Structure information

calcitonin receptor-like receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6UUN

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1021/ACSPTSCI.9B00080

PUBLICATION DATE

March 25, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Adrenomedullin V36 N-term hydrophobic
Adrenomedullin F92 N-term hydrophobic
Adrenomedullin Q93 N-term polar (hydrogen bond with backbone)
Adrenomedullin Q93 N-term Van der Waals
Adrenomedullin D94 N-term Van der Waals
Adrenomedullin P97 N-term Van der Waals
Adrenomedullin H114 N-term Van der Waals
Adrenomedullin R119 N-term Van der Waals
Adrenomedullin T120 N-term polar (hydrogen bond with backbone)
Adrenomedullin T120 N-term Van der Waals
Adrenomedullin W121 N-term hydrophobic
Adrenomedullin W121 N-term Van der Waals
Adrenomedullin T122 N-term Van der Waals
Adrenomedullin K134 1.32x32 TM1 Van der Waals
Adrenomedullin V135 1.33x33 TM1 hydrophobic
Adrenomedullin V135 1.33x33 TM1 Van der Waals
Adrenomedullin A138 1.36x36 TM1 Van der Waals
Adrenomedullin L195 2.68x68 TM2 Van der Waals
Adrenomedullin L195 2.68x68 TM2 hydrophobic
Adrenomedullin A199 ECL1 hydrophobic
Adrenomedullin A199 ECL1 Van der Waals
Adrenomedullin N200 ECL1 Van der Waals
Adrenomedullin Q202 ECL1 Van der Waals
Adrenomedullin Q202 ECL1 polar (hydrogen bond)
Adrenomedullin H219 3.36x36 TM3 Van der Waals
Adrenomedullin L220 3.37x37 TM3 Van der Waals
Adrenomedullin M223 3.40x40 TM3 Van der Waals
Adrenomedullin M223 3.40x40 TM3 hydrophobic
Adrenomedullin Y227 3.44x44 TM3 Van der Waals
Adrenomedullin I284 45.52x52 ECL2 Van der Waals
Adrenomedullin I284 45.52x52 ECL2 hydrophobic
Adrenomedullin S285 ECL2 Van der Waals
Adrenomedullin S286 ECL2 Van der Waals
Adrenomedullin S286 ECL2 polar (hydrogen bond with backbone)
Adrenomedullin H289 ECL2 polar (hydrogen bond)
Adrenomedullin L291 5.36x37 TM5 Van der Waals
Adrenomedullin Y292 5.37x38 TM5 polar (hydrogen bond)
Adrenomedullin Y292 5.37x38 TM5 polar (hydrogen bond)
Adrenomedullin H295 5.40x40 TM5 Van der Waals
Adrenomedullin H295 5.40x40 TM5 polar (hydrogen bond)
Adrenomedullin C299 5.44x44 TM5 Van der Waals
Adrenomedullin F349 6.53x53 TM6 Van der Waals
Adrenomedullin F349 6.53x53 TM6 hydrophobic
Adrenomedullin H370 7.43x42 TM7 Van der Waals
Adrenomedullin M373 7.46x45 TM7 polar (hydrogen bond)

Ligands

Adrenomedullin

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Residue Diagrams

L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L H 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7
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ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 N D N C W I S S D ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L Y F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
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Residue Table


GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM1
1x28 1.32x32 K134
1x29 1.33x33 V135
1x32 1.36x36 A138
TM2
2x61 2.68x68 L195
TM3
3x32 3.36x36 H219
3x33 3.37x37 L220
3x36 3.40x40 M223
3x40 3.44x44 Y227
ECL2
45x52 45.52x52 I284
TM5
5x41 5.36x37 L291
5x42 5.37x38 Y292
5x44 5.40x40 H295
5x48 5.44x44 C299
TM6
6x48 6.53x53 F349
TM7
7x38 7.43x42 H370
7x41 7.46x45 M373