Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7E14

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-24058-Z

PUBLICATION DATE

July 7, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
orforglipron W33 N-term hydrophobic
orforglipron P137 N-term hydrophobic
orforglipron L141 1.36x36 TM1 hydrophobic
orforglipron L144 1.39x39 TM1 hydrophobic
orforglipron Y145 1.40x40 TM1 aromatic (face-to-edge)
orforglipron Y148 1.43x43 TM1 hydrophobic
orforglipron D198 2.68x68 TM2 polar (charge-assisted hydrogen bond)
orforglipron A200 2.70x70 TM2 Van der Waals
orforglipron A200 2.70x70 TM2 hydrophobic
orforglipron L201 2.71x71 TM2 Van der Waals
orforglipron L201 2.71x71 TM2 hydrophobic
orforglipron K202 2.72x72 TM2 Van der Waals
orforglipron M204 2.74x74 TM2 Van der Waals
orforglipron Y205 2.75x75 TM2 aromatic (face-to-edge)
orforglipron Y205 2.75x75 TM2 Van der Waals
orforglipron Y220 ECL1 Van der Waals
orforglipron Y220 ECL1 polar (hydrogen bond)
orforglipron C226 3.29x29 TM3 polar (hydrogen bond)
orforglipron C226 3.29x29 TM3 Van der Waals
orforglipron V229 3.32x32 TM3 hydrophobic
orforglipron V229 3.32x32 TM3 Van der Waals
orforglipron F230 3.33x33 TM3 Van der Waals
orforglipron F230 3.33x33 TM3 hydrophobic
orforglipron M233 3.36x36 TM3 Van der Waals
orforglipron M233 3.36x36 TM3 hydrophobic
orforglipron T298 45.52x52 ECL2 Van der Waals
orforglipron L384 7.39x38 TM7 hydrophobic
orforglipron L384 7.39x38 TM7 Van der Waals
orforglipron L388 7.43x42 TM7 Van der Waals
orforglipron L388 7.43x42 TM7 hydrophobic

Ligands

orforglipron

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x61 2.68x68 D198
2x63 2.70x70 A200
2x64 2.71x71 L201
2x65 2.72x72 K202
2x67 2.74x74 M204
2x68 2.75x75 Y205
TM3
3x25 3.29x29 C226
3x28 3.32x32 V229
3x29 3.33x33 F230
3x32 3.36x36 M233
ECL2
45x52 45.52x52 T298
TM7
7x34 7.39x38 L384
7x38 7.43x42 L388