Structure information

OX2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7L1U

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-21087-6

PUBLICATION DATE

Feb. 10, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Orexin-A W120 23.50x50 ECL1 hydrophobic
Orexin-A Q134 3.32x32 TM3 polar (hydrogen bond)
Orexin-A Q134 3.32x32 TM3 Van der Waals
Orexin-A V138 3.36x36 TM3 Van der Waals
Orexin-A V138 3.36x36 TM3 hydrophobic
Orexin-A V209 ECL2 Van der Waals
Orexin-A V209 ECL2 hydrophobic
Orexin-A C210 45.50x50 ECL2 Van der Waals
Orexin-A D211 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
Orexin-A F227 5.42x43 TM5 hydrophobic
Orexin-A N324 6.55x55 TM6 Van der Waals
Orexin-A N324 6.55x55 TM6 polar (hydrogen bond)
Orexin-A K327 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Orexin-A F333 ECL3 polar (hydrogen bond with backbone)
Orexin-A F333 ECL3 Van der Waals
Orexin-A A334 ECL3 Van der Waals
Orexin-A T336 ECL3 polar (hydrogen bond with backbone)
Orexin-A T336 ECL3 Van der Waals
Orexin-A R339 7.28x27 TM7 polar (charge-assisted hydrogen bond)
Orexin-A Y343 7.32x31 TM7 hydrophobic
Orexin-A Y343 7.32x31 TM7 Van der Waals
Orexin-A F346 7.35x34 TM7 hydrophobic
Orexin-A F346 7.35x34 TM7 Van der Waals
Orexin-A H350 7.39x38 TM7 polar (hydrogen bond)
Orexin-A H350 7.39x38 TM7 Van der Waals
Orexin-A Y354 7.43x42 TM7 Van der Waals

Ligands

Orexin-A

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Residue Diagrams

V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7
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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX2 receptor
ECL1
23x50 23.50x50 W120
TM3
3x32 3.32x32 Q134
3x36 3.36x36 V138
ECL2
45x50 45.50x50 C210
45x51 45.51x51 D211
TM5
5x43 5.42x43 F227
TM6
6x55 6.55x55 N324
6x58 6.58x58 K327
TM7
7x27 7.28x27 R339
7x31 7.32x31 Y343
7x34 7.35x34 F346
7x38 7.39x38 H350
7x42 7.43x42 Y354