Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7L0S

SPECIES

Rattus norvegicus

RESOLUTION

4.500

PREFERRED CHAIN

C

REFERENCE

10.1038/S41594-020-00554-6

PUBLICATION DATE

Jan. 6, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
neurotensin D54 N-term polar (charge-assisted hydrogen bond)
neurotensin L55 N-term Van der Waals
neurotensin L55 N-term hydrophobic
neurotensin F128 2.65x64 TM2 Van der Waals
neurotensin H132 ECL1 polar (hydrogen bond with backbone)
neurotensin H132 ECL1 Van der Waals
neurotensin H133 ECL1 Van der Waals
neurotensin Y146 3.29x29 TM3 polar (hydrogen bond)
neurotensin M208 4.64x65 TM4 Van der Waals
neurotensin M208 4.64x65 TM4 hydrophobic
neurotensin V224 ECL2 hydrophobic
neurotensin V224 ECL2 Van der Waals
neurotensin T226 45.51x51 ECL2 Van der Waals
neurotensin I238 5.39x40 TM5 Van der Waals
neurotensin R327 6.54x54 TM6 Van der Waals
neurotensin R328 6.55x55 TM6 Van der Waals
neurotensin F331 6.58x58 TM6 polar (hydrogen bond with backbone)
neurotensin F331 6.58x58 TM6 Van der Waals
neurotensin I334 6.61x61 TM6 Van der Waals
neurotensin I334 6.61x61 TM6 polar (hydrogen bond with backbone)
neurotensin S335 ECL3 Van der Waals
neurotensin D336 ECL3 polar (charge-assisted hydrogen bond)
neurotensin W339 ECL3 polar (hydrogen bond)
neurotensin F344 7.28x27 TM7 Van der Waals
neurotensin F344 7.28x27 TM7 hydrophobic
neurotensin Y347 7.31x30 TM7 polar (hydrogen bond)
neurotensin Y347 7.31x30 TM7 Van der Waals
neurotensin H348 7.32x31 TM7 Van der Waals
neurotensin Y351 7.35x34 TM7 hydrophobic
neurotensin Y351 7.35x34 TM7 Van der Waals

Ligands

neurotensin

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Residue Diagrams

S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F128
TM3
3x29 3.29x29 Y146
TM4
4x65 4.64x65 M208
ECL2
45x51 45.51x51 T226
TM5
5x40 5.39x40 I238
TM6
6x54 6.54x54 R327
6x55 6.55x55 R328
6x58 6.58x58 F331
6x61 6.61x61 I334
TM7
7x27 7.28x27 F344
7x30 7.31x30 Y347
7x31 7.32x31 H348
7x34 7.35x34 Y351