Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EO2

SPECIES

Homo sapiens

RESOLUTION

2.890

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-021-00930-3

PUBLICATION DATE

Jan. 5, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(S)-FTY720-phosphate Y29 N-term polar (hydrogen bond)
(S)-FTY720-phosphate K34 N-term polar (charge-assisted hydrogen bond)
(S)-FTY720-phosphate N101 2.60x60 TM2 polar (hydrogen bond)
(S)-FTY720-phosphate S105 2.64x64 TM2 Van der Waals
(S)-FTY720-phosphate T109 23.50x50 ECL1 polar (hydrogen bond)
(S)-FTY720-phosphate E121 3.29x29 TM3 Van der Waals
(S)-FTY720-phosphate M124 3.32x32 TM3 hydrophobic
(S)-FTY720-phosphate M124 3.32x32 TM3 Van der Waals
(S)-FTY720-phosphate F125 3.33x33 TM3 Van der Waals
(S)-FTY720-phosphate F125 3.33x33 TM3 hydrophobic
(S)-FTY720-phosphate L128 3.36x36 TM3 hydrophobic
(S)-FTY720-phosphate L128 3.36x36 TM3 Van der Waals
(S)-FTY720-phosphate F210 5.47x47 TM5 Van der Waals
(S)-FTY720-phosphate F210 5.47x47 TM5 hydrophobic
(S)-FTY720-phosphate L272 6.51x51 TM6 Van der Waals

Ligands

(S)-FTY720-phosphate

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
2x64 2.64x64 S105
ECL1
23x50 23.50x50 T109
TM3
3x29 3.29x29 E121
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
TM5
5x47 5.47x47 F210
TM6
6x51 6.51x51 L272