Structure information

M1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6WJC

SPECIES

Homo sapiens

RESOLUTION

2.550

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.AAX2517

PUBLICATION DATE

July 8, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
muscarinic toxin 7 Y85 2.64x63 TM2 hydrophobic
HYOSCYAMINE Y106 3.33x33 TM3 hydrophobic
muscarinic toxin 7 W164 4.64x64 TM4 Van der Waals
muscarinic toxin 7 W164 4.64x64 TM4 polar (hydrogen bond)
muscarinic toxin 7 V168 4.68x68 TM4 hydrophobic
muscarinic toxin 7 V168 4.68x68 TM4 Van der Waals
muscarinic toxin 7 E170 ECL2 polar (charge-assisted hydrogen bond)
muscarinic toxin 7 T172 ECL2 Van der Waals
muscarinic toxin 7 T172 ECL2 polar (hydrogen bond with backbone)
muscarinic toxin 7 L174 ECL2 Van der Waals
muscarinic toxin 7 L174 ECL2 hydrophobic
muscarinic toxin 7 Q177 ECL2 Van der Waals
muscarinic toxin 7 C178 45.50x50 ECL2 Van der Waals
muscarinic toxin 7 Y179 45.51x51 ECL2 Van der Waals
muscarinic toxin 7 Y179 45.51x51 ECL2 hydrophobic
muscarinic toxin 7 Q181 ECL2 Van der Waals
muscarinic toxin 7 F182 ECL2 hydrophobic
muscarinic toxin 7 F182 ECL2 Van der Waals
muscarinic toxin 7 L183 ECL2 Van der Waals
muscarinic toxin 7 S184 ECL2 Van der Waals
muscarinic toxin 7 Q185 5.35x36 TM5 Van der Waals
muscarinic toxin 7 P186 5.36x37 TM5 hydrophobic
muscarinic toxin 7 P186 5.36x37 TM5 Van der Waals
HYOSCYAMINE A196 5.46x461 TM5 hydrophobic
HYOSCYAMINE W378 6.48x48 TM6 hydrophobic
HYOSCYAMINE Y381 6.51x51 TM6 hydrophobic
HYOSCYAMINE N382 6.52x52 TM6 Van der Waals
HYOSCYAMINE N382 6.52x52 TM6 polar (hydrogen bond)
muscarinic toxin 7 E397 7.32x31 TM7 polar (charge-assisted hydrogen bond)
muscarinic toxin 7 W400 7.35x34 TM7 hydrophobic
muscarinic toxin 7 W400 7.35x34 TM7 Van der Waals
muscarinic toxin 7 E401 7.36x35 TM7 polar (charge-assisted hydrogen bond)
muscarinic toxin 7 Y404 7.39x38 TM7 Van der Waals
HYOSCYAMINE Y404 7.39x38 TM7 hydrophobic
HYOSCYAMINE Y404 7.39x38 TM7 Van der Waals
HYOSCYAMINE C407 7.42x41 TM7 Van der Waals
HYOSCYAMINE Y408 7.43x42 TM7 hydrophobic
HYOSCYAMINE Y408 7.43x42 TM7 Van der Waals

Ligands

muscarinic toxin 7

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HYOSCYAMINE

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Residue Diagrams

L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7
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ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term G P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M1 receptor
TM2
2x63 2.64x63 Y85
TM3
3x33 3.33x33 Y106
TM4
4x64 4.64x64 W164
4x68 4.68x68 V168
ECL2
45x50 45.50x50 C178
45x51 45.51x51 Y179
TM5
5x36 5.35x36 Q185
5x37 5.36x37 P186
5x461 5.46x461 A196
TM6
6x48 6.48x48 W378
6x51 6.51x51 Y381
6x52 6.52x52 N382
TM7
7x31 7.32x31 E397
7x34 7.35x34 W400
7x35 7.36x35 E401
7x38 7.39x38 Y404
7x41 7.42x41 C407
7x42 7.43x42 Y408