Structure information

GHRH receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7CZ5

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-020-18945-0

PUBLICATION DATE

Nov. 18, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Somatoliberin L119 1.29x29 TM1 hydrophobic
Somatoliberin F126 1.36x36 TM1 hydrophobic
Somatoliberin V129 1.39x39 TM1 hydrophobic
Somatoliberin Y133 1.43x43 TM1 aromatic (edge-to-face)
Somatoliberin K182 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Somatoliberin F187 2.72x72 TM2 aromatic (face-to-edge)
Somatoliberin F187 2.72x72 TM2 Van der Waals
Somatoliberin D193 ECL1 polar (hydrogen bond with backbone)
Somatoliberin D193 ECL1 Van der Waals
Somatoliberin H194 ECL1 polar (hydrogen bond with backbone)
Somatoliberin H194 ECL1 polar (hydrogen bond)
Somatoliberin C195 ECL1 Van der Waals
Somatoliberin C195 ECL1 polar (hydrogen bond)
Somatoliberin H210 3.37x37 TM3 polar (hydrogen bond)
Somatoliberin H210 3.37x37 TM3 Van der Waals
Somatoliberin T213 3.40x40 TM3 Van der Waals
Somatoliberin A271 ECL2 polar (hydrogen bond with backbone)
Somatoliberin A271 ECL2 Van der Waals
Somatoliberin D274 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Somatoliberin D274 45.52x52 ECL2 polar (hydrogen bond with backbone)
Somatoliberin D276 ECL2 polar (charge-assisted hydrogen bond)
Somatoliberin W282 5.36x37 TM5 hydrophobic
Somatoliberin W282 5.36x37 TM5 Van der Waals
Somatoliberin I289 5.43x43 TM5 Van der Waals
Somatoliberin I289 5.43x43 TM5 hydrophobic
Somatoliberin N346 ECL3 polar (hydrogen bond)
Somatoliberin D350 ECL3 Van der Waals
Somatoliberin L354 7.35x34 TM7 hydrophobic
Somatoliberin L354 7.35x34 TM7 Van der Waals
Somatoliberin R357 7.38x37 TM7 Van der Waals
Somatoliberin L358 7.39x38 TM7 Van der Waals
Somatoliberin E361 7.42x41 TM7 Van der Waals
Somatoliberin L362 7.43x42 TM7 Van der Waals
Somatoliberin L362 7.43x42 TM7 hydrophobic

Ligands

Somatoliberin

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Residue Diagrams

F L A V I S I S H G V T Y I I K V T S F 1 T Q L F T T F I L K A G A V F L K D A A 2 A L L W S F N T M T A F H S A A V S V K 3 A F W W L V L G A W G L P V L F T G T W V 4 F L G F N V G V S L V I P G K I I W W 5 L F L I P L F G I H Y I I F N F L 6 I A V I F G Q F S G L G L E L P L R I 7
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ICL1 R R L H ICL1ECL1 H S D D T D H C S F S ECL1ICL2 T S P S S ICL2ECL2 D I A C W D L D D T S P Y ECL2ICL3 E P A Q G S L ICL3ECL3 P D N A ECL3N-term M D R R M W G A H V F C V L S P L P T V L G H M H P E C D F I T Q L R E D E S A C L Q A A E E M P N T T L G C P A T W D G L L C W P T A G S G E W V T L P C P D F F S H F S S E S G A V K R D C T I T G W S E P F P P Y P V A C P V P N-termC-term A K W T T P S R S A A K V L T S M C C-term L E L L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L H T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E I S R H D P A W R V R T E K W H G E L L P T R
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Residue Table


GPCRdb(A)
GPCRdb(B)
GHRH receptor
TM1
1x25 1.29x29 L119
1x32 1.36x36 F126
1x35 1.39x39 V129
1x39 1.43x43 Y133
TM2
2x60 2.67x67 K182
2x65 2.72x72 F187
TM3
3x33 3.37x37 H210
3x36 3.40x40 T213
ECL2
45x52 45.52x52 D274
TM5
5x41 5.36x37 W282
5x47 5.43x43 I289
TM7
7x30 7.35x34 L354
7x33 7.38x37 R357
7x34 7.39x38 L358
7x37 7.42x41 E361
7x38 7.43x42 L362