Structure information

SMO

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

6XBJ

SPECIES

Homo sapiens

RESOLUTION

3.880

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-020-0646-2

PUBLICATION DATE

Sept. 30, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol W281 2.58x58 TM2 hydrophobic
Cholesterol L325 3.36x36 TM3 hydrophobic
Cholesterol V329 3.40x40 TM3 hydrophobic
Cholesterol F332 3.43x43 TM3 hydrophobic
Cholesterol Y394 ECL2 polar (hydrogen bond)
Cholesterol Y394 ECL2 Van der Waals
Cholesterol V404 5.47x47 TM5 hydrophobic
Cholesterol V404 5.47x47 TM5 Van der Waals
Cholesterol I408 5.51x51 TM5 Van der Waals
Cholesterol I408 5.51x51 TM5 hydrophobic
Cholesterol V463 6.44x44 TM6 hydrophobic
Cholesterol V463 6.44x44 TM6 Van der Waals
Cholesterol T466 6.47x47 TM6 Van der Waals
Cholesterol H470 6.51x51 TM6 Van der Waals
Cholesterol N521 7.41x41 TM7 Van der Waals
Cholesterol M525 7.45x45 TM7 Van der Waals
Cholesterol M525 7.45x45 TM7 hydrophobic
Cholesterol T528 7.48x48 TM7 Van der Waals

Ligands

Cholesterol

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Residue Diagrams

L T C L G T V A G F A A I Y S H M D Q H 1 F Y V N A C F F V G S I G W L A Q F 2 V V F W V V G A M L A Y Y V I V F I I V 3 T S Y F H L L T W S L P F V L T V A I L 4 L F Y G G V I L V L G I P A L V F G A R Y 5 G I F G F L A F G F V L I T F S C H F Y 6 T S M A I G T G F M A F L N I K E V L L 7
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ICL1 W R N S N ICL1ECL1 M D G A R R E I V C R A D G T M R L G E P T S N E T ECL1ICL2 L G T T Y Q P L S G ICL2ECL2 Q V D G D S V S G I C F V G Y K ECL2ICL3 P G L L ICL3ECL3 G L P T K Q P I P D C E I K N R P ECL3N-term M A A A R P A R G P E L P L L G L L L L L L L G D P G R G A A S S G N A T G P G P R S A G G S A R R S A A V T G P P P P L S H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F N-termC-term G Q S D D E P K R I K K S K M I A K A F S K R H E L L Q N P G Q E L S F S M H T V S H D G P V A G L A F D L N E P S A D V S S A W A Q H V T K M V A R R G A I L P Q D I S V T P V A T P V P P E E Q A N L W L V E A E I S P E L Q K R L G R K K K R R K R K K E V C P L A P P P E L H P P A P A P S T I P R L P Q L P R Q K C L V A A G A W G A G D S C R Q G A W T L V S N P F C P E P S P P Q D P F L P S A P A P V A W A H G R R Q G L G P I H S R T N L M D T E L M D A D S D F C-term T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D R Y P A V I L F Y V N A C F F V G S I G W L A Q F L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A K T S Y F H L L T W S L P F V L T V A I L A V A N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I S L L V E K I N L F A M F G T G I A M S T W V W T K A W R R L T T L L I T W C R
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Residue Table


GPCRdb(A)
GPCRdb(F)
SMO
TM2
2x57 2.58x58 W281
TM3
3x36 3.36x36 L325
3x40 3.40x40 V329
3x43 3.43x43 F332
TM5
5x43 5.47x47 V404
5x47 5.51x51 I408
TM6
6x48 6.44x44 V463
6x51 6.47x47 T466
6x55 6.51x51 H470
TM7
7x38 7.41x41 N521
7x42 7.45x45 M525
7x45 7.48x48 T528