G P Y S Y C N T T L D Q I G T C W P R S A A G A L V E R P C P E Y F N G V K Y N T T R N A Y R E C L E N G T W A S K I N Y S Q C E N-termC-term R A M S I P T S P T R I S F H S I K Q T A A V C-term P I L D D K Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L C L R N V I H W N L I T T F I L R N V M W F L L Q L V E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R K W Q D R V P V R S A R W H R H H S L M A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF2 receptor
TM1
1x32 1.36x36 Y113
1x36 1.40x40 L117
TM2
2x57 2.64x64 W166
2x60 2.67x67 L169
TM3
3x32 3.36x36 F191
3x33 3.37x37 N192
3x40 3.44x44 F199
ECL2
45x52 45.52x52 F256
TM5
5x44 5.40x40 Q269
5x47 5.43x43 I272
TM6
6x48 6.53x53 Y323
TM7
7x33 7.38x37 F340
7x34 7.39x38 I341
7x37 7.42x41 N344
7x41 7.46x45 Q348