Structure information

NK1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7RMG

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-021-00890-8

PUBLICATION DATE

Nov. 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
substance P Q24 N-term polar (hydrogen bond)
substance P Q24 N-term Van der Waals
substance P F25 N-term Van der Waals
substance P F25 N-term aromatic (face-to-edge)
substance P N85 2.57x57 TM2 polar (hydrogen bond)
substance P N85 2.57x57 TM2 Van der Waals
substance P N85 2.57x57 TM2 polar (hydrogen bond)
substance P N89 2.61x61 TM2 polar (hydrogen bond)
substance P N89 2.61x61 TM2 polar (hydrogen bond)
substance P N89 2.61x61 TM2 polar (hydrogen bond)
substance P Y92 2.64x64 TM2 Van der Waals
substance P Y92 2.64x64 TM2 hydrophobic
substance P N96 ECL1 polar (hydrogen bond)
substance P N96 ECL1 Van der Waals
substance P H108 3.28x28 TM3 Van der Waals
substance P N109 3.29x29 TM3 Van der Waals
substance P I113 3.33x33 TM3 hydrophobic
substance P I113 3.33x33 TM3 Van der Waals
substance P Q165 4.60x61 TM4 Van der Waals
substance P E172 ECL2 Van der Waals
substance P M174 ECL2 hydrophobic
substance P M174 ECL2 Van der Waals
substance P R177 ECL2 polar (charge-assisted hydrogen bond)
substance P V179 ECL2 hydrophobic
substance P V179 ECL2 Van der Waals
substance P C180 45.50x50 ECL2 Van der Waals
substance P M181 45.51x51 ECL2 hydrophobic
substance P M181 45.51x51 ECL2 Van der Waals
substance P F264 6.51x51 TM6 Van der Waals
substance P F264 6.51x51 TM6 hydrophobic
substance P F268 6.55x55 TM6 hydrophobic
substance P F268 6.55x55 TM6 Van der Waals
substance P Y278 ECL3 Van der Waals
substance P Y278 ECL3 polar (hydrogen bond with backbone)
substance P Q284 7.32x31 TM7 Van der Waals
substance P Y287 7.35x34 TM7 aromatic (face-to-edge)
substance P Y287 7.35x34 TM7 polar (hydrogen bond)
substance P Y287 7.35x34 TM7 polar (hydrogen bond)
substance P Y287 7.35x34 TM7 Van der Waals

Ligands

substance P

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Residue Diagrams

V N G V V S T V V I V T Y A A A W L V I 1 V N L A F A E A S M A A F N T V V N F T 2 A T M S Y I S A F V A A I P F F N H F K 3 T K V V I C V I W V L A L L L A F P Q 4 Y A Y G I V L L P L F Y I L V T V C I H Y 5 I V V V C T F A I C W L P F H I F F L L 6 I P N Y M T S S M A L W M I A L Y V Q 7
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ICL1 K R M R ICL1ECL1 E W Y Y ECL1ICL2 P L Q P R L ICL2ECL2 T T E T M P S R V V C M I E W P E H ECL2ICL3 S S D ICL3ECL3 P D L Y L K ECL3N-term M D N V L P V D S D L S P N I S T N T S E P N Q F V Q N-termC-term R C C P F I S A G D Y E G L E M K S T R Y L Q T Q G S V Y K V S R L E T T I S T V V G A H E E E P E D G P K A T P S S L D L T S N C S S R S D S K T M T E S F S F S S N V L S C-term P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W A S E I P G D R Y H E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F K H F R L G A F
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Residue Table


GPCRdb(A)
GPCRdb(A)
NK1 receptor
TM2
2x57 2.57x57 N85
2x61 2.61x61 N89
2x64 2.64x64 Y92
TM3
3x28 3.28x28 H108
3x29 3.29x29 N109
3x33 3.33x33 I113
TM4
4x61 4.60x61 Q165
ECL2
45x50 45.50x50 C180
45x51 45.51x51 M181
TM6
6x51 6.51x51 F264
6x55 6.55x55 F268
TM7
7x31 7.32x31 Q284
7x34 7.35x34 Y287