Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6UP7

SPECIES

Homo sapiens

RESOLUTION

4.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-020-1953-1

PUBLICATION DATE

Feb. 26, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
JMV431 L54 N-term polar (hydrogen bond with backbone)
JMV431 L54 N-term Van der Waals
JMV431 F127 2.65x64 TM2 hydrophobic
JMV431 F127 2.65x64 TM2 Van der Waals
JMV431 H131 ECL1 Van der Waals
JMV431 Y145 3.29x29 TM3 polar (hydrogen bond)
JMV431 Y145 3.29x29 TM3 Van der Waals
JMV431 T225 45.51x51 ECL2 Van der Waals
JMV431 F326 6.58x58 TM6 hydrophobic
JMV431 F326 6.58x58 TM6 Van der Waals
JMV431 I329 ECL3 hydrophobic
JMV431 W334 ECL3 Van der Waals
JMV431 Y342 7.31x30 TM7 Van der Waals
JMV431 Y342 7.31x30 TM7 polar (hydrogen bond)
JMV431 Y346 7.35x34 TM7 hydrophobic

Ligands

JMV431

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Residue Diagrams

T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
ECL2
45x51 45.51x51 T225
TM6
6x58 6.58x58 F326
TM7
7x30 7.31x30 Y342
7x34 7.35x34 Y346