Structure information

CaS receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

7M3G

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-021-03691-0

PUBLICATION DATE

June 30, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
evocalcet Q681 3.33x33 TM3 polar (hydrogen bond)
evocalcet Q681 3.33x33 TM3 polar (hydrogen bond)
evocalcet F684 3.36x36 TM3 aromatic (edge-to-face)
evocalcet F684 3.36x36 TM3 Van der Waals
evocalcet G685 3.37x37 TM3 Van der Waals
evocalcet L773 5.40x40 TM5 hydrophobic
evocalcet I777 5.44x44 TM5 hydrophobic
evocalcet I777 5.44x44 TM5 Van der Waals
evocalcet T780 5.47x47 TM5 Van der Waals
evocalcet C781 5.48x48 TM5 Van der Waals
evocalcet W818 6.50x50 TM6 Van der Waals
evocalcet W818 6.50x50 TM6 polar (hydrogen bond with backbone)
evocalcet I822 6.54x54 TM6 Van der Waals
evocalcet I822 6.54x54 TM6 hydrophobic
evocalcet Y825 6.57x57 TM6 hydrophobic
evocalcet Y825 6.57x57 TM6 Van der Waals
evocalcet E837 7.32x33 TM7 Van der Waals

Ligands

evocalcet

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Residue Diagrams

A T L F I G L V A F L T L A I G F P E 1 Y L L L F S L L C C F S S S L F F I 2 V L I C S I C L V F S I G F A P Q R L R 3 Q F L L V F L C T F M Q I V I C V I W L 4 A F F F C I A A L L C T Y G I L F G L A 5 T F S M L I F F I V W I S F I P A Y A S 6 A L L G F S A A L I A I V E V A S V F K 7
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ICL1 T R N P I V K A T ICL1ECL1 G E P ECL1ICL2 E A K I P T S F H R K W W ICL2ECL2 P P S S Y R N Q E L E D E I I F I T C H E G S ECL2ICL3 P E N F ICL3ECL3 Y ECL3N-term M A F Y S C C W V L L A L T W H T S A Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q E G A K G P L P V D T F L R G H E E S G D R F S N S S T A F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T N-termC-term T A A H A F K V A A R A T L R R S N V S R K R S S S L G G S T G S T P S S S I S S K S N S E D P F P Q P E R Q K Q Q Q P L A L T Q Q E Q Q Q Q P L T L P Q Q Q R S Q Q Q P R C K Q K V I F G S G T V T F S L S F D E P Q K N A M A H R N S T H Q N S L E A Q K S S D T L T R H E P L L P L Q C G E T D L D L T V Q E T G L Q G P V G G D Q R P E V E D P E E L S P A L V V S S S Q S F V I S G G G S T V T E N V V N S C-term E P F G I A L T L F A V L G I F L T A F V L G V F I K F N R E L S Y L L L F S L L C C F S S S L F F I Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A L M A L G F L I G Y T C L L A A I C F F F A F K S R K L N E A K F I T F S M L I F F I V W I S F I P A Y A S T G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S R E V R N T I E C S
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Residue Table


GPCRdb(A)
GPCRdb(C)
CaS receptor
TM3
3x29 3.33x33 Q681
3x32 3.36x36 F684
3x33 3.37x37 G685
TM5
5x40 5.40x40 L773
5x44 5.44x44 I777
5x47 5.47x47 T780
5x48 5.48x48 C781
TM6
6x48 6.50x50 W818
6x52 6.54x54 I822
6x55 6.57x57 Y825
TM7
7x38 7.32x33 E837